Abstract:
OBJECTIVE:To determine if low-risk elderly patients with rheumatoid arthritis (RA) who screen positive for latent tuberculosis (TB) infection prior to anti–tumor necrosis factor (anti-TNF) therapy should be given isoniazid (INH). METHODS:A Markov model was developed. The base case was a patient age 65 years with RA starting anti-TNF therapy with a positive tuberculin skin test (TST) finding of 5–9 mm, who was born in a country with low TB prevalence and had no other TB risk factors. The decision was 9 months of INH or not. The primary outcome was quality-adjusted life expectancy. Multiple sensitivity analyses were performed. RESULTS:No prophylaxis was favored, with a gain of 1.1 quality-adjusted life days, but the decision was sensitive to several variables. Prophylaxis was favored for patients ages <61 years, if the relative risk (RR) of TB reactivation with RA alone was >2.5, if the RR with anti-TNF therapy was >5.8, or if the utility associated with INH therapy was >0.98. Prophylaxis was also preferred for patients with a TST result >10 mm and for patients from higher risk countries. If 6 months of INH or 4 months of rifampin were used, prophylaxis was preferred, providing that therapy reduced the risk of TB reactivation by >47% and >27%, respectively. CONCLUSION:Withholding prophylaxis prior to anti-TNF therapy may be reasonable for low-risk elderly RA patients with a TST finding of 5–9 mm, although the decision is sensitive to patient preferences. For patients age <61 years from a higher risk country, or with a TST finding >10 mm, prophylaxis is preferred.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Hazlewood GS,Naimark D,Gardam M,Bykerk V,Bombardier Cdoi
10.1002/acr.22063subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1722-31issue
11eissn
2151-464Xissn
2151-4658journal_volume
65pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To determine the extent to which demographic and geographic disparities exist in the use of post-acute rehabilitation care (PARC) for joint replacement. METHODS:We conducted a cross-sectional analysis of 2 years (2005 and 2006) of population-based hospital discharge data from 392 hospitals in 4 states (Arizo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20477
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To determine the influence of socioeconomic factors on disease activity in a Latin American (LA) early rheumatoid arthritis (RA) multinational inception cohort at baseline. METHODS:Clinical evaluation, ethnicity, socioeconomic status (SES), 4-variable Disease Activity Score in 28 joints using the erythrocyte...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21680
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle-aged individuals with hip or knee pain. Radiographs were assigned Kellgren & Lawrence (KL) scores under different conditions at each follow-up visit for 10 years. We aimed to describe and consolidate each scoring approach, then illustrate implicatio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24563
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVE:Competent examination of the pediatric musculoskeletal (MSK) system is a vital component of clinical assessment of children with MSK presentations. The aim was to develop a regional MSK examination for school-age children that is age appropriate and reflects clinical practice. METHODS:Qualitative and quantit...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20569
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to evaluate changes in knee magnetic resonance imaging (MRI) findings over the course of 18 months in subjects with osteoarthritic change and meniscal tear treated with arthroscopic partial meniscectomy (APM) or nonoperatively with physical therapy (PT). METHODS:We used 18-mo...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23891
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the effect of the Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) exercise program on hand function was mediated by changes in the proposed active ingredients: strength, dexterity, and/or range of motion. METHODS:The SARAH intervention included exercises hypothe...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23093
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of magnetic resonance imaging (MRI) osteoarthritis (OA) features in the patellofemoral or tibiofemoral joint (i.e., bone marrow lesions, cartilage lesions, and osteophytes) and/or functional impairments, 1 year following anterior cruciate ligament reconstruction (ACLR), can p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22761
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To compare 3 methods for calculating the Bath Ankylosing Spondylitis Metrology Index (BASMI) score using patients who participated in the GO-RAISE study. METHODS:Patients with active ankylosing spondylitis (AS) were randomly assigned in a 1:1.8:1.8 ratio to receive subcutaneous injections of placebo, golimum...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21771
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Approximately 20% of patients experience chronic pain after total knee replacement (TKR), yet there is no consensus about how best to assess such pain. This systematic review aimed to identify measures used to characterize chronic pain after TKR.Methods. MEDLINE, Embase, PsycINFO, Cochrane Library, and CINAHL...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22050
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Cachexia is a disorder characterized by involuntary weight loss in addition to loss of homeostatic control of both energy and protein balance. Despite an abundance of data from other inflammatory diseases, cachexia in SLE remains a largely undescribed syndrome. METHODS:2406 patients in a prospective SLE coho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24395
更新日期:2020-08-02 00:00:00
abstract:OBJECTIVE:To determine whether slower walking speed was associated with an increased risk of incident hip and knee osteoarthritis (OA)-related outcomes. METHODS:After providing informed consent, community-dwelling participants in the Johnston County Osteoarthritis Project completed 2 home-based interviews and an addit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21655
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Management of systemic lupus erythematosus (SLE) is complex and variability in practices exists. Guidelines have been developed to help improve the management of SLE patients, but there has been no formal evaluation of these guidelines. This study aims to compare the scope, quality, and consistency of clinica...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22591
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To examine the association of socioeconomic status (SES) and delays in disease-modifying antirheumatic drug (DMARD) treatment with clinical measures in rheumatoid arthritis (RA) patients. METHODS:RA patients were recruited from rheumatology practices. We assessed SES based on education, occupation, and incom...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:The US national prevalence of spondylarthritis (SpA) was estimated for 2 published sets of classification criteria: the Amor criteria and the European Spondylarthropathy Study Group (ESSG) criteria. These 2 SpA criteria sets have been the most widely utilized in previous population-based studies of SpA. METH...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21621
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Despite the high prevalence of depression among vulnerable Hispanics with rheumatoid arthritis (RA), many do not disclose it or seek treatment. This study explored patient perceptions of depression, its association with their primary disease, barriers to disclosure, reasons for low utilization of mental healt...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22462
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Disease activity, organ damage, and treatment burden are often substantial in children and adolescents with systemic lupus erythematous (SLE), and the complex interplay among the developing child, parents, and peers makes effective management difficult. We aimed to describe the experiences and perspectives of...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22749
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To assess the association of femoroacetabular impingement (FAI) and delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) T1 relaxation values (RVs), and to evaluate whether subtypes of FAI (cam, pincer, and mixed) are associated with region-specific dGEMRIC T1 RVs. METHODS:A populati...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23463
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:A recent study conducted by our clinical group demonstrated that low disease activity (LDA), defined as a clinical Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score ≤2, maintained for 12 months, confers the same risk for damage accrual as complete remission after 2 years. The aim of t...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23720
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between exposure to oral contraceptives (OCs) and clinical outcomes in an early arthritis cohort. METHODS:Female patients with early inflammatory arthritis, ages 18-60 years, who were enrolled in an early arthritis cohort and had no exposure to hormone replacement were studied (n ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22667
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:Fatigue is common among people with inflammatory arthritis but is hard to manage. The aim of this study was to investigate how daily fluctuations in psychological variables correspond with changes in fatigue-related disability in the daily lives of people with inflammatory arthritis to identify factors to ta...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24224
更新日期:2020-04-27 00:00:00
abstract:OBJECTIVE:To screen for a high risk of preeclampsia in women with systemic lupus erythematosus (SLE). METHODS:A total of 513 antenatal care records of pregnant patients with SLE were obtained, and the data were randomly assigned to either a development set (n = 342) or a validation set (n = 171). Preeclampsia predicto...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24265
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To understand the impact of ankylosing spondylitis (AS) on work disability (WD) over 12 years compared with the general population, and explore factors predicting adverse work outcome, defined as new partial WD or reduction in working hours. METHODS:Source of data was the Outcome Assessments in Ankylosing Sp...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22730
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. METHODS:Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20571
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To examine work absenteeism, job disruptions, and perceived productivity loss and factors associated with each outcome in young adults living with systemic lupus erythematosus (SLE) and juvenile arthritis (JA). METHODS:One hundred forty-three young adults, ages 18-30 years with SLE (54.5%) and JA (45.5%), co...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22601
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA). METHODS:This was an assessor-blinded, 3-arm randomized controlled trial in 22...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22744
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To identify a combination of clinical factors associated with low disease activity and remission in the third trimester during pregnancy in women with rheumatoid arthritis (RA). METHODS:This study is embedded in the Pregnancy-Induced Amelioration of Rheumatoid Arthritis study, a prospective cohort study. The...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23143
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To investigate differences in EMG muscle activity and scapular kinematics during elevation in the scapular plane between healthy controls, participants with multidirectional shoulder laxity (MDL), and patients with multidirectional shoulder instability (MDI) who are diagnosed with hypermobile Ehlers-Danlos sy...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24525
更新日期:2020-11-30 00:00:00
abstract:OBJECTIVE:Adherence to physical activity at ≥150 minutes/week has proven to offer disease management and health-promoting benefits among adults with arthritis. While highly active people seem undaunted by arthritis pain and are differentiated from the moderately active by adherence-related psychological factors, knowle...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22421
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:We propose new classification criteria for Sjögren's syndrome (SS), which are needed considering the emergence of biologic agents as potential treatments and their associated comorbidity. These criteria target individuals with signs/symptoms suggestive of SS. METHODS:Criteria are based on expert opinion elic...
journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
doi:10.1002/acr.21591
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To identify the principal determinants of health-related quality of life (HRQOL) impairment in patients with active primary Sjögren's syndrome (SS) participating in a large therapeutic trial, Tolerance and Efficacy of Rituximab in Primary Sjögren's Syndrome (TEARS). METHODS:At the inclusion visit for the TEA...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.22974
更新日期:2017-04-01 00:00:00