We are what we eat: food safety and proteomics.


:In this review, we lead the reader through the evolution of proteomics application to the study of quality control in production processes of foods (including food of plant origin and transgenic plants in particular, but also meat, wine and beer, and milk) and food safety (screening for foodborne pathogens). These topics are attracting a great deal of attention, especially in recent years, when the international community has become increasingly aware of the central role of food quality and safety and their influence on the health of end-consumers. Early proteomics studies in the field of food research were mainly aimed at performing exploratory analyses of food (bovine, swine, chicken, or lamb meat, but also transgenic food such as genetically modified maize, for example) and beverages (wine), with the goal of improving the quality of the end-products. Recently, developments in the field of proteomics have also allowed the study of safety issues, as the technical advantages of sensitive techniques such as mass spectrometry have guaranteed a faster and improved individuation of food contaminating pathogens with unprecedented sensitivity and specificity.


J Proteome Res


D'Alessandro A,Zolla L




Has Abstract


2012-01-01 00:00:00












  • Large improvements in MS/MS-based peptide identification rates using a hybrid analysis.

    abstract::We report a hybrid search method combining database and spectral library searches that allows for a straightforward approach to characterizing the error rates from the combined data. Using these methods, we demonstrate significantly increased sensitivity and specificity in matching peptides to tandem mass spectra. The...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Cannon WR,Rawlins MM,Baxter DJ,Callister SJ,Lipton MS,Bryant DA

    更新日期:2011-05-06 00:00:00

  • Label-Free (XIC) Quantification of Venom Procoagulant and Neurotoxin Expression in Related Australian Elapid Snakes Gives Insight into Venom Toxicity Evolution.

    abstract::This study demonstrates a direct role of venom protein expression alteration in the evolution of snake venom toxicity. Avian skeletal muscle contractile response to exogenously administered acetylcholine is completely inhibited upon exposure to South Australian and largely preserved following exposure to Queensland ea...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Skejic J,Steer DL,Dunstan N,Hodgson WC

    更新日期:2015-11-06 00:00:00

  • A data-mining scheme for identifying peptide structural motifs responsible for different MS/MS fragmentation intensity patterns.

    abstract::Although tandem mass spectrometry (MS/MS) has become an integral part of proteomics, intensity patterns in MS/MS spectra are rarely weighted heavily in most widely used algorithms because they are not yet fully understood. Here a knowledge mining approach is demonstrated to discover fragmentation intensity patterns an...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Huang Y,Tseng GC,Yuan S,Pasa-Tolic L,Lipton MS,Smith RD,Wysocki VH

    更新日期:2008-01-01 00:00:00

  • Primary cell cultures arising from normal kidney and renal cell carcinoma retain the proteomic profile of corresponding tissues.

    abstract::Renal cell carcinoma (RCC) tissue is composed of a mixture of neoplastic and normal cells, which complicate proteome analysis. The aim of our study was to investigate whether it is feasible to establish primary cell cultures of RCC and of renal cortex maintaining the tissue phenotype along with a more homogeneous and ...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Perego RA,Bianchi C,Corizzato M,Eroini B,Torsello B,Valsecchi C,Di Fonzo A,Cordani N,Favini P,Ferrero S,Pitto M,Sarto C,Magni F,Rocco F,Mocarelli P

    更新日期:2005-09-01 00:00:00

  • Bradyrhizobium diazoefficiens USDA 110- Glycine max Interactome Provides Candidate Proteins Associated with Symbiosis.

    abstract::Although the legume-rhizobium symbiosis is a most-important biological process, there is a limited knowledge about the protein interaction network between host and symbiont. Using interolog- and domain-based approaches, we constructed an interspecies protein interactome containing 5115 protein-protein interactions bet...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Zhang L,Liu JY,Gu H,Du Y,Zuo JF,Zhang Z,Zhang M,Li P,Dunwell JM,Cao Y,Zhang Z,Zhang YM

    更新日期:2018-09-07 00:00:00

  • Analysis of secreted proteins for the study of bladder cancer cell aggressiveness.

    abstract::Secreted proteins play a key role in cell signaling, communication, and migration. We recently described the development of an aggressive variant (T24M) of the bladder cancer cell line T24. Using this cell line model, the objective of our work was the identification of secreted proteins involved in the acquisition of ...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Makridakis M,Roubelakis MG,Bitsika V,Dimuccio V,Samiotaki M,Kossida S,Panayotou G,Coleman J,Candiano G,Anagnou NP,Vlahou A

    更新日期:2010-06-04 00:00:00

  • Suppression of peptide sample losses in autosampler vials.

    abstract::Protein or peptide sample losses could accompany all steps of the proteomic analysis workflow. We focused on suppression of sample adsorptive losses during sample storage in autosampler vials. We examined suppression capabilities of six different sample injection solutions and seven types of autosampler vial surfaces ...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Stejskal K,Potěšil D,Zdráhal Z

    更新日期:2013-06-07 00:00:00

  • Interactome of the amyloid precursor protein APP in brain reveals a protein network involved in synaptic vesicle turnover and a close association with Synaptotagmin-1.

    abstract::Knowledge of the protein networks interacting with the amyloid precursor protein (APP) in vivo can shed light on the physiological function of APP. To date, most proteins interacting with the APP intracellular domain (AICD) have been identified by Yeast Two Hybrid screens which only detect direct interaction partners....

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Kohli BM,Pflieger D,Mueller LN,Carbonetti G,Aebersold R,Nitsch RM,Konietzko U

    更新日期:2012-08-03 00:00:00

  • Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose.

    abstract::We report the proteomic characterization and biological activities of the venom of the black-speckled palm pitviper, Bothriechis nigroviridis, a neotropical arboreal pitviper from Costa Rica. In marked contrast to other Bothriechis species investigated, the venom of B. nigroviridis does not possess detectable Zn(2+)-d...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Fernández J,Lomonte B,Sanz L,Angulo Y,Gutiérrez JM,Calvete JJ

    更新日期:2010-08-06 00:00:00

  • Purification and identification of O-GlcNAc-modified peptides using phosphate-based alkyne CLICK chemistry in combination with titanium dioxide chromatography and mass spectrometry.

    abstract::A selective method for the enrichment of O-GlcNAcylated peptides using a novel CLICK chemistry reagent is described. Peptides modified by O-GlcNAc were enzymatically labeled with N-azidoacetylgalactosamine. The azide was then reacted with a phospho-alkyne using CLICK chemistry and O-GlcNAcGalNAzPO(4)-containing peptid...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Parker BL,Gupta P,Cordwell SJ,Larsen MR,Palmisano G

    更新日期:2011-04-01 00:00:00

  • "Differential Visual Proteomics": Enabling the Proteome-Wide Comparison of Protein Structures of Single-Cells.

    abstract::Proteins are involved in all tasks of life, and their characterization is essential to understand the underlying mechanisms of biological processes. We present a method called "differential visual proteomics" geared to study proteome-wide structural changes of proteins and protein-complexes between a disturbed and an ...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Syntychaki A,Rima L,Schmidli C,Stohler T,Bieri A,Sütterlin R,Stahlberg H,Castaño-Díez D,Braun T

    更新日期:2019-09-06 00:00:00

  • Quality Control and Outlier Detection of Targeted Mass Spectrometry Data from Multiplex Protein Panels.

    abstract::Increased throughput as well as increased multiplexing of liquid chromatography coupled to selected reaction monitoring mass spectrometry (LC-SRM-MS) assays for protein quantification challenges routine data analysis. Despite the measurement of multiple transitions from multiple peptides, for clinical applications a s...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: van den Broek I,Mastali M,Mouapi K,Bystrom C,Bairey Merz CN,Van Eyk JE

    更新日期:2020-06-05 00:00:00

  • Disorder and sequence repeats in hub proteins and their implications for network evolution.

    abstract::Protein interaction networks display approximate scale-free topology, in which hub proteins that interact with a large number of other proteins determine the overall organization of the network. In this study, we aim to determine whether hubs are distinguishable from other networked proteins by specific sequence featu...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Dosztányi Z,Chen J,Dunker AK,Simon I,Tompa P

    更新日期:2006-11-01 00:00:00

  • Proteome analysis of membrane and cell wall associated proteins from Staphylococcus aureus.

    abstract::Pathogenesis of Staphylococcus aureus, an opportunistic human pathogen, is complex and involves many virulence factors including an array of surface proteins (adhesins) that promote bacterial interactions with extracellular matrix components. A better understanding of these interactions can be achieved by studying the...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Nandakumar R,Nandakumar MP,Marten MR,Ross JM

    更新日期:2005-03-01 00:00:00

  • Role of proteomics to differentiate between benign and potentially malignant pancreatic cysts.

    abstract::Pancreatic cystic neoplasms represent 10-15% of primary cystic masses of the pancreas. While pancreatic cysts are detected with an increasing frequency due to the use of advanced imaging modalities in clinical practice, the diagnosis of pancreatic cystic neoplasms remains unsatisfactory because available diagnostic te...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Cuoghi A,Farina A,Z'graggen K,Dumonceau JM,Tomasi A,Hochstrasser DF,Genevay M,Lescuyer P,Frossard JL

    更新日期:2011-05-06 00:00:00

  • Glycoproteomic analysis of glioblastoma stem cell differentiation.

    abstract::Cancer stem cells are responsible for tumor formation through self-renewal and differentiation into multiple cell types and thus represent a new therapeutic target for tumors. Glycoproteins play a critical role in determining the fates of stem cells such as self-renewal, proliferation, and differentiation. Here we app...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: He J,Liu Y,Zhu TS,Xie X,Costello MA,Talsma CE,Flack CG,Crowley JG,Dimeco F,Vescovi AL,Fan X,Lubman DM

    更新日期:2011-01-07 00:00:00

  • Proteomic and Glycoproteomic Profilings Reveal That Post-translational Modifications of Toxins Contribute to Venom Phenotype in Snakes.

    abstract::Snake venoms are biological weapon systems composed of secreted proteins and peptides that are used for immobilizing or killing prey. Although post-translational modifications are widely investigated because of their importance in many biological phenomena, we currently still have little understanding of how protein g...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Andrade-Silva D,Zelanis A,Kitano ES,Junqueira-de-Azevedo IL,Reis MS,Lopes AS,Serrano SM

    更新日期:2016-08-05 00:00:00

  • Mass spectrometry characterization of species-specific peptides from arginine kinase for the identification of commercially relevant shrimp species.

    abstract::The identification of commercial shrimp species is a relevant issue to ensure correct labeling, maintain consumer confidence and enhance the knowledge of the captured species, benefiting both, fisheries and manufacturers. A proteomic approach, based on 2DE, tryptic in-gel digestion, MALDI-TOF MS, and ESI-MS/MS analyse...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Ortea I,Cañas B,Gallardo JM

    更新日期:2009-11-01 00:00:00

  • The effects of rosiglitazone and high glucose on protein expression in endothelial cells.

    abstract::Rosiglitazone is a thiazolidinedione used to treat insulin resistance in diabetes. Although thiazolidinediones may also exert cardiovascular effects, contrasting results were reported. Favorable effects were shown for pioglitazone, whereas adverse reactions were suspected for rosiglitazone. Therefore, a reassessment o...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Millioni R,Puricelli L,Iori E,Arrigoni G,Tessari P

    更新日期:2010-01-01 00:00:00

  • Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid.

    abstract::Spontaneous preterm birth (SPTB) is a major contributor to perinatal morbidity and mortality. However, the diagnosis of preterm labor (PTL) that leads to preterm birth is difficult, and there is a pressing need for improved diagnosis. We utilized multidimensional liquid chromatography-tandem mass spectrometry (LC/LC-M...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Pereira L,Reddy AP,Jacob T,Thomas A,Schneider KA,Dasari S,Lapidus JA,Lu X,Rodland M,Roberts CT Jr,Gravett MG,Nagalla SR

    更新日期:2007-04-01 00:00:00

  • Protein profilings in mouse liver regeneration after partial hepatectomy using iTRAQ technology.

    abstract::Liver is unique in its capability to regenerate after an injury. Liver regeneration after a 2/3 partial hepatectomy served as a classical model and is adopted frequently to study the mechanism of liver regeneration. In the present study, semiquantitative analysis of protein expression in mouse liver regeneration follo...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Hsieh HC,Chen YT,Li JM,Chou TY,Chang MF,Huang SC,Tseng TL,Liu CC,Chen SF

    更新日期:2009-02-01 00:00:00

  • Global Analysis of Protein Lysine Succinylation Profiles and Their Overlap with Lysine Acetylation in the Marine Bacterium Vibrio parahemolyticus.

    abstract::Protein lysine acylation, including acetylation and succinylation, has been found to be a major post-translational modification (PTM) and is associated with the regulation of cellular processes that are widespread in bacteria. Vibrio parahemolyticus is a model marine bacterium that causes seafood-borne illness in huma...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Pan J,Chen R,Li C,Li W,Ye Z

    更新日期:2015-10-02 00:00:00

  • Development of an annotated library of neutral human milk oligosaccharides.

    abstract::Human milk oligosaccharides (HMOs) perform a number of functions including serving as prebiotics to stimulate the growth of beneficial intestinal bacteria, as receptor analogues to inhibit binding of pathogens, and as substances that promote postnatal brain development. There is further evidence that HMOs participate ...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Wu S,Tao N,German JB,Grimm R,Lebrilla CB

    更新日期:2010-08-06 00:00:00

  • Quantitative proteomic analysis of membrane proteins involved in astroglial differentiation of neural stem cells by SILAC labeling coupled with LC-MS/MS.

    abstract::Membrane proteins play a critical role in the process of neural stem cell self-renewal and differentiation. Here, we apply the SILAC (stable isotope labeling by amino acids in cell culture) approach to quantitatively compare the membrane proteome of the self-renewing and the astroglial differentiating cells. High-reso...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Cao R,Chen K,Song Q,Zang Y,Li J,Wang X,Chen P,Liang S

    更新日期:2012-02-03 00:00:00

  • Screening of Chemical Modifications in Human Skin Keratins by Mass Spectrometry-Based Proteomic Analysis via Noninvasive Sampling and On-Tape Digestion.

    abstract::Proteins are continuously exposed to diverse chemical stresses, and the resulting chemical modifications can provide significant information on biological events. Keratins are the main constituent of human skin and are the major target proteins of various chemical modifications. We have previously developed a mass spe...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Lee SH,Kawase J,Hiroshima Y,Oe T

    更新日期:2020-09-04 00:00:00

  • Ethylenediaminetetraacetic acid increases identification rate of phosphoproteomics in real biological samples.

    abstract::We have developed a novel approach to enhance phosphopeptide identification in liquid chromatography/mass spectrometry (LC/MS)-based phosphoproteomics. After enrichment of phosphopeptides with immobilized metal affinity chromatography (IMAC) and titanium dioxide (TiO(2)) microcolumns, samples were coinjected with ethy...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Nakamura T,Myint KT,Oda Y

    更新日期:2010-03-05 00:00:00

  • A Network Module for the Perseus Software for Computational Proteomics Facilitates Proteome Interaction Graph Analysis.

    abstract::Proteomics data analysis strongly benefits from not studying single proteins in isolation but taking their multivariate interdependence into account. We introduce PerseusNet, the new Perseus network module for the biological analysis of proteomics data. Proteomics is commonly used to generate networks, e.g., with affi...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Rudolph JD,Cox J

    更新日期:2019-05-03 00:00:00

  • Distinguishing between Spectral Clustering and Cluster Analysis of Mass Spectra.

    abstract::The term "spectral clustering" is sometimes used to refer to the clustering of mass spectrometry data. However, it also classically refers to a family of popular clustering algorithms. To avoid confusion, a more specific term could advantageously be coined. ...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Borges H,Guibert R,Permiakova O,Burger T

    更新日期:2019-01-04 00:00:00

  • Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line.

    abstract::Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identi...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Cimmino F,Spano D,Capasso M,Zambrano N,Russo R,Zollo M,Iolascon A

    更新日期:2007-07-01 00:00:00

  • Characterization of human tear proteome using multiple proteomic analysis techniques.

    abstract::Tear proteome profiling may generate useful information for the understanding of the interaction between an eye and its contacting objects, such as a contact lens or a lens implant. This is important for designing improved eye-care devices and maintaining the health of an eye. Proteome profiles of tear fluids may also...

    journal_title:Journal of proteome research

    pub_type: 杂志文章


    authors: Li N,Wang N,Zheng J,Liu XM,Lever OW,Erickson PM,Li L

    更新日期:2005-11-01 00:00:00