Abstract:
BACKGROUND:Measurement errors occurring during glomerular filtration rate (GFR) studies propagate to an error in the calculated GFR. Previous work has modelled measurement errors for slope-intercept (SI-GFR), single-sample (SS-GFR) and slope-only (SO-GFR) methods. In this study, we have extended these models. The primary aims were to (i) compare measurement errors in two-sample SI-GFR, three-sample SI-GFR, SS-GFR and SO-GFR, and (ii) determine the sensitivity of GFR to errors arising from different measurements. PATIENTS AND METHODS:This study expanded on previous models of GFR measurement error incorporating biological data from 786 patients and realistic measurement errors. GFR median absolute error and the coefficient of variation (CV) were calculated for each method. A sensitivity analysis was carried out for individual measurement errors. RESULTS:The median absolute error ranged between 1.2 and 2.3 ml/min/1.73 m, lowest for SS-GFR (4 h) and highest for SO-GFR. At higher rates of clearance, CV was less than 5% for all methods. CV increased rapidly when GFR decreased below a threshold ranging between 34 and 56 ml/min/1.73 m, lowest for three-point SI-GFR and highest for SO-GFR. SI-GFR and SS-GFR are most sensitive to injected activity quantification, but less sensitive to other measurement errors. CONCLUSION:Measurement errors are probably insignificant relative to biological variation for GFR of more than 60 ml/min/1.73 m, but become significant irrespective of biological variation at lower GFR, particularly in serial studies when GFR less than 25 ml/min/1.73 m. Limits of precision recommended in the 2018 British Nuclear Medicine Society guideline are appropriate for once-off GFR measurement, whereas slightly more stringent limits are proposed for serial studies.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Holness JL,Fleming JS,Chirehwa MT,Warwick JMdoi
10.1097/MNM.0000000000000977subject
Has Abstractpub_date
2019-04-01 00:00:00pages
333-342issue
4eissn
0143-3636issn
1473-5628journal_volume
40pub_type
杂志文章abstract:OBJECTIVES:(68)Ga-Dotatoc has become the PET radiopharmaceutical of choice for the diagnosis and treatment follow-up of neuroendocrine tumours. (68)Ga-Dotatoc is prepared on-site through a so-called magisterial preparation. The use of an appropriate buffer during the radiolabelling step is essential to maximize the lab...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32833acb99
更新日期:2010-08-01 00:00:00
abstract:AIM:The aim of this study was to design a general nuclear medicine method for fast, accurate and direct determination of the clearance of a radioactive indicator provided that all uptake compartments of the radioactive indicator could be included in the field of view of the gamma camera. METHODS:The data material for ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200410000-00006
更新日期:2004-10-01 00:00:00
abstract::This study surveyed practice in nuclear cardiology in the UK in 1994. A questionnaire was sent to 219 centres performing nuclear imaging asking for details of current practice in nuclear cardiology. Replies were received from 192 centres (88%). Activity in performance of myocardial perfusion imaging (MPI) and radionuc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199804000-00004
更新日期:1998-04-01 00:00:00
abstract::Using radionuclide methods the relationship between total and central blood volume and left ventricular function was studied in 12 patients with untreated essential hypertension and contrasted with the findings in eight normotensive subjects. The principal findings were of an increased stroke volume and end-diastolic ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198410000-00002
更新日期:1984-10-01 00:00:00
abstract::A new radiopharmaceutical for hepatobiliary scanning, 99Tcm Iodida, which has significant advantages in patients with high bilirubinaemia, was used to assess biliary tract complications in 30 consecutive liver transplant patients. There was adequate hepatic extraction and excretion for diagnostic imaging even in patie...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199011000-00005
更新日期:1990-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the clinical role of technetium-99m pertechnetate (Tc-99m) imaging in thyroidectomized differentiated thyroid cancer patients immediately before radioiodine-131 (I-131) treatment (Tx). PATIENT AND METHODS:Eighty-six consecutive post-total-thyroidectomy patients (15 men, 71...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000426
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to identify deficiencies in product labelling instructions for reconstitution and in the quality control directions detailed in the technical leaflets (TLs) or summary product characteristic (SPC) sheets of commonly used technetium labelling cold kits. MATERIALS AND METHODS:The recon...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000030
更新日期:2014-02-01 00:00:00
abstract::Twelve patients with a diagnosis of schizophrenia and thirteen control subjects were injected with 77Br-bromospiperone and scanned using single photon emission tomography after 16 h. Although a statistically significant increase in patients by comparison with controls could be demonstrated, wide variations in specific...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198608000-00006
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:In studies of the distribution of lung function, the image quality of lung single photon emission computed tomography (SPECT) is important and one factor influencing it is the reconstruction algorithm. AIM:To systematically evaluate ordered subsets expectation maximization (OSEM) and compare it with filtere...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f1acac
更新日期:2007-12-01 00:00:00
abstract:INTRODUCTION:In the present study, (99m)Tc-radiolabelled E-selectin binding peptide ((99m)Tc-IMP-178) was investigated for its potential to image acute pyogenic osteomyelitis in a new animal model. Intraindividual comparisons were performed using an irrelevant peptide ((99m)Tc-IMP-100) to demonstrate specificity. METH...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200109000-00010
更新日期:2001-09-01 00:00:00
abstract:AIM:This study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patien...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000202866.97787.45
更新日期:2006-04-01 00:00:00
abstract::An examination of the biokinetics and biodistribution of i.p. administered 131I- or 111In-labelled 791T/36 antibody (1 mg) has been carried out in five patients with stage III/IV ovarian cancer. Blood kinetics and urinary excretion of the radiolabels were assayed. Scintigraphy was performed immediately following admin...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198908010-00006
更新日期:1989-08-01 00:00:00
abstract::Micturating renograms often need to be carried out on children, with whom difficulty may be experienced in synchronizing onset of micturition with camera and computer acquisition. A flow detection system has been developed which will automate these acquisitions, resulting in far fewer false starts or lost studies. The...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198709000-00003
更新日期:1987-09-01 00:00:00
abstract::The aim of this prospective study was to assess the efficacy of using whole-kidney, mean parenchymal and pelvic transit times to evaluate renal function following treatment with extracorporeal shock wave lithotripsy (ESWL). Fifteen patients were evaluated 24-48 h before and after ESWL therapy using 99Tcm-DTPA renal sc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199802000-00010
更新日期:1998-02-01 00:00:00
abstract::In addition to imaging, radionuclide venography can be used for studying haemodynamic changes in superior vena cava syndrome (SVCS) by using the indices of transit time (TT), time of half peak count (TH) and peak count ratio (PC ratio). The objective of this study was to examine the utility of applying these indices, ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199805000-00003
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine the fraction of administered activity that was excreted and retained by a small cohort of patients who each received treatment with radium-223 dichloride (Ra). Ra is an α-emitting radionuclide that has been approved for use in the treatment of bone metastases that are sec...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000783
更新日期:2018-02-01 00:00:00
abstract::Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have advanced our understanding of the biological underpinnings of depression. There is, however, considerable variability in the literature. Depression is a complex disorder with marked heterogeneity in diagnosis and treatment. ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-200503000-00004
更新日期:2005-03-01 00:00:00
abstract::The uptake of 123I-5-iodo-2-thiouracil in melanotic and amelanotic melanoma implanted in Syrian golden hamsters was studied. A selective accumulation was found in the tumours. Uptake of 123ITU in melanotic melanomas was 4 to 5 times the uptake in amelanotic ones. For both tumours high ratios of tumours versus non-tumo...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198510000-00007
更新日期:1985-10-01 00:00:00
abstract::System upgrades are a constant feature of many highly technical specialties and are normally assumed to have a negligible effect on patient data. We report on the assessment of an upgrade made to a Norland XR-26 dual-energy X-ray absorptiometry (DXA) system. The upgraded version (2.3) consisted of new hip positioning ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199604000-00161
更新日期:1996-04-01 00:00:00
abstract::Mobile PET/CT or mobile stand alone PET, is becoming more widely available throughout the developed world, allowing many small and medium-sized hospitals that do not have the scale or financial resources to purchase the static diagnostic equipment, to benefit from this imaging technology. Before embarking on such a se...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e3282f25919
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS:A total of 109 patients with typical angina and no previous coronary artery di...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000739
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To analyse the kinetic changes of uptake, washout and retention of Tc-sestamibi in order to evaluate the protective effects and possible mechanism of ischaemic preconditioning and adenosine preconditioning on myocardium injured by ischaemia/reperfusion. METHODS:Isolated ischaemia/reperfusion rabbit heart mod...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f1781b
更新日期:2007-11-01 00:00:00
abstract::Patients with acute arterial occlusion may suffer from significant muscle necrosis. It is important to determine the amount of regional muscle necrosis for prognostic purposes and evaluation of therapy. We have used technetium-99m-pyrophosphate (PPi) with single photon emission computed tomography (SPECT) to quantitat...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199002000-00009
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is known that fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) segmentation algorithms have an impact on the metabolic tumor volume (MTV). This leads to some uncertainties in PET/CT guidance of tumor radiotherapy. The aim of this study was to investigate the effect of segmentation a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000641
更新日期:2017-03-01 00:00:00
abstract::The range of leucocyte labelling efficiencies with 111In-oxine for a group of patients extended significantly (P = 0.05) below that obtained for a series of labellings of the same normal blood from a volunteer. A retrospective analysis was made of the results in the two groups to identify the cause of this difference ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
abstract::In 70 patients with angiographically confirmed coronary heart disease and in 10 controls, a 4 h exercise (E) (injection of 150 MBq 99Tcm-MIBI) rest (R) (800 MBq) protocol was employed. Of these, 10 patients with 21 myocardial defects after E received a third injection 24 h after. SPECT was used to image myocardial dis...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199002000-00002
更新日期:1990-02-01 00:00:00
abstract::(99m)Tc dimercaptosuccinic acid (DMSA) renal scans can provide accurate diagnosis of acute pyelonephritis, its sequelae (renal scars) and differential renal function (DRF). The purposes of this retrospective study were (1) to assess the relationship between DRF obtained during acute pyelonephritis and at follow-up, an...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200210000-00011
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:Myocardial perfusion SPECT is frequently affected by artefacts related to abdominal activity. Metoclopramide has been suggested to relieve this, but two previous studies have shown conflicting results. METHODS:Ninety-five patients received 10 mg metoclopramide orally after injection of 99mTc-tetrofosmin for...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.mnm.0000243368.73141.61
更新日期:2006-12-01 00:00:00
abstract::This work was designed to compare sentinel lymph node (SLN) uptake of 99mTc-labelled human serum albumin colloid (99mTc-HSAC), 99mTc-labelled antimony sulphur colloid (99mTc-SC) and a 99mTc-labelled dextran 70 solution (99mTc-Dx) and their selectivity in the identification of this node in the right rear footpad (RRF) ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200105000-00006
更新日期:2001-05-01 00:00:00
abstract::We evaluated the clinical usefulness of 99Tcm-N,N-ethylenedicysteine (99Tcm-EC), a new renal tubular agent, in normal children and in children with various renal disorders and compared it with 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In a first group of children (Group 1), which included 15 patients and 4 normal c...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199701000-00009
更新日期:1997-01-01 00:00:00