Vaccination of mice with lipopolysaccharide (LPS) and LPS-derived immuno-conjugates from Leptospira interrogans.

Abstract:

:Mice were vaccinated with lipopolysaccharide (LPS) from Leptospira interrogans serovar pomona or hardjo, or with the polysaccharide (PS) fraction of the LPS, or with an immunoconjugate of PS and diphtheria toxoid (DT). Maximum agglutinin titres were found 6-10 weeks after vaccination with LPS or PS-DT conjugate; the latter elicited antibody titres at least 10 times higher than those produced in response to LPS. Animals failed to react significantly to PS. Titres elicited by antigens of serovar pomona were higher than those elicited by serovar hardjo.

journal_name

J Med Microbiol

authors

Midwinter A,Faine S,Adler B

doi

10.1099/00222615-33-3-199

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

199-204

issue

3

eissn

0022-2615

issn

1473-5644

journal_volume

33

pub_type

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