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Functionalized (poly(ɛ-caprolactone))₂-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers.

Abstract：

:Nicotinic acid was grafted on (poly(ɛ-caprolactone))(2)-poly(ethylene glycol) copolymers that were used for the preparation of nanoparticles with the objectives to monitor particle size and to optimize the drug loading capacity as well as the release profile of the particles. Increasing amounts of grafting nicotinic acid increased the particle size as a result of an enhanced hydrophobicity of the copolymer. Ibuprofen and indomethacin with two different molecular characteristics were selected as model drugs to be bound to the nanoparticles. The presence of grafting nicotinic acid enhanced the loading capacity for both drugs compared to the nanoparticles without nicotinic acid. However, no correlation between amount of grafting nicotinic acid and loading capacity was observed. The release characteristic of both drugs was fitted to the Higuchi model indicating Fickian diffusion. The release characteristic of indomethacin mainly depended on the crystalline property of the copolymer whereas that of ibuprofen was additionally influenced by the hydrogen bonding between drug and grafted copolymer.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Suksiriworapong J,Sripha K,Kreuter J,Junyaprasert VB

doi

10.1016/j.ijpharm.2011.11.033

subject

Has Abstract

pub_date

2012-02-28 00:00:00

pages

562-70

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(11)01074-X

journal_volume

423

pub_type

杂志文章

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