Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes.

abstract：:Tear proteome profiling may generate useful information for the understanding of the interaction between an eye and its contacting objects, such as a contact lens or a lens implant. This is important for designing improved eye-care devices and maintaining the health of an eye. Proteome profiles of tear fluids may also...

journal_title：Journal of proteome research

authors： Li N,Wang N,Zheng J,Liu XM,Lever OW,Erickson PM,Li L

更新日期：2005-11-01 00:00:00

abstract：:The present study was undertaken to identify proteins interacting with PrP(C) that could provide new insights into its physiological functions and pathological role. Human PrP(C) was expressed in prion protein-deficient murine hippocampus (HpL3-4) neuronal cells. The PrP(C) along with its interacting proteins were aff...

journal_title：Journal of proteome research

authors： Zafar S,von Ahsen N,Oellerich M,Zerr I,Schulz-Schaeffer WJ,Armstrong VW,Asif AR

更新日期：2011-07-01 00:00:00

abstract：:Metal based chemotherapeutic drugs are widely used as an effective method to defeat various cancers. In this study, the mechanism of action of a novel therapeutic agent, [Pd(sac)(terpy)](sac)·4H2O (sac = saccharinate, and terpy = 2,2':6',2″-terpyridine) was studied. To better understand the proteomic changes in respon...

journal_title：Journal of proteome research

authors： Adiguzel Z,Baykal AT,Kacar O,Yilmaz VT,Ulukaya E,Acilan C

更新日期：2014-11-07 00:00:00

abstract：:14-3-3s are phosphoserine/phosphotreonine binding proteins that play pivotal roles as regulators of multiple cellular processes in eukaryotes. The flagellated protozoan parasite Giardia duodenalis, the causing agent of giardiasis, is a valuable simplified eukaryotic model. A single 14-3-3 isoform (g14-3-3) is expresse...

journal_title：Journal of proteome research

authors： Lalle M,Camerini S,Cecchetti S,Sayadi A,Crescenzi M,Pozio E

更新日期：2012-05-04 00:00:00

abstract：:Mass spectrometry (MS) is a widely used proteome analysis tool for biomedical science. In an MS-based bottom-up proteomic approach to protein identification, sequence database (DB) searching has been routinely used because of its simplicity and convenience. However, searching a sequence DB with multiple variable modif...

journal_title：Journal of proteome research

authors： Cho JY,Lee HJ,Jeong SK,Paik YK

更新日期：2017-12-01 00:00:00

abstract：:Rapid early triage and dose estimation is vital for limited medical resource allocation and treatment of a large number of the wounded after radiological accidents. Lipidomics has been utilized to delineate biofluid lipid signatures after irradiation. Here, high-coverage targeted lipidomics was employed to screen radi...

journal_title：Journal of proteome research

authors： Xi C,Zhao H,Lu X,Cai TJ,Li S,Liu KH,Tian M,Liu QJ

更新日期：2021-01-01 00:00:00

abstract：:Elevated atmospheric CO2 and nitrogen are major environmental factors affecting shoot growth. The objectives of this study are to determine the interactive effects of elevated CO2 and nitrogen on leaf growth in tall fescue ( Festuca arundinacea) and to identify major proteins and associated metabolic pathways underlyi...

journal_title：Journal of proteome research

authors： Yu J,Fan N,Li R,Zhuang L,Xu Q,Huang B

更新日期：2019-06-07 00:00:00

abstract：:Ribosomal proteins of the model gram-positive bacterium B. subtilis 168 were extensively characterized in a proteomic study. Mass spectra of the 52 proteins expected to be constitutive components of the 70S ribosome were recorded. Peptide MS/MS analysis with an average sequence coverage of 85% supported the identifica...

journal_title：Journal of proteome research

authors： Lauber MA,Running WE,Reilly JP

更新日期：2009-09-01 00:00:00

abstract：:Somatic embryo development (SED) in upland cotton shows low frequencies of embryo maturation and plantlet regeneration. Progress in increasing the regeneration rate has been limited. Here a global analysis of proteome dynamics between globular and cotyledonary embryos was performed using isobaric tags for relative and...

journal_title：Journal of proteome research

authors： Ge X,Zhang C,Wang Q,Yang Z,Wang Y,Zhang X,Wu Z,Hou Y,Wu J,Li F

更新日期：2015-01-02 00:00:00

abstract：:Although the legume-rhizobium symbiosis is a most-important biological process, there is a limited knowledge about the protein interaction network between host and symbiont. Using interolog- and domain-based approaches, we constructed an interspecies protein interactome containing 5115 protein-protein interactions bet...

journal_title：Journal of proteome research

authors： Zhang L,Liu JY,Gu H,Du Y,Zuo JF,Zhang Z,Zhang M,Li P,Dunwell JM,Cao Y,Zhang Z,Zhang YM

更新日期：2018-09-07 00:00:00

abstract：:As spectral library searching has received increasing attention for peptide identification, constructing good decoy spectra from the target spectra is the key to correctly estimating the false discovery rate in searching against the concatenated target-decoy spectral library. Several methods have been proposed to cons...

journal_title：Journal of proteome research

authors： Cheng CY,Tsai CF,Chen YJ,Sung TY,Hsu WL

更新日期：2013-05-03 00:00:00

abstract：:Pancreatic cancer is a formidable disease and early detection biomarkers are needed to make inroads into improving the outcomes in these patients. In this work, lectin antibody microarrays were utilized to detect unique glycosylation patterns of proteins from serum. Antibodies to four potential glycoprotein markers th...

journal_title：Journal of proteome research

authors： Li C,Simeone DM,Brenner DE,Anderson MA,Shedden KA,Ruffin MT,Lubman DM

更新日期：2009-02-01 00:00:00

abstract：:Starting in 2007, we have grown soybean (Glycine max [L.] Merr. variety Soniachna) and flax (Linum usitatissimum, L. variety Kyivskyi) in the radio-contaminated Chernobyl area and analyzed the seed proteomes. In the second-generation flax seeds, we detected a 12% increase in oil content. To characterize the bases for ...

journal_title：Journal of proteome research

authors： Klubicová K,Danchenko M,Skultety L,Berezhna VV,Rashydov NM,Hajduch M

更新日期：2013-11-01 00:00:00

abstract：:Large-scale phosphoproteomic analysis employing liquid chromatography-tandem mass spectrometry (LC-MS/MS) often requires a significant amount of manual manipulation of phosphopeptide datasets in the post-acquisition phase. To assist in this process, we have created software, PhosphoPIC (PhosphoPeptide Identification a...

journal_title：Journal of proteome research

authors： Hoffert JD,Wang G,Pisitkun T,Shen RF,Knepper MA

更新日期：2007-09-01 00:00:00

abstract：:An online nonenzymatic digestion method utilizing a microwave-heated flow cell and mild acid hydrolysis at aspartic acid (D) for rapid protein identification is described. This methodology, here termed microwave D-cleavage, was tested with proteins ranging in size from 5 kDa (insulin) to 67 kDa (bovine serum albumin) ...

journal_title：Journal of proteome research

authors： Hauser NJ,Basile F

更新日期：2008-03-01 00:00:00

abstract：:We aimed to evaluate neuroendocrine pulmonary tumors (NEPT) by a novel method involving map tree construction by comparing all of the protein spots. We performed a proteomics analysis to assess the similarities in protein expression between neuroendocrine pulmonary tumors (NEPT), including typical carcinoids (TC), aty...

journal_title：Journal of proteome research

authors： Cho NH,Koh ES,Lee DW,Kim H,Choi YP,Cho SH,Kim DS

更新日期：2006-03-01 00:00:00

abstract：:Coronary artery disease is one of the most frequent causes of morbidity and mortality worldwide. It is even more prevalent in patients with type 2 diabetes mellitus who suffer from obesity and increased accumulation of epicardial fat with a possible contributing role in the development of coronary artery disease. We p...

journal_title：Journal of proteome research

authors： Tomášová P,Čermáková M,Pelantová H,Vecka M,Kratochvílová H,Lipš M,Lindner J,Ivák P,Netuka I,Šedivá B,Haluzík M,Kuzma M

更新日期：2020-10-02 00:00:00

abstract：:Crohn's disease is an inflammatory disorder of the bowel, believed to arise from the dysregulation of intestinal mucosal immunity. The interleukin-10-deficient (IL10-/-) mouse, which develops intestinal inflammation in the presence of gut microflora, serves as a mouse model of Crohn's disease. Nontargeted urinary meta...

journal_title：Journal of proteome research

authors： Lin HM,Edmunds SI,Helsby NA,Ferguson LR,Rowan DD

更新日期：2009-04-01 00:00:00

abstract：:Although the "missing protein" is a temporary concept in C-HPP, the biological information for their "missing" could be an important clue in evolutionary studies. Here we classified missing-protein-encoding genes into two groups, the genes encoding PE2 proteins (with transcript evidence) and the genes encoding PE3/4 p...

journal_title：Journal of proteome research

authors： Xu A,Li G,Yang D,Wu S,Ouyang H,Xu P,He F

更新日期：2015-12-04 00:00:00

abstract：:The Biology/Disease-driven (B/D) working groups of the Human Proteome Project are alliances of research groups aimed at developing or improving proteomic tools to support specific biological or disease-related research areas. Here, we describe the activities and progress to date of the B/D working group focused on pro...

journal_title：Journal of proteome research

authors： Boersema PJ,Melnik A,Hazenberg BPC,Rezeli M,Marko-Varga G,Kamiie J,Portelius E,Blennow K,Zubarev RA,Polymenidou M,Picotti P

更新日期：2018-12-07 00:00:00

abstract：:One of the ultimate goals of systems biology research is to obtain a comprehensive understanding of the control mechanisms of complex cellular metabolisms. Metabolic Flux Analysis (MFA) is a important method for the quantitative estimation of intracellular metabolic flows through metabolic pathways and the elucidation...

journal_title：Journal of proteome research

authors： Toya Y,Kono N,Arakawa K,Tomita M

更新日期：2011-08-05 00:00:00

abstract：:Protein chemical cross-linking combined with mass spectrometry has become an important technique for the analysis of protein structure and protein-protein interactions. A variety of cross-linkers are well developed, but reliable, rapid, and user-friendly tools for large-scale analysis of cross-linked proteins are stil...

journal_title：Journal of proteome research

authors： Lu L,Millikin RJ,Solntsev SK,Rolfs Z,Scalf M,Shortreed MR,Smith LM

更新日期：2018-07-06 00:00:00

abstract：:Antibody reagents have been remained as a standard approach to characterize blood group (BG) antigens in clinic. The specificity and cross-reactivity of these BG antibodies are routine detected using the gel microcolumn assay (GMA). However, the GMA is neither specific nor sensitive, thus increasing the risk of improp...

journal_title：Journal of proteome research

authors： Yang L,Yu Y,Ma C,Wang H,Dai J,Duan H,Fu Z,Wu P,Wang D,Yu X

更新日期：2018-09-07 00:00:00

abstract：:Cellular functions are largely carried out by noncovalent protein complexes that may exist within the cell as stable modules or as assemblies of dynamically changing composition, whose formation and decomposition are triggered in response to extracellular stimuli. The protein constituents of complexes often exhibit po...

journal_title：Journal of proteome research

authors： Przybylski C,Jünger MA,Aubertin J,Radvanyi F,Aebersold R,Pflieger D

更新日期：2010-10-01 00:00:00

abstract：:There are new challenges for hazard and risk assessment in the chemical industry with regard to REACH legislation in Europe and related activities in the U.S. and Japan, which require the development of novel in vitro models for the molecular characterization of drug- or chemical-related effects replacing conventional...

journal_title：Journal of proteome research

authors： Groebe K,Hayess K,Klemm-Manns M,Schwall G,Wozny W,Steemans M,Peters AK,Sastri C,Jaeckel P,Stegmann W,Zengerling H,Schopf R,Poznanovic S,Stummann TC,Seiler A,Spielmann H,Schrattenholz A

更新日期：2010-11-05 00:00:00

abstract：:We analyzed the whole-cell protein content of gastrocnemius muscles from rats in different thyroid states. Twenty differentially expressed proteins were unambiguously identified. They were involved in substrates and energy metabolism, stress response, cell structure, and gene expression. This study represents the firs...

journal_title：Journal of proteome research

authors： Silvestri E,Burrone L,de Lange P,Lombardi A,Farina P,Chambery A,Parente A,Lanni A,Goglia F,Moreno M

更新日期：2007-08-01 00:00:00

abstract：:Dipetalogaster maxima is a blood-sucking Hemiptera that inhabits sylvatic areas in Mexico. It usually takes its blood meal from lizards, but following human population growth, it invaded suburban areas, feeding also on humans and domestic animals. Hematophagous insect salivary glands produce potent pharmacologic compo...

journal_title：Journal of proteome research

authors： Assumpção TC,Charneau S,Santiago PB,Francischetti IM,Meng Z,Araújo CN,Pham VM,Queiroz RM,de Castro CN,Ricart CA,Santana JM,Ribeiro JM

更新日期：2011-02-04 00:00:00

abstract：:Acute stress may trigger systemic biochemical and physiological changes in living organisms, leading to a rapid loss of homeostasis, which can be gradually reinstated by self-regulatory mechanisms and/or drug intervention strategy. However, such a sophisticated metabolic regulatory process has so far been poorly under...

journal_title：Journal of proteome research

authors： Wang X,Su M,Qiu Y,Ni Y,Zhao T,Zhou M,Zhao A,Yang S,Zhao L,Jia W

更新日期：2007-09-01 00:00:00

abstract：:The peptide toxins in the venoms of small invertebrates such as stinging ants have rarely been studied due to the limited amount of venom available per individual. We used a venomics strategy to identify the molecular diversity of the venom peptidome for the myrmicine ant Tetramorium bicarinatum. The methodology inclu...

journal_title：Journal of proteome research

authors： Touchard A,Téné N,Song PCT,Lefranc B,Leprince J,Treilhou M,Bonnafé E

更新日期：2018-10-05 00:00:00

abstract：:There is a legion of hypothetical proteins (HP) in prokaryotic and eukaryotic proteomes and the aim of this study was to describe HP in the perireticular nucleus (PN), a key structure in human brain development. Tissue from four PNs was homogenized and extracted proteins were run on two-dimensional gel electrophoresis...

journal_title：Journal of proteome research

authors： Hepner F,Myung JK,Ulfig N,Pollak A,Lubec G

更新日期：2005-11-01 00:00:00