Abstract:
:Mice were vaccinated with lipopolysaccharide (LPS) from Leptospira interrogans serovar pomona or hardjo, or with the polysaccharide (PS) fraction of the LPS, or with an immunoconjugate of PS and diphtheria toxoid (DT). Maximum agglutinin titres were found 6-10 weeks after vaccination with LPS or PS-DT conjugate; the latter elicited antibody titres at least 10 times higher than those produced in response to LPS. Animals failed to react significantly to PS. Titres elicited by antigens of serovar pomona were higher than those elicited by serovar hardjo.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Midwinter A,Faine S,Adler Bdoi
10.1099/00222615-33-3-199subject
Has Abstractpub_date
1990-11-01 00:00:00pages
199-204issue
3eissn
0022-2615issn
1473-5644journal_volume
33pub_type
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