Abstract:
OBJECTIVE:Digital ulcers represent one of the most frequent complications of systemic sclerosis (SSc; scleroderma); they are very painful, scarcely responsive to treatment, and often responsible for marked limitations on daily activities, including patient self-care. Infectious complications may severely compromise the outcome of skin lesions in a significant percentage of patients. Numerous pathogens of different origin may be involved, including bacteria from patient endogenous flora. Here we evaluated the possible involvement of fecal pathogens in scleroderma digital ulcers. METHODS:Among a series of 82 SSc patients with digital ulcers, we retrospectively analyzed 42 subjects with clinical signs of local bacterial infection. All digital ulcers with suspected infection have been investigated by microbiologic examinations. RESULTS:Bacterial infection was confirmed in all 42 patients investigated; in particular, Staphylococcus aureus were the most frequently found (50%). Interestingly, 11 (26%) of 42 patients showed digital ulcers infected with intestinal bacteria; specifically, 7 patients were positive for Escherichia coli and 4 for Enterococcus faecalis. Diffuse cutaneous SSc patients were more numerous in this subgroup versus the other 31 patients (Fisher's P = 0.011). CONCLUSION:A number of effective measures involving health care personnel and hospital environment are essential in the management of digital ulcers and prevention of infectious complications. In addition, the prevalence of fecal pathogens in one-quarter of cases, never reported previously, suggests an important role of a patient's self-care limitations, mainly during intercurrent home medications. Consequently, methodical education on hand hygiene of both patients and relatives, frequently involved in ulcer medications, is mandatory to avoid such deleterious complications.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Giuggioli D,Manfredi A,Colaci M,Lumetti F,Ferri Cdoi
10.1002/acr.20673subject
Has Abstractpub_date
2012-02-01 00:00:00pages
295-7issue
2eissn
2151-464Xissn
2151-4658journal_volume
64pub_type
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-11-30 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21760
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abstract:OBJECTIVE:The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle-aged individuals with hip or knee pain. Radiographs were assigned Kellgren & Lawrence (KL) scores under different conditions at each follow-up visit for 10 years. We aimed to describe and consolidate each scoring approach, then illustrate implicatio...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2021-01-15 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20415
更新日期:2011-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/acr.23192
更新日期:2017-11-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2010-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21820
更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22650
更新日期:2016-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21677
更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/acr.23434
更新日期:2018-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/acr.23009
更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章,实务指引
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更新日期:2019-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22991
更新日期:2017-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23876
更新日期:2020-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-11-01 00:00:00
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pub_type: 共识发展会议,杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24534
更新日期:2020-12-08 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析,多中心研究
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更新日期:2010-10-01 00:00:00