Abstract：
AIM:To investigate whether in lower extremity lymphoedema, lymph proteins enter blood before they do the thoracic duct. METHODS:Retrospective analysis of routine lymphoscintigraphy in 69 adults imaged at 5, 45 and 150 min following bilateral subcutaneous web space injection of Tc-nanocolloid was carried out. Regions of interest were placed over the liver and ilioinguinal lymph nodes bilaterally on the anterior images at 45 and 150 min. Individual minor (0.5 point for each) and major (1 point for each) criteria of abnormal scintigraphy were applied to each limb and summed to give a lymphoscintigraphic abnormality score. An abnormal limb had a score ≥1. RESULTS:The ratio of hepatic counts per pixel to total bilateral ilioinguinal counts (L/N ratio) was higher in patients with abnormal results on lymphoscintigraphy (median 6.2; interquartile range 4.0-15.6 pixels×10; n=48) compared with that in patients with normal lymphoscintigraphic results (2.5 [1.5-5.0] pixels×10; n=21; P<0.0002). In the abnormal group, the lymphoscintigraphic score (two limbs summed) correlated with the 150-min L/N ratio (r s=0.42; P<0.005). L/N ratios at 45 and 150 min correlated in the abnormal group (r s=0.44; P<0.005) but not in the normal group (r s=0.3; P>0.05). The 45-min activity, as a percentage of the 150-min activity, was higher in lymph nodes than in the liver in both the abnormal (35.0 [8.2-50.0] vs. 10.6 [5.8-30.0]%; P<0.0001]) and normal groups (38.3 [18.4-63.5] vs. 23.3 [12.4-33.1]%; P<0.05), and, with respect to the liver, was higher in the normal group (P<0.01). CONCLUSION:In lymphoedema, more lymph proteins enter blood proximal to the thoracic duct. The time courses of nodal and hepatic activities suggest that access may occur within nodes themselves.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Stamp GF,Peters AMdoi
10.1097/MNM.0b013e32835313d4subject
Has Abstractpub_date
2012-07-01 00:00:00pages
701-7issue
7eissn
0143-3636issn
1473-5628journal_volume
33pub_type
杂志文章abstract：:Positron emission tomography (PET) using F-18 fluoro-3'-deoxy-3-L-fluorothymidine (FLT) offers noninvasive assessment of cell proliferation in vivo. The most important application refers to the evaluation of tumour proliferative activity, representing a key feature of malignancy. Most data to date suggest that FLT is ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章,评审
doi：10.1097/MNM.0b013e32832ee93b
更新日期：2009-12-01 00:00:00
abstract：INTRODUCTION:The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction. We report here on the rhesus monk...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e3283060c72
更新日期：2008-10-01 00:00:00
abstract：:The application of a Well-type germanium semiconductor detector creates new possibilities in erythrocyte survival studies. Using 51Cr, the effective dose equivalent in a standard procedure can be reduced from approximately 780 to 2 microSv. The properties of the detector, namely, high efficiency and high energy resolu...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199105000-00010
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:A new kinetic model of technetium-99m-labeled diethylenetriaminepentaacetic acid-galactosyl human serum albumin (Tc-GSA) was developed to show the speed of asialoglycoprotein receptor-mediated endocytosis. MATERIALS AND METHODS:Ten healthy volunteers and 17 patients with liver cirrhosis were intravenously i...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/MNM.0b013e328362e7c7
更新日期：2013-09-01 00:00:00
abstract：:Thirty patients with aortic valve incompetence and 21 control subjects were examined by M-mode echocardiography at rest and radionuclide ventriculography during submaximal handgrip exercise. The patients had greater left ventricular dimensions and end-systolic wall stress values but peak systolic wall stress values di...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199004000-00004
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:The indication for sentinel node biopsy (SNB) has not been fully established yet for patients with ductal carcinoma in situ (DCIS). AIM:To relate the conversion rate to invasive carcinoma with sentinel node positivity in high risk DCIS, and to refine the clinical presentation analysis in order to better sel...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/01.mnm.0000230074.39071.bf
更新日期：2006-10-01 00:00:00
abstract：:The purpose of this study was to validate different scintigraphic approaches for assessing acute myocardial infarctions. 201Tl, 99Tcm pyrophosphate (PPi) and combined 201Tl/99Tcm PPi tomograms were evaluated in 115 consecutive patients, in 85 of whom clinical examination revealed acute myocardial infarction. The overa...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199009000-00005
更新日期：1990-09-01 00:00:00
abstract：:The aim of this study was to demonstrate that radionuclide sentinel node detection can be applied to patients with non-palpable breast cancer. One hundred and ten consecutive women with unilateral breast cancer were studied. Group 1 was made up of 80 patients with palpable breast cancer (mean age, 58 years) and group ...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/00006231-200212000-00003
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the diagnostic accuracy of PET/computed tomography (CT) in detecting marrow infiltration in indolent non-Hodgkin lymphoma (NHL) with histopathological correlation. METHODS:All treatment-naive newly diagnosed indolent NHL with staging PET/CT were retrospectively evaluated for marrow infiltration a...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000361
更新日期：2015-10-01 00:00:00
abstract：:123I-labelled 15-(p-iodophenyl)-9-(R,S)-methylpentadecanoic acid (9MPA) is a modified long-chain fatty acid that shows some beta-oxidation. Some basic aspects of this fatty acid, including myocardial uptake, distribution, clearance and differences from 201Tl myocardial perfusion, have yet to be evaluated. An average o...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199809000-00004
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:90Y is one of the radioisotopes used extensively for therapy due to its favourable nuclear characteristics. Particles and colloids incorporating 90Y are being used for radiation synovectomy, especially in European countries. METHODS:In our present work, 90Y phosphate particles were prepared and evaluated fo...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-200505000-00011
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVES:This survey was designed to assess the trends in the frequencies of nuclear medicine procedures in the UK and to determine their contributions to the annual collective effective dose to the UK population. The average activities administered by nuclear medicine departments were compared with guidance on diagn...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/01.mnm.0000184939.28994.f9
更新日期：2005-11-01 00:00:00
abstract：:The study of the kinetics of labelled platelets makes sense only when the platelets preserve their viability after separation and labelling. The separation and labelling procedures described in the manual of two producers of 111In-oxinate (Amersham, Mallinckrodt) have been evaluated by in vitro aggregation tests. The ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：INTRODUCTION:Diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) using conventional imaging techniques can be difficult; however, it is important to differentiate between them as these benign liver tumors require different therapeutic strategies. The aim of our study was to prospectively evalu...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/MNM.0b013e32835afe62
更新日期：2013-02-01 00:00:00
abstract：:We have assessed the usefulness of a radionuclide dilution method for estimation of ascitic fluid volume. 99Tc(m) macroaggregated albumin (10 MBq) was injected into the peritoneal fluid. Multiple samples were taken using a trocath peritoneal dialysis catheter over a 4-h period. Blood samples were taken at the same tim...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/00006231-200012000-00009
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Measurement errors occurring during glomerular filtration rate (GFR) studies propagate to an error in the calculated GFR. Previous work has modelled measurement errors for slope-intercept (SI-GFR), single-sample (SS-GFR) and slope-only (SO-GFR) methods. In this study, we have extended these models. The prima...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000977
更新日期：2019-04-01 00:00:00
abstract：:The aim of this study was to define indices which could be used to assess the quality of care of children undergoing an examination requiring intravenous (i.v.) access in an integrated department of radiology and to see if these indices could be quantified. A prospective study of all patients requiring an i.v. injecti...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:It is generally accepted that the quality of myocardial images deteriorates with increasing patient weight. This is attributed to a reduction of counts detected from the myocardium. In this paper we have looked at the count reduction in obese patients and suggest a workable algorithm to increase the injected activity ...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00006231-200301000-00015
更新日期：2003-01-01 00:00:00
abstract：:Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients....
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-198710000-00003
更新日期：1987-10-01 00:00:00
abstract：OBJECTIVES:In this study, we evaluated and compared the level of myocardial ischaemia caused by cardiac syndrome X (CSX) and coronary slow flow (CSF) with single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI), and determined if changes in the level of myocardial ischaemia exist in CSF and ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000001080
更新日期：2019-11-01 00:00:00
abstract：:Ion-exchange resin beads, implanted into connective tissue, were used as the vehicle for the delivery of radiolabelled cations to determine the local distribution of lead, silver and cadmium in loose connective tissue. The system was devoid of systemic toxicity, permitted a predictable release, enabled location of rel...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-198806000-00003
更新日期：1988-06-01 00:00:00
abstract：PURPOSE:Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomograp...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/MNM.0000000000001086
更新日期：2019-11-01 00:00:00
abstract：:An analysis of lymphocyte subsets was performed in 24 patients with surgically verified unresectable hepatocellular carcinoma (HCC). In all cases, the hepatic artery was cannulated and ligated and a single dose of 131I-Hepama-1 monoclonal antibody (MAb) was infused through a hepatic artery catheter. Blood samples were...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/00006231-199505000-00010
更新日期：1995-05-01 00:00:00
abstract：:To make quantitative methods of nuclear medicine more available, four centres in Croatia participated in the national intercomparison study, following the materials and methods used in the previous international study organized by the International Atomic Energy Agency (IAEA). The study task was to calculate the activ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章,多中心研究
doi：10.1097/MNM.0000000000000877
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to assess the relevance of physiological In-octreotide uptake in the head of pancreas and to establish its imaging features in comparison with pathological uptake in patients with neuroendocrine tumors (NET). PATIENTS AND METHODS:We retrospectively reviewed all patients that underw...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000710
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:Single-photon emission computed tomography ventilation/perfusion (SPECT V/Q) imaging is recommended both by the Society of Nuclear Medicine and by the European Association of Nuclear Medicine for the diagnosis of pulmonary embolism. However, respiratory motion produces image blurring and degradation of detai...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000015
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the diagnostic value of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT in comparison with MRI for the detection of recurrent ovarian cancer. METHODS:Forty-seven patients with suspected ovarian cancer recurrence after total ablative or cytoreductive surgery, ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e32834fc5bf
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVES:Computed tomography (CT) automatic exposure control (AEC) systems are now used in all modern PET-CT scanners. A collaborative study was undertaken to compare AEC techniques of the three major PET-CT manufacturers for fluorine-18 fluorodeoxyglucose half-body oncology imaging. MATERIALS AND METHODS:An audit o...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000064
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:Lymphoid hyperplasia is not uncommon in the midline roof of the nasopharynx. Most nasopharyngeal carcinoma patients present with primary tumors in the midline of the nasopharynx. The aim of this study was to evaluate the efficacy of 2-[fluorine-18] fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/computed tomography (C...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/MNM.0000000000000141
更新日期：2014-09-01 00:00:00
abstract：:Heart uptake and clearance of 123I-15-(p-iodophenyl)-3(R,S)-methyl- pentadecanoic acid (BMIPP) by whole-body scintigraphy in relation to left ventricular ejection fraction (LVEF) was evaluated in 34 patients with ischaemic heart disease. At 45 and 210 min after injection, anterior whole-body images were obtained. In e...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/00006231-199409000-00004
更新日期：1994-09-01 00:00:00
