Antitumor activities of dFv-LDP-AE: An enediyne-energized fusion protein targeting tumor-associated antigen gelatinases.

abstract：:All-trans retinoic acid (ATRA) is a potent chemopreventive and therapeutic agent and exerts its effects by inducing growth arrest. In the present study, we demonstrated that ATRA activated the expression of p53 via Axin and induced cell cycle arrest at the G1/S phase and apoptosis of glioma cells. Briefly, C6 cells we...

journal_title：Oncology reports

authors： Lu J,Zhang F,Yuan Y,Ding C,Zhang L,Li Q

更新日期：2013-06-01 00:00:00

abstract：:TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...

journal_title：Oncology reports

authors： Qiu X,Huang Y,Zhou Y,Zheng F

更新日期：2016-08-01 00:00:00

abstract：:Gene therapy mediated by murine leukemia virus (MLV)-based replicating retrovirus vector (RRV) was previously proven to be highly effective in tumor cell killing, resulting in significant suppression of tumor growth in vivo. Recently, we developed a different form of RRV which is derived from another retrovirus, gibbo...

journal_title：Oncology reports

authors： Lu YC,Chen YJ,Yu YR,Lai YH,Cheng JC,Li YF,Shen CH,Tai CK

更新日期：2012-07-01 00:00:00

abstract：:The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/β‑catenin pathway in regulating carbon ion (12C6+) radiation‑induced cellular toxicity. HLY78 is a Wnt‑specific small molecular modulator, whose effects on 12C6+ radiation‑induced damage ...

journal_title：Oncology reports

authors： Si J,Zhang J,Gan L,Guo M,Xie Y,Di C,Sun C,Wang F,Yan J,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:AZD8055 is a potent inhibitor of mTORC1 and mTOR2 and shows inhibitory effects in several types of cancer cells in vitro and in vivo. However, the effect of AZD8055 on hepatocellular carcinoma (HCC) cells has not been studied. We report that AZD8055 inhibits cell proliferation and colony formation of Hep3B and Huh7 ce...

journal_title：Oncology reports

authors： Hu M,Huang H,Zhao R,Li P,Li M,Miao H,Chen N,Chen M

更新日期：2014-02-01 00:00:00

abstract：:Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression o...

journal_title：Oncology reports

authors： Winnes M,Lissbrant E,Damber JE,Stenman G

更新日期：2007-05-01 00:00:00

abstract：:9-Oxo-10, 11-dehydroageraphorone (euptox A), a cadenine sesquiterpene, is the main toxin from Eupatorium adenophorum. The aim of the present study was to examine the induction and mechanism of HeLa cell apoptosis by euptox A. The apoptosis‑inducing effect of the euptox A on HeLa cells was examined by MTT assay. The un...

journal_title：Oncology reports

authors： Liao F,Hu Y,Wu L,Tan H,Luo B,He Y,Qiao Y,Mo Q,Wang Y,Zuo Z,Deng J,Wei Y

更新日期：2015-04-01 00:00:00

abstract：:Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) ex...

journal_title：Oncology reports

authors： Yamazaki H,Handa A,Nishi M,Tokunaga T,Tomisawa M,Hatanaka H,Abe Y,Kijima H,Ueyama Y,Nakamura M

更新日期：2004-02-01 00:00:00

abstract：:Minimal residual disease (MRD) is derived from tumor-initiating cells (TICs) and is responsible for tumor relapse. Neuroblastoma is characterized by extreme tumor heterogeneity, and more than half of high-risk patients experience tumor relapse. To overcome tumor heterogeneity and ac...

journal_title：Oncology reports

authors： Hartomo TB,Kozaki A,Hasegawa D,Van Huyen Pham T,Yamamoto N,Saitoh A,Ishida T,Kawasaki K,Kosaka Y,Ohashi H,Yamamoto T,Morikawa S,Hirase S,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H

更新日期：2013-04-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in cancer-related genes can act as low risk genetic factors for the development of this disease. SNPs have also been shown to influence the efficacy and toxicity of various cytotoxic agents used in the treatment of cancer. Progress in these important areas of cancer research reli...

journal_title：Oncology reports

authors： Grieu F,Joseph D,Norman P,Iacopetta B

更新日期：2004-02-01 00:00:00

abstract：:Long non‑coding RNA (lncRNA) forkhead box P4 antisense RNA 1 (FOXP4‑AS1) has been determined to function as an oncogene in various types of cancer. However, the biological function and the underlying mechanisms of FOXP4‑AS1 in mantle cell lymphoma (MCL) remain to be uncovered. The expression and the associated clinico...

journal_title：Oncology reports

authors： Tao HF,Shen JX,Hou ZW,Chen SY,Su YZ,Fang JL

更新日期：2020-12-11 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma. A20 and mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) are known to be related to DLBCL pathogenesis and progression. This study aimed to assess the effects of phorbol myristate acetate/ionomycin (PMA/IONO) on the growth a...

journal_title：Oncology reports

authors： Yang W,Li Y,Li P,Wang L

更新日期：2016-08-01 00:00:00

abstract：:Zoledronic acid (Zometa, ZOL) is increasingly used to treat tumour-induced bone disease, and is also reported to have antiangiogenic properties in vivo. In this study, we have investigated the correlations between changes in the proangiogenic cytokine, vascular endothelial growth factor (VEGF), and markers of bone res...

journal_title：Oncology reports

authors： Santini D,Vincenzi B,Hannon RA,Brown JE,Dicuonzo G,Angeletti S,La Cesa A,Coleman RE,Tonini G,Budillon A,Caraglia M,Holen I

更新日期：2006-05-01 00:00:00

abstract：:Eicosapentaenoic acid (EPA) is a dietary polyunsaturated fatty acid (PUFA) that is found abundantly in fish oils and induces apoptosis in human promyelocytic leukemia HL-60 cells. Cyclooxygenase (COX) converts EPA intracellularly into various inflammatory mediators that may affect the bioavailability of this fatty aci...

journal_title：Oncology reports

authors： Chiu LC,Tong KF,Ooi VE

更新日期：2004-01-01 00:00:00

abstract：:Following the publication of the above paper, an interested reader drew to our attention apparent anomalies associated with Figs. 2, 3 and 4; essentially, these three figures contained panels exhibiting overlapping data, such that data purportedly relating to different experiments were apparently drawn from the same o...

journal_title：Oncology reports

authors： Yang H,Zhan L,Yang T,Wang L,Li C,Zhao J,Lei Z,Li X,Zhang HT

更新日期：2020-11-25 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme which is endogenously expressed in germ, stem and tumor cells, but absent in benign somatic cells. The two major telomerase components are human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT). It has been shown that hTERT is rate-limiting for telomerase...

journal_title：Oncology reports

authors： Schrader M,Burger AM,Müller M,Krause H,Straub B,Smith GL,Newlands ES,Miller K

更新日期：2002-09-01 00:00:00

abstract：:Although ascorbate (Vitamin C) has been shown to inhibit cell growth and induce cell death in variety of cancer cells, results reported in other studies are inconsistent with this conclusion. It was previously reported that ascorbate induces apoptosis in human breast cancer cells. However, the molecular mechanism for ...

journal_title：Oncology reports

authors： Hong SW,Jin DH,Hahm ES,Yim SH,Lim JS,Kim KI,Yang Y,Lee SS,Kang JS,Lee WJ,Lee WK,Lee MS

更新日期：2007-10-01 00:00:00

abstract：:Ultraviolet (UV) radiation is the primary risk factor underlying photoaging and photocarcinogenesis. Mounting research has focused on the role of DNA damage response pathways in UV-induced double-strand break (DSB) repair. In the present study, we hypothesized that UVA-induced aberrant progerin upregulation may advers...

journal_title：Oncology reports

authors： Huang X,Pan Y,Cao D,Fang S,Huang K,Chen J,Chen A

更新日期：2017-06-01 00:00:00

abstract：:EVL belongs to the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family of proteins [Mena (mammalian Ena), VASP and EVL], which have a range of roles in regulating the actin cytoskeleton. Growing evidence suggests that Mena and VASP are involved in carcinogenesis, though little is known about the significan...

journal_title：Oncology reports

authors： Hu LD,Zou HF,Zhan SX,Cao KM

更新日期：2008-04-01 00:00:00

abstract：:The efficacy of chemotherapy for hepatocellular carcinoma (HCC) remains unsatisfactory, primarily due to inherent self‑defense mechanisms (e.g., mitophagy and autophagy). In the present study, we aimed to explore the pro‑apoptotic effects of targeting mitophagy to potentiate the efficacy of chemotherapy for HCC. HCC c...

journal_title：Oncology reports

authors： Ma M,Lin XH,Liu HH,Zhang R,Chen RX

更新日期：2020-03-01 00:00:00

abstract：:Alterations in DNA methylation have a central role in the development and outcome of most human malignancies. Non‑small cell lung cancer (NSCLC), the most common lung cancer, leads to the largest number of cancer‑related deaths worldwide. FBJ murine osteosarcoma viral oncogene homolog B (FOSB) is a key component of th...

journal_title：Oncology reports

authors： Kim DS,Lee WK,Park JY

更新日期：2020-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchym...

journal_title：Oncology reports

authors： Peng G,Tang Z,Xiang Y,Chen W

更新日期：2019-02-01 00:00:00

abstract：:The impact of interferon-γ (IFN-γ) late preconditioning on myocardial ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and the underlying mechanism were investigated. Using a porcine model of myocardial ischemia-reperfusion injury during CPB with a 60-min aorta cross-clamp, 20 pigs (15±0.5 kg) were trea...

journal_title：Oncology reports

authors： Yan X,Qiu W,Jia B,Zhong H,Li X,Chen Z

更新日期：2013-11-01 00:00:00

abstract：:Retinoblastoma, a well-vascularized tumor that is dependent on a very robust angiogenic response, is the most common intraocular malignancy in children. Tissue factor (TF) is known to regulate tumor progression and in the present study we demonstrated that TF regulates tumor angioge...

journal_title：Oncology reports

authors： Song HB,Park KD,Kim JH,Kim DH,Yu YS,Kim JH

更新日期：2012-12-01 00:00:00

abstract：:The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...

journal_title：Oncology reports

authors： Guo B,Hui Q,Zhang Y,Chang P,Tao K

更新日期：2016-10-01 00:00:00

abstract：:Targeted gene therapy needs to be implemented for future therapies to ensure efficient activity at the site of patient primary tumors or metastases without causing intolerable side-effects. One of the elements of gene therapy is vector, which includes viral and non-viral vector. In the present study, we constructed a ...

journal_title：Oncology reports

authors： Zuo Y,Liao S,Xu Z,Xie J,Huang W,Yu Z

更新日期：2014-12-01 00:00:00

abstract：:While Taxol has been reported to improve the clinical survival of breast cancer patients, subsequently developed drug-resistance of the cancer cells limits its final efficacy and applications. Previous studies suggested that Aurora A is involved in the development of the Taxol-resistance of breast cancer. We establish...

journal_title：Oncology reports

authors： Li Y,Zhou W,Tang K,Chen X,Feng Z,Chen J

更新日期：2017-10-01 00:00:00

abstract：:In a human cancer cell line, we previously found a mutation in codon 322 of the extracellular signal-regulated kinase (ERK2E322K), the protein showed a faster migration when compared to wild-type in SDS-PAGE and constitutive phosphorylation. However, the reason for the faster migration, and the biochemical and biologi...

journal_title：Oncology reports

authors： Mahalingam M,Arvind R,Ida H,Murugan AK,Yamaguchi M,Tsuchida N

更新日期：2008-10-01 00:00:00

abstract：:Evidence has shown that microRNAs play important roles in tumor development, progression, and metastasis. miR-128 has been reported to be deregulated in different tumor types, whereas the function of miR-128 in colorectal carcinoma (CRC) largely remains to be elucidated. The aim of the present study was to investigate...

journal_title：Oncology reports

authors： Wu L,Shi B,Huang K,Fan G

更新日期：2015-11-01 00:00:00