Abstract:
OBJECTIVE:Localized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients. METHODS:We analyzed longitudinal data from a single-center cohort of juvenile localized scleroderma patients, using hierarchical generalized linear modeling (HGLM) to identify predictors of QoL impact. HGLM is useful for nested data and allows for evaluation of both time-variant and time-invariant predictors. RESULTS:The number of extracutaneous manifestations (ECMs; e.g., joint contracture and hemifacial atrophy) and female sex predicted negative QoL impact, defined as a Children's Dermatology Life Quality Index score >1 (P = 0.019 for ECMs and P = 0.002 for female sex). As the time since the initial visit increased, the odds of reporting a negative QoL impact decreased (P < 0.001). CONCLUSION:Our results suggest that ECMs, sex, and time since initial visit are more predictive of QoL impact in localized scleroderma than cutaneous features. Further study is required to determine which ECMs have the most impact on QoL, which factors underlie sex differences in QoL in localized scleroderma, and why increasing the time since the initial visit appears to be protective. An improved understanding of predictors of QoL impact may allow for the identification of patients at risk of poorer outcomes and for the tailoring of treatment and psychosocial support.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Ardalan K,Zigler CK,Torok KSdoi
10.1002/acr.23101subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1082-1087issue
7eissn
2151-464Xissn
2151-4658journal_volume
69pub_type
杂志文章abstract:OBJECTIVE:The availability of reliable estimates of the burden of musculoskeletal disease is of considerable importance for policymakers. METHODS:This study uses data from the 14,507 participants of the European Health Interview Survey conducted in Austria in 2006/2007 to calculate estimates of the prevalence of osteo...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) predominantly affects women. Clinical phenotype and outcomes in SLE may vary by sex and are further complicated by unique concerns that are dependent upon sex-defined roles. We aimed to describe sex differences in disease-specific quality of life (QoL) assessment scores usin...
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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更新日期:2018-11-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21846
更新日期:2013-04-01 00:00:00
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更新日期:2012-06-01 00:00:00
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更新日期:2017-08-01 00:00:00
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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更新日期:2011-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-10-01 00:00:00
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更新日期:2016-08-01 00:00:00
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