Abstract:
BACKGROUND:Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease (CVD) risk. Pregnancy morbidities, including preeclampsia, and CVD are common in systemic lupus erythematosus (SLE). Possible connections are important to explore. In a population-based cohort, we investigated whether HDP is associated with a higher risk of cardiovascular outcomes separately in SLE and non-SLE to examine the role of SLE. METHODS:We identified first singleton births in the Medical Birth Register (1987-2012) among mothers with SLE and a large general population comparison group. Discharge diagnoses for HDP, cardiovascular outcomes, and hypertension in the Patient Register were identified using ICD codes. We estimated adjusted hazard ratios and 95% confidence intervals (HR, 95% CI) of the association between HDP and outcomes, in separate models in women with and without SLE. We then evaluated additive and multiplicative effect modification using relative excess risk due to interaction and Cox models jointly accounting for SLE and HDP, respectively. Mediation analysis estimated the proportion of the association between SLE and outcome explained by HDP. RESULTS:HDP were more common in SLE pregnancies (20% vs 7%). In SLE, HDP were associated with a two-fold higher rate of cardiovascular outcomes and three-fold higher rate of incident hypertension. HDP mediated 20% of the latter association. In women without SLE, HDP was associated with higher hypertension incidence later in life. CONCLUSION:In women with and without SLE, HDP were associated with a three-fold higher rate of hypertension. In SLE, women with HDP developed cardiovascular outcomes twice as often as women without HDP.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Simard JF,Rossides M,Arkema EV,Svenungsson E,Wikström AK,Mittleman MA,Salmon JEdoi
10.1002/acr.24160subject
Has Abstractpub_date
2020-01-31 00:00:00eissn
2151-464Xissn
2151-4658pub_type
杂志文章abstract:OBJECTIVE:Knowledge about systemic lupus erythematosus (SLE) outcomes among US Asians is lacking. We examined SLE disease activity, severity, and damage among Asians of primarily Chinese and Filipino descent in a multiethnic cohort. METHODS:California Lupus Epidemiology Study (CLUES, n=328) data were analyzed. Data we...
journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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journal_title:Arthritis care & research
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-09-01 00:00:00
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2013-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
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更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00