Abstract:
OBJECTIVE:To examine trends in glucocorticoid (GC) use and dosing among patients diagnosed with rheumatoid arthritis (RA) over time. METHODS:A population-based inception cohort of RA patients diagnosed during 1980-2007 was followed longitudinally through their medical records until death, migration, or December 31, 2008. GC start and stop dates were collected, along with doses in prednisone equivalents. RESULTS:The study population comprised 349 patients (68% women) diagnosed in 1980-1994 and 464 (69% women) diagnosed in 1995-2007, with a median followup of 15.3 and 5.7 years, respectively. A higher proportion of patients started GCs in their first year of disease in 1995-2007 (68% versus 36%; P < 0.001), but the starting dose (mean 8.7 versus 10.3 mg; P = 0.08) and cumulative dose in the first year of use (mean 1.8g [mean daily dose 4.9 mg] versus 2.1 gm [mean daily dose 5.8 mg]; P = 0.48) were not different. A higher proportion also discontinued GCs in their first year of disease in the 1995-2007 cohort (P < 0.001). These differences in GC initiation and discontinuation persisted throughout followup. Prevalence of GC use was higher in the 1995-2007 cohort for the first 3 years of disease. CONCLUSION:More patients are starting GCs early in their disease course now compared to previously, which is consistent with established treatment guidelines. A higher proportion are also discontinuing GCs, but the proportion of patients taking GCs at any given point of disease during the first 4 years is higher now than previously. Despite early addition of a disease-modifying antirheumatic drug, some patients may not be able to discontinue GCs over the long term.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Makol A,Davis JM 3rd,Crowson CS,Therneau TM,Gabriel SE,Matteson ELdoi
10.1002/acr.22365subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1482-8issue
10eissn
2151-464Xissn
2151-4658journal_volume
66pub_type
杂志文章abstract:OBJECTIVE:To determine if low-risk elderly patients with rheumatoid arthritis (RA) who screen positive for latent tuberculosis (TB) infection prior to anti–tumor necrosis factor (anti-TNF) therapy should be given isoniazid (INH). METHODS:A Markov model was developed. The base case was a patient age 65 years with RA st...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To determine whether perceptions of clinical manifestations (fatigue, pain, and physical limitation) of rheumatoid arthritis (RA) differ between spouses and their partners with RA, and to determine whether the differences are associated with the perception of beneficial and problematic spousal social support....
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20330
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20442
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To assess health-related quality of life (HRQOL) in abatacept-treated children/adolescents with juvenile idiopathic arthritis (JIA). METHODS:In this phase III, double-blind, placebo-controlled trial, subjects with active polyarticular course JIA and an inadequate response/intolerance to ≥1 disease-modifying ...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/acr.20283
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Cognitive function may change over time in patients with SLE, and cognitive function trajectories have not well been studied. We aim to: 1) identify cognitive function trajectories in SLE and describe it with depressive symptoms trajectories and 2) identify baseline factors associated with class membership i...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24349
更新日期:2020-06-11 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20517
更新日期:2011-09-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-12-08 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22082
更新日期:2013-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24370
更新日期:2020-07-03 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24329
更新日期:2020-05-31 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22228
更新日期:2014-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 社论
doi:10.1002/acr.24198
更新日期:2020-04-05 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23887
更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-10-12 00:00:00
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pub_type: 杂志文章
doi:10.1002/acr.22728
更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22609
更新日期:2015-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20118
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/acr.24141
更新日期:2020-01-21 00:00:00
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pub_type: 杂志文章
doi:10.1002/acr.22559
更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) has been linked to functional disability and increased risk of falls, but mechanisms underpinning functional disability are unclear. This study investigated functional performance, muscle strength, and plantar pressures in adults with mild, moderate, and severe HV compared to controls, whil...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22380
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To identify the principal determinants of health-related quality of life (HRQOL) impairment in patients with active primary Sjögren's syndrome (SS) participating in a large therapeutic trial, Tolerance and Efficacy of Rituximab in Primary Sjögren's Syndrome (TEARS). METHODS:At the inclusion visit for the TEA...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.22974
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We compared patient-reported outcomes (PROs) in patients with RA treated with tofacitinib or placebo in combination with conventional disease-modifying antirheumatic drugs (DMARDs). METHODS:In a 12-month, phase III ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23004
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23255
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The present study attempted to fill a research gap by performing the first dimensionality analysis of the Revised Fibromyalgia Impact Questionnaire (FIQR) using exploratory and confirmatory techniques. A second objective was to report on the reliability and construct validity of the FIQR in Spanish patients. ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22034
更新日期:2013-10-01 00:00:00