Abstract:
OBJECTIVE:To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE activity (Systemic Lupus Activity Questionnaire [SLAQ]) and organ damage (self-administered Brief Index of Lupus Damage [SA-BILD]). We investigated the association of LIT scores with general HRQoL using the Short Form 12 (SF-12). METHODS:Correlation, multivariable regression, and longitudinal analyses using general linear modeling with fixed effects were performed to investigate the association between the LIT and patient-reported disease activity (SLAQ); patient-reported disease damage (SA-BILD); mental health (mental component summary [MCS] of the SF-12); and physical health (physical component summary [PCS] of the SF-12). Demographic trends related to the LIT were also assessed using cross-sectional analysis. RESULTS:The LIT was significantly associated with disease activity (SLAQ), organ damage (SA-BILD), MCS scores, and PCS scores in both adjusted and unadjusted regression analysis (P < 0.0001). Longitudinal analysis demonstrated a significant association between the LIT and disease activity (SLAQ), MCS scores, and PCS scores (P < 0.0001), but not organ damage (SA-BILD). CONCLUSION:The LIT is a simple, patient-centered tool that can be used to assess HRQoL in patients with SLE. This study provides external validity of the LIT in a population-based cohort with a large number of African American patients with a relatively high disease burden.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Brandt JE,Drenkard C,Kan H,Bao G,Dunlop-Thomas C,Pobiner B,Chang DJ,Jolly M,Lim SSdoi
10.1002/acr.23009subject
Has Abstractpub_date
2017-06-01 00:00:00pages
842-848issue
6eissn
2151-464Xissn
2151-4658journal_volume
69pub_type
杂志文章abstract:OBJECTIVE:Although it is common for rheumatologists to initiate biologic agents after failure of methotrexate monotherapy in rheumatoid arthritis (RA), ample data support the initial use of combinations of conventional therapies in this clinical scenario. Our study explores the durability of triple therapy (methotrexat...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Arthritis care & research
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doi:10.1002/acr.23434
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更新日期:2011-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00