Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese.

abstract：:Blood is an ideal window for viewing our health and disease status. Because blood circulates throughout the entire body and carries secreted, shed, and excreted signature proteins from every organ and tissue type, it is thus possible to use the blood proteome to achieve a comprehensive assessment of multiple-organ phy...

journal_title：Journal of proteome research

authors： Sun B,Utleg AG,Hu Z,Qin S,Keller A,Lorang C,Gray L,Brightman A,Lee D,Alexander VM,Ranish JA,Moritz RL,Hood L

更新日期：2013-05-03 00:00:00

abstract：:The current report describes the use of CapLC-ESI-Q/TOF-MS for investigating the proteome profiles of hypertonic saline-induced sputum samples from 56 smokers. The severity of their lung disease ranged from normal (healthy smokers) to chronic bronchitis, chronic obstructive pulmonary disease (COPD), and COPD with emph...

journal_title：Journal of proteome research

authors： Casado B,Iadarola P,Pannell LK,Luisetti M,Corsico A,Ansaldo E,Ferrarotti I,Boschetto P,Baraniuk JN

更新日期：2007-12-01 00:00:00

abstract：:Butyrate, a fermentation product of the large bowel microflora, is potentially protective against the development of colorectal cancer. In vitro, butyrate has been shown to induce apoptosis and inhibit proliferation in numerous cancer cell lines, including colorectal cancer. Although these tumor suppressing properties...

journal_title：Journal of proteome research

authors： Fung KY,Lewanowitsch T,Henderson ST,Priebe I,Hoffmann P,McColl SR,Lockett T,Head R,Cosgrove LJ

更新日期：2009-03-01 00:00:00

abstract：:Clostridioides difficile-associated infection (CDI) is a health-care-associated infection caused, as the name suggests, by obligate anaerobic pathogen C. difficile and thus mainly transmitted via highly resistant endospores from one person to the other. In vivo, the spores need to germinate into cells prior to establi...

journal_title：Journal of proteome research

authors： Abhyankar WR,Zheng L,Brul S,de Koster CG,de Koning LJ

更新日期：2019-11-01 00:00:00

abstract：:Adipose tissue is a major storage site for lipophilic environmental contaminants. The environmental metabolic disruptor hypothesis postulates that some pollutants can promote obesity or metabolic disorders by activating nuclear receptors involved in the control of energetic homeostasis. In this context, monoethylhexyl...

journal_title：Journal of proteome research

authors： Ellero-Simatos S,Claus SP,Benelli C,Forest C,Letourneur F,Cagnard N,Beaune PH,de Waziers I

更新日期：2011-12-02 00:00:00

abstract：:Mequindox is used as a veterinary antibiotic drug. As part of systematic investigations into mequindox as a veterinary medicine and its subsequent applications in food safety, we conducted the investigation to assess the metabolic response of mice to mequindox using metabonomics, which combines NMR metabolic profiles ...

journal_title：Journal of proteome research

authors： Zhao XJ,Huang C,Lei H,Nie X,Tang H,Wang Y

更新日期：2011-11-04 00:00:00

abstract：:Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells and mediates multiple cellular signaling pathways. In the present study, a 35% decrease of cellular NAD level is achieved by stable expression of the N-terminal truncated CD38, a NAD hydrolase. CD38-expressing (CD38(+)) cells have the lowe...

journal_title：Journal of proteome research

authors： Hu Y,Wang H,Wang Q,Deng H

更新日期：2014-02-07 00:00:00

abstract：:The present study reports an in-depth proteome analysis of two Lactobacillus rhamnosus strains, the well-known probiotic strain GG and the dairy strain Lc705. We used GeLC-MS/MS, in which proteins are separated using 1-DE and identified using nanoLC-MS/MS, to generate high-quality protein catalogs. To maximize the num...

journal_title：Journal of proteome research

authors： Savijoki K,Lietzén N,Kankainen M,Alatossava T,Koskenniemi K,Varmanen P,Nyman TA

更新日期：2011-08-05 00:00:00

abstract：:Microorganisms release effector molecules that modulate the host machinery enabling survival, replication, and dissemination of a pathogen. Here we characterized the extracellular proteome of Paracoccidioides brasiliensis at its pathogenic yeast phase. Cell-free culture supernatants from the Pb18 isolate, cultivated i...

journal_title：Journal of proteome research

authors： Vallejo MC,Nakayasu ES,Matsuo AL,Sobreira TJ,Longo LV,Ganiko L,Almeida IC,Puccia R

更新日期：2012-03-02 00:00:00

abstract：:14-3-3s are phosphoserine/phosphotreonine binding proteins that play pivotal roles as regulators of multiple cellular processes in eukaryotes. The flagellated protozoan parasite Giardia duodenalis, the causing agent of giardiasis, is a valuable simplified eukaryotic model. A single 14-3-3 isoform (g14-3-3) is expresse...

journal_title：Journal of proteome research

authors： Lalle M,Camerini S,Cecchetti S,Sayadi A,Crescenzi M,Pozio E

更新日期：2012-05-04 00:00:00

abstract：:Gastric cancer (GC) is among the most common cancers worldwide. Gastric carcinogenesis is a multistep and multifactorial process beginning with chronic gastritis induced by Helicobacter pylori (H. pylori) infection. This process is often described via a sequence of events known as Correas's cascade, a stepwise progres...

journal_title：Journal of proteome research

authors： Kuligowski J,Sanjuan-Herráez D,Vázquez-Sánchez MA,Brunet-Vega A,Pericay C,Ramírez-Lázaro MJ,Lario S,Gombau L,Junquera F,Calvet X,Quintás G

更新日期：2016-08-05 00:00:00

abstract：:Bridging conduits (BC) are tubular protrusions that facilitate cytoplasm and membrane exchanges between tethered cells. We now report that the human immunodeficiency virus type I (HIV-1) exploits these conduits to accelerate its spread and to shield it from immune surveillance. Endosome transport through BC drives HIV...

journal_title：Journal of proteome research

authors： Kadiu I,Gendelman HE

更新日期：2011-07-01 00:00:00

abstract：:Bacillus Amyloliquefaciens SQR9 is a well-investigated plant growth-promoting rhizobacteria with strong root colonization capability. To identify the key proteins involved in in situ root colonization and biofilm formation, the proteomic profiles of planktonic and root colonized SQR9 cells were compared. A total of 75...

journal_title：Journal of proteome research

authors： Qiu M,Xu Z,Li X,Li Q,Zhang N,Shen Q,Zhang R

更新日期：2014-12-05 00:00:00

abstract：:The exact impact of bariatric surgery in metabolically "healthy" (MH) or "unhealthy" (MU) phenotypes for the study of the metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF-MS-driven metabolomics approach in serum samples from 39 patients with morbid obesity (MH and MU) 1, 3, and 6 month...

journal_title：Journal of proteome research

authors： Palau-Rodriguez M,Tulipani S,Marco-Ramell A,Miñarro A,Jauregui O,Gonzalez-Dominguez R,Sanchez-Pla A,Ramos-Molina B,Tinahones FJ,Andres-Lacueva C

更新日期：2018-08-03 00:00:00

abstract：:As central tissue of glucose homeostasis, islet has been an important focus of diabetes research. Phosphorylation plays pivotal roles in islet function, especially in islet glucose-stimulated insulin secretion. A systematic view on how phosphorylation networks were coordinately regulated in this process remains lackin...

journal_title：Journal of proteome research

authors： Li J,Li Q,Tang J,Xia F,Wu J,Zeng R

更新日期：2015-11-06 00:00:00

abstract：:Seminoma and embryonal carcinoma (EC), two typical types of testicular germ cell tumors (TGCTs), present significant differences in growth behavior, expression characteristics, differentiation potential, clinical features, therapy, and prognosis. The purpose of this study was to compare the distinctive or preference m...

journal_title：Journal of proteome research

authors： Batool A,Chen SR,Liu YX

更新日期：2019-04-05 00:00:00

abstract：:Epithelial cells play an important role in physiological and pathophysiological situations, with organ-, tissue-, type-, and function-specific patterns. Proteome analysis has been used to study epithelial-origin diseases and identify novel prognostic, diagnostic, and therapeutic markers. The present review compares th...

journal_title：Journal of proteome research

authors： Zhao H,Adler KB,Bai C,Tang F,Wang X

更新日期：2006-04-01 00:00:00

abstract：:Although the legume-rhizobium symbiosis is a most-important biological process, there is a limited knowledge about the protein interaction network between host and symbiont. Using interolog- and domain-based approaches, we constructed an interspecies protein interactome containing 5115 protein-protein interactions bet...

journal_title：Journal of proteome research

authors： Zhang L,Liu JY,Gu H,Du Y,Zuo JF,Zhang Z,Zhang M,Li P,Dunwell JM,Cao Y,Zhang Z,Zhang YM

更新日期：2018-09-07 00:00:00

abstract：:The effects of acute and chronic stress on the production of systemic metabolites were investigated in male Sprague-Dawley (SD) rats. Metabolites excreted in urine were analyzed using GC/MS in conjunction with multivariate and univariate statistical techniques. SD rats were subjected to two kinds of acute stress and c...

journal_title：Journal of proteome research

authors： Wang X,Zhao T,Qiu Y,Su M,Jiang T,Zhou M,Zhao A,Jia W

更新日期：2009-05-01 00:00:00

abstract：:The Biology/Disease-driven (B/D) working groups of the Human Proteome Project are alliances of research groups aimed at developing or improving proteomic tools to support specific biological or disease-related research areas. Here, we describe the activities and progress to date of the B/D working group focused on pro...

journal_title：Journal of proteome research

authors： Boersema PJ,Melnik A,Hazenberg BPC,Rezeli M,Marko-Varga G,Kamiie J,Portelius E,Blennow K,Zubarev RA,Polymenidou M,Picotti P

更新日期：2018-12-07 00:00:00

abstract：:Leukocytes play an important role in the progression of disease and leukocyte-derived proteins are associated with the pathogenesis of the disease. Leukocyte activation causes production of inflammatory mediators, over-expression of cell surface adhesion molecules, and an increase in migration and infiltration, phagoc...

journal_title：Journal of proteome research

authors： Wang X,Zhao H,Andersson R

更新日期：2004-09-01 00:00:00

abstract：:Chronic kidney disease (CKD) has emerged as a major public health problem worldwide. It frequently progresses to end-stage renal disease, which is related to very high cost and mortality. Novel biomarkers can provide insight into the novel mechanism, facilitate early detection, and monitor progression of CKD and its r...

journal_title：Journal of proteome research

authors： Zhang ZH,Chen H,Vaziri ND,Mao JR,Zhang L,Bai X,Zhao YY

更新日期：2016-10-07 00:00:00

abstract：:Hypoxia inducible factor (HIF)-2α protein expression in solid tumors promotes stem-like phenotype in cancer stem cells and increases tumorigenic potential in nonstem cancer cells. Recently, we have shown that HIF-1/2α gene expression is correlated to neuroblastoma (NB) poor survival and to undifferentiated tumor state...

journal_title：Journal of proteome research

authors： Cimmino F,Pezone L,Avitabile M,Persano L,Vitale M,Sassi M,Bresolin S,Serafin V,Zambrano N,Scaloni A,Basso G,Iolascon A,Capasso M

更新日期：2016-10-07 00:00:00

abstract：:Automated sequencing of unknowns in bottom-up proteomics makes the data produced susceptible to process control errors, which can be propagated into mistakes in analyte identification. Inclusion of an unintrusive internal standard, such as lysozyme, allows monitoring all phases of the proteomics process including samp...

journal_title：Journal of proteome research

authors： Riter LS,Hodge BD,Gooding KM,Julian RK Jr

更新日期：2005-01-01 00:00:00

abstract：:Lysine methylation plays important roles in structural and functional regulation of chromatin. Although trypsin is the most widely used protease in mass spectrometry-based proteomic analysis for lysine methylation substrates, the proteolytic activity of trypsin on dimethylated lysine residues remains an arguable issue...

journal_title：Journal of proteome research

authors： Chen M,Zhang M,Zhai L,Hu H,Liu P,Tan M

更新日期：2017-09-01 00:00:00

abstract：:"Omics" studies reported to date have dealt with either thoroughly characterized single species or poorly explored meta-microbial communities. However, these techniques are capable of producing highly informative data for the analysis of interactions between two organisms. We examined the bacterial interaction between...

journal_title：Journal of proteome research

authors： Nakanishi Y,Fukuda S,Chikayama E,Kimura Y,Ohno H,Kikuchi J

更新日期：2011-02-04 00:00:00

abstract：:Stroke remains a major public health problem worldwide; it causes severe disability and is associated with high mortality rates. However, early diagnosis of stroke is difficult, and no reliable biomarkers are currently established. In this study, mass-spectrometry-based metabolomics was utilized to characterize the me...

journal_title：Journal of proteome research

authors： Liu P,Li R,Antonov AA,Wang L,Li W,Hua Y,Guo H,Wang L,Liu P,Chen L,Tian Y,Xu F,Zhang Z,Zhu Y,Huang Y

更新日期：2017-02-03 00:00:00

abstract：:NMR ligand affinity screening is a powerful technique that is routinely used in drug discovery or functional genomics to directly detect protein-ligand binding events. Binding events can be identified by monitoring differences in the 1D (1)H NMR spectrum of a compound with and without protein. Although a single NMR sp...

journal_title：Journal of proteome research

authors： Stark JL,Eghbalnia HR,Lee W,Westler WM,Markley JL

更新日期：2016-04-01 00:00:00

abstract：:Peptide abundance estimation is generally the first step in protein quantification. In peptide abundance estimation, peptide overlapping and peak intensity variation are two challenges. The main objective of this paper is to estimate peptide abundance by taking advantage of peptide isotopic distribution and smoothness...

journal_title：Journal of proteome research

authors： Yang C,Yang C,Yu W

更新日期：2010-05-07 00:00:00

abstract：:In an attempt to find out the association of metabolic dysregulation with poor endometrial receptivity and pregnancy loss, serum metabonomic profiling of women with idiopathic recurrent spontaneous miscarriage (IRSM) is carried out and compared with fertile controls. (1)H nuclear magnetic resonance (NMR)-based metabon...

journal_title：Journal of proteome research

authors： Banerjee P,Dutta M,Srivastava S,Joshi M,Chakravarty B,Chaudhury K

更新日期：2014-06-06 00:00:00