Abstract:
OBJECTIVE:To characterize patterns of biologics use and discontinuation before and during pregnancy in women with autoimmune diseases in British Columbia, Canada. METHODS:Women with ≥1 autoimmune diseases, as identified by International Classification of Diseases Ninth/Tenth Revision codes, who had pregnancies ending in deliveries between January 1, 2002, and December 31, 2012, and had ≥1 prescription for a biologic drug 1 year before pregnancy or during pregnancy, were included. Secular trends, patterns of biologics use, and risk of biologics discontinuation before and during pregnancy were examined. Associations between drug discontinuations and various factors were investigated using multilevel logistic regression models, fitted with binomial generalized estimating equations. RESULTS:Of 6,218 women (8,431 pregnancies) with autoimmune diseases, 131 women (144 pregnancies) were exposed to a biologic before or during pregnancy. The use of biologics in this cohort increased from 0% in 2002 to 5.7% by 2012 (P < 0.001). Within the first trimester of pregnancy, 31% of women (34/110) discontinued their biologic treatment, and 38% (30/79) discontinued use in the second trimester, while 98% of those receiving treatment in the second trimester (50/51) continued treatment in the third trimester. Women with rheumatoid arthritis had three times higher odds (odds ratio 3.40 [95% confidence interval 1.33-8.71]) of discontinuing biologics during pregnancy, compared to those with inflammatory bowel disease. CONCLUSION:Given the increased use of biologics and high odds of discontinuation during pregnancy in certain populations, more research is needed to improve our understanding of the risks and benefits of biologics for fetal and maternal health.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Tsao NW,Lynd LD,Sadatsafavi M,Hanley G,De Vera MAdoi
10.1002/acr.23434subject
Has Abstractpub_date
2018-07-01 00:00:00pages
979-986issue
7eissn
2151-464Xissn
2151-4658journal_volume
70pub_type
杂志文章abstract:OBJECTIVE:To clarify sex differences in early axial spondyloarthritis (SpA). METHODS:In total, 475 patients included in the Devenir des Spondylarthropathies Indifférenciées Récentes (Outcome of Recent Undifferentiated Spondylarthropathies) cohort, a prospective multicenter French cohort of patients with early inflamma...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22001
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle-aged individuals with hip or knee pain. Radiographs were assigned Kellgren & Lawrence (KL) scores under different conditions at each follow-up visit for 10 years. We aimed to describe and consolidate each scoring approach, then illustrate implicatio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24563
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVE:Two surveys were conducted with patients with rheumatologic diseases to evaluate perceptions of different routes of administration (intravenous [IV] or subcutaneous [SC]) for biologic therapy. METHODS:In Survey I, patient preferences toward biologic treatment were evaluated at a rheumatology practice in Buff...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23758
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS:Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and methodologists generated key clinical questions to be addressed ...
journal_title:Arthritis care & research
pub_type: 杂志文章,实务指引
doi:10.1002/acr.23871
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To determine the additional effects of transcutaneous electrical nerve stimulation (TENS) for knee osteoarthritis (OA) when combined with a group education and exercise program (knee group). METHODS:The study was a randomized, sham-controlled clinical trial. Patients referred for physiotherapy with suspected...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22147
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oxidative stress is increased in patients with rheumatoid arthritis (RA) due to increased inflammation and contributes to the pathogenesis of atherosclerosis. METHODS:The independent association between urinary F₂-isoprostane excretion, a measure of oxidative stress, and RA was te...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20237
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether people who report both arthritis and back problems report poorer health outcomes than those who have either condition alone. METHODS:We performed an analysis of the 2005 Canadian Community Health Survey (n = 126,049, age ≥15 years). Respondents were asked about long-term chronic health...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20595
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine if baseline 3-dimensional (3-D) biomechanical gait patterns differed between those patients with moderate knee osteoarthritis (OA) who progressed to total knee arthroplasty (TKA) and those that did not, and whether these differences had predictive value. METHODS:Fifty-four patients with knee OA ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22564
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Studies have implicated foot posture and foot function as risk factors for lower extremity pain. Empirical population-based evidence for this assertion is lacking; therefore, the purpose of this study was to evaluate cross-sectional associations of foot posture and foot function to lower extremity joint pain ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22049
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Pulmonary arterial hypertension (PAH) is a rare but serious complication of systemic lupus erythematosus (SLE). Chronic hypoxia is known to cause PAH resulting from pulmonary vascular remodeling. We investigated the association between anemic hypoxia and PAH in SLE patients. METHODS:Systolic pulmonary artery...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22630
更新日期:2015-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23255
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To examine temporal trends in mortality rates in a large nationwide cohort of patients with end-stage renal disease (ESRD) due to granulomatosis with polyangiitis (Wegener's) (GPA-ESRD). METHODS:We identified cases of GPA-ESRD reported in the US Renal Data System between 1995 and 2014, using coding by nephro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23521
更新日期:2018-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1002/acr.20250
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To determine whether calcinosis and acro-osteolysis are related to specific nailfold videocapillaroscopy (NVC) features in patients with systemic sclerosis (SSc; scleroderma). METHODS:NVC and bilateral hand radiographs were systematically performed in 155 consecutively recruited patients with SSc during a 24...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22672
更新日期:2016-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24525
更新日期:2020-11-30 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24507
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVE:To describe the perception of the current role of systemic glucocorticoids in the management of rheumatoid arthritis (RA) by examining their importance and the current level of evidence in recent guidelines, and to identify open questions to be addressed in future guidelines and research projects. METHODS:We...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.23185
更新日期:2017-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23017
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Telemedicine is increasingly being offered to patients for rheumatology care, but few studies have examined factors associated with telemedicine use or outcomes of telemedicine in rheumatology. The objective of this analysis was to determine factors associated with the use of video telemedicine when offered a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24049
更新日期:2020-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24526
更新日期:2020-12-04 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23750
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:A treat-to-target (TTT) strategy is recommended in rheumatoid arthritis (RA). However, health care providers' adherence to TTT in clinical practice remains unclear. We examined adherence to TTT in RA at US rheumatology sites. METHODS:We used baseline information from the randomized controlled Treat-to-Target...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23343
更新日期:2018-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24329
更新日期:2020-05-31 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23101
更新日期:2017-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.24137
更新日期:2020-01-07 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24141
更新日期:2020-01-21 00:00:00
abstract:OBJECTIVE:To explore patients' knowledge and beliefs about osteoarthritis (OA) and OA risk following anterior cruciate ligament (ACL) injury, to explore the extent to which information about these risks is provided by health professionals, and to examine associations among participant characteristics, knowledge, and ri...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22794
更新日期:2016-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20125
更新日期:2010-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22380
更新日期:2015-01-01 00:00:00