Abstract:
OBJECTIVE:To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM). METHODS:We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi-square or Fisher's exact tests and used univariate and multivariate logistic regression models to assess the association between ulcers and clinical features such as malignancy, interstitial lung disease (ILD), and amyopathic disease. RESULTS:Forty-three patients (28%) had cutaneous ulcers. Nearly half the patients had ulcers present in more than 1 location: 24 (56%) had ulcers over the extensor surfaces of joints, 18 (42%) at the digital pulp or periungual areas, and 25 (58%) had ulcers located elsewhere. In univariate analysis ulcers were associated with Asian race, but not with other clinical and demographic features, including malignancy or ILD. In multivariate analysis ulcers were significantly associated with anti-melanoma differentiation gene 5 (anti-MDA5) antibodies (odds ratio 10.14, 95% confidence interval 1.95-52.78; P = 0.0059) and this was greatest for ulcers located at the digital pulp. In patients with cutaneous ulcers, ILD risk was specifically increased only in patients with anti-MDA5-positive antibodies. CONCLUSION:We confirmed the strong association between anti-MDA5 antibodies and cutaneous ulcers, with the novel finding that the association of cutaneous ulcers with ILD depends upon the presence of anti-MDA5 antibodies. DM patients who display this cutaneous phenotype should undergo appropriate evaluation for ILD.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Narang NS,Casciola-Rosen L,Li S,Chung L,Fiorentino DFdoi
10.1002/acr.22498subject
Has Abstractpub_date
2015-05-01 00:00:00pages
667-72issue
5eissn
2151-464Xissn
2151-4658journal_volume
67pub_type
杂志文章abstract:OBJECTIVE:To assess the epidemiology, clinical features, and outcomes of systemic lupus erythematosus (SLE) in the predominantly African Caribbean population of Barbados. METHODS:A national registry of all patients diagnosed with SLE was established in 2007. Complete case ascertainment was facilitated by collaboration...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21656
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Digital ulcers represent one of the most frequent complications of systemic sclerosis (SSc; scleroderma); they are very painful, scarcely responsive to treatment, and often responsible for marked limitations on daily activities, including patient self-care. Infectious complications may severely compromise the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20673
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:The role of cardiovascular disease (CVD) risk factors in psoriatic arthritis (PsA) is poorly understood. We examined the prevalence of CVD risk factors at initial onset of PsA and compared the observed incidence of CVD events with that predicted by the Framingham Risk Score (FRS) to determine its applicabilit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22536
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:A lack of agreement between clinician and patient priorities can impact the clinician-patient relationship, treatment concordance, and potential health outcomes. Studies have suggested that patients with osteoarthritis (OA) may prioritize comorbidities over their OA, but as yet no explicit systematic explorat...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21897
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Two surveys were conducted with patients with rheumatologic diseases to evaluate perceptions of different routes of administration (intravenous [IV] or subcutaneous [SC]) for biologic therapy. METHODS:In Survey I, patient preferences toward biologic treatment were evaluated at a rheumatology practice in Buff...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23758
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To clarify sex differences in early axial spondyloarthritis (SpA). METHODS:In total, 475 patients included in the Devenir des Spondylarthropathies Indifférenciées Récentes (Outcome of Recent Undifferentiated Spondylarthropathies) cohort, a prospective multicenter French cohort of patients with early inflamma...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22001
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA). METHODS:This was an assessor-blinded, 3-arm randomized controlled trial in 22...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22744
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The US national prevalence of spondylarthritis (SpA) was estimated for 2 published sets of classification criteria: the Amor criteria and the European Spondylarthropathy Study Group (ESSG) criteria. These 2 SpA criteria sets have been the most widely utilized in previous population-based studies of SpA. METH...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21621
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To explore patients' knowledge and beliefs about osteoarthritis (OA) and OA risk following anterior cruciate ligament (ACL) injury, to explore the extent to which information about these risks is provided by health professionals, and to examine associations among participant characteristics, knowledge, and ri...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22794
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To determine if mortality is increased among patients diagnosed as having fibromyalgia. METHODS:We studied 8,186 fibromyalgia patients seen between 1974 and 2009 in 3 settings: all fibromyalgia patients in a clinical practice, patients participating in the US National Data Bank for Rheumatic Diseases (NDB), ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20301
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To compare the quality of care received by patients with systemic lupus erythematosus (SLE) in 2 settings within the academic institution (a dedicated lupus clinic and a general rheumatology clinic) using validated SLE quality measures. METHODS:One hundred fifty consenting, consecutive SLE patients receiving...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23569
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:In early rheumatoid arthritis (RA), treating to a target is more effective than routine care (RC). Our aim was to determine if treating to a target has better outcomes than RC in established active RA. METHODS:We used a real-world, 18-month cluster-randomized trial in established active RA patients treated w...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22010
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To study low blood hemoglobin concentrations as a predictor of radiographic damage progression in patients with rheumatoid arthritis (RA). METHODS:Post hoc analyses were performed in patients from the PREMIER trial with early RA undergoing 2 years of adalimumab (ADA), methotrexate (MTX), or ADA + MTX combina...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23427
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To determine whether perceptions of clinical manifestations (fatigue, pain, and physical limitation) of rheumatoid arthritis (RA) differ between spouses and their partners with RA, and to determine whether the differences are associated with the perception of beneficial and problematic spousal social support....
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20330
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between exposure to oral contraceptives (OCs) and clinical outcomes in an early arthritis cohort. METHODS:Female patients with early inflammatory arthritis, ages 18-60 years, who were enrolled in an early arthritis cohort and had no exposure to hormone replacement were studied (n ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22667
更新日期:2016-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23787
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23102
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To describe long-term physical functioning and its association with somatic comorbidity and comorbid depression in patients with established rheumatoid arthritis (RA). METHODS:Longitudinal data over a period of 11 years were collected from 882 patients with RA at study inclusion. Patient-reported outcomes we...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21950
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Ankle-foot problems have a considerable impact on daily functioning in patients with hypermobile Ehlers-Danlos syndrome and Hypermobility Spectrum Disorder (hEDS/HSD). Therefore, the objective of this study is to identify alterations in multi-segment ankle and foot kinematics during gait and assessing foot fu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24526
更新日期:2020-12-04 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations of diffuse idiopathic skeletal hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS:DISH and kyphosis were assessed in 1,500 men from the Osteoporotic Fractures in Men (MrOS) study and in 1,267 women from the Study of Osteoporotic Fr...
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pub_type: 杂志文章
doi:10.1002/acr.23115
更新日期:2017-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20200
更新日期:2010-09-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22396
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:In a pilot study, our group showed that an internet-based self-management program improves self-efficacy in systemic sclerosis (SSc). The objective of the current study was to compare an internet-based self-management program to a patient-focused educational book developed to assess measures of self-efficacy ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23595
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To review the performance characteristics of the instruments most commonly used to measure clinical outcomes in juvenile idiopathic arthritis (JIA), including global assessments, articular indices, functional/disability assessments, and quality of life measures. METHODS:As part of an Agency for Healthcare Re...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20667
更新日期:2012-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22304
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To investigate physical therapists' knowledge, beliefs, and current practices around falls prevention in osteoarthritis (OA) care. METHODS:Currently registered, practicing Australian physical therapists who care for patients with hip and/or knee OA were invited to participate in this cross-sectional study. A...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23996
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Hydroxychloroquine (HCQ) has been associated with improved survival among SLE patients from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. METHODS:We conducted a nested case-control study within an incide...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24255
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease (CVD) risk. Pregnancy morbidities, including preeclampsia, and CVD are common in systemic lupus erythematosus (SLE). Possible connections are important to explore. In a population-based cohort, we investigated whether HDP is associated...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24160
更新日期:2020-01-31 00:00:00
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journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.22974
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To understand the impact of ankylosing spondylitis (AS) on work disability (WD) over 12 years compared with the general population, and explore factors predicting adverse work outcome, defined as new partial WD or reduction in working hours. METHODS:Source of data was the Outcome Assessments in Ankylosing Sp...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22730
更新日期:2016-04-01 00:00:00