Abstract:
OBJECTIVE:To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. METHODS:Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was performed, in which clusters were formed based on similarities in 4 clinically relevant, easily available variables: severity of radiographic OA, lower extremity muscle strength, body mass index, and depression. Univariable and multivariable regression analyses were used to compare phenotypes on clinical outcomes (pain and activity limitations), taking into account possible confounders. RESULTS:Five phenotypes of knee OA patients were identified: "minimal joint disease phenotype," "strong muscle phenotype," "nonobese and weak muscle phenotype," "obese and weak muscle phenotype," and "depressive phenotype." The "depressive phenotype" and "obese and weak muscle phenotype" showed higher pain levels and more severe activity limitations than the other 3 phenotypes. CONCLUSION:Five phenotypes based on clinically relevant patient characteristics can be identified in the heterogeneous population of knee OA patients. These phenotypes showed different clinical outcomes. Interventions may need to be tailored to these clinical phenotypes.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Knoop J,van der Leeden M,Thorstensson CA,Roorda LD,Lems WF,Knol DL,Steultjens MP,Dekker Jdoi
10.1002/acr.20571subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1535-42issue
11eissn
2151-464Xissn
2151-4658journal_volume
63pub_type
杂志文章abstract:OBJECTIVE:To compare the time-varying behavior of maximum toe-out angle, lateral trunk lean (over the stance leg), and pelvic obliquity (rise and drop on the swing leg) during prolonged walking in participants with and without medial compartment knee osteoarthritis (OA), and to explore correlations between these gait c...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21584
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM). METHODS:We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi-square or Fisher's exact tests and used univariate and multivariate lo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22498
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease (CVD) risk. Pregnancy morbidities, including preeclampsia, and CVD are common in systemic lupus erythematosus (SLE). Possible connections are important to explore. In a population-based cohort, we investigated whether HDP is associated...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24160
更新日期:2020-01-31 00:00:00
abstract:OBJECTIVE:To determine whether the presence of magnetic resonance imaging (MRI) osteoarthritis (OA) features in the patellofemoral or tibiofemoral joint (i.e., bone marrow lesions, cartilage lesions, and osteophytes) and/or functional impairments, 1 year following anterior cruciate ligament reconstruction (ACLR), can p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22761
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:Milk consumption has long been recognized for its important role in bone health, but its role in the progression of knee osteoarthritis (OA) is unclear. We examined the prospective association of milk consumption with radiographic progression of knee OA. METHODS:In the Osteoarthritis Initiative, 2,148 partic...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22297
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To explore patients' knowledge and beliefs about osteoarthritis (OA) and OA risk following anterior cruciate ligament (ACL) injury, to explore the extent to which information about these risks is provided by health professionals, and to examine associations among participant characteristics, knowledge, and ri...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22794
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To examine trends in glucocorticoid (GC) use and dosing among patients diagnosed with rheumatoid arthritis (RA) over time. METHODS:A population-based inception cohort of RA patients diagnosed during 1980-2007 was followed longitudinally through their medical records until death, migration, or December 31, 20...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22365
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To determine if a pharmacist-initiated multidisciplinary strategy provides value for money compared to usual care in participants with previously undiagnosed knee osteoarthritis. METHODS:Pharmacies were randomly allocated to provide either 1) usual care and a pamphlet or 2) intervention care, which consisted...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22232
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:The University of California in San Diego Shortness of Breath Questionnaire (UCSD SOBQ) has been used to assess dyspnea-related activity limitation in patients with airway and parenchymal lung disease. We sought to assess the construct validity and responsiveness of the UCSD SOBQ in systemic sclerosis (SSc; s...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21827
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:The US national prevalence of spondylarthritis (SpA) was estimated for 2 published sets of classification criteria: the Amor criteria and the European Spondylarthropathy Study Group (ESSG) criteria. These 2 SpA criteria sets have been the most widely utilized in previous population-based studies of SpA. METH...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21621
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Large database research in axial spondyloarthritis (SpA) is limited by a lack of methods for identifying most types of axial SpA. Our objective was to develop methods for identifying axial SpA concepts in the free text of documents from electronic medical records. METHODS:Veterans with documents in the natio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23140
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between synovial vascularity and progression of structural bone damage in each finger joint in patients with rheumatoid arthritis (RA) and to demonstrate synovial vascularity as a potential therapeutic marker. METHODS:We studied 250 metacarpophalangeal (MCP) and 250 proximal i...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20517
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To examine the secular trend of hip fracture incidence in Belgium between 2000 and 2007 and the concomitant change in the prescriptions of antiosteoporosis medications. METHODS:The incidence of hip fractures and the number of prescriptions were determined using national databases. A logistic regression inclu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21607
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:Pulmonary arterial hypertension (PAH) is a rare but serious complication of systemic lupus erythematosus (SLE). Chronic hypoxia is known to cause PAH resulting from pulmonary vascular remodeling. We investigated the association between anemic hypoxia and PAH in SLE patients. METHODS:Systolic pulmonary artery...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22630
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To screen for a high risk of preeclampsia in women with systemic lupus erythematosus (SLE). METHODS:A total of 513 antenatal care records of pregnant patients with SLE were obtained, and the data were randomly assigned to either a development set (n = 342) or a validation set (n = 171). Preeclampsia predicto...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24265
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To develop and internally validate risk models and a clinical risk score tool to predict incident radiographic knee osteoarthritis (RKOA) in middle-aged women. METHODS:We analyzed 649 women in the Chingford 1,000 Women study. The outcome was incident RKOA, defined as Kellgren/Lawrence grade 0-1 at baseline a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23932
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Total knee arthroplasty (TKA) is a widely utilized and effective treatment option for end-stage knee osteoarthritis (OA). Knee OA is more prevalent among women compared to men, but there are limited data on the sex differences in surgical outcomes after primary TKA. METHODS:Our sample consisted of all primar...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21953
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Reactivation of Mycobacterium tuberculosis infection is a major complication in patients treated with anti-tumor necrosis factor (anti-TNF) agents. We report on the 5 cases of active tuberculosis (TB) that developed in the Golimumab Phase III Program (3 with rheumatoid arthritis, 1 with psoriatic arthritis, a...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21788
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To determine the extent to which demographic and geographic disparities exist in the use of post-acute rehabilitation care (PARC) for joint replacement. METHODS:We conducted a cross-sectional analysis of 2 years (2005 and 2006) of population-based hospital discharge data from 392 hospitals in 4 states (Arizo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20477
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23102
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To compare the performances of 3 comorbidity indices, the Charlson Comorbidity Index, the Elixhauser Comorbidity Index, and the Centers for Medicare & Medicaid Services (CMS) risk adjustment model, Hierarchical Condition Category (HCC), in predicting post-acute discharge settings and hospital readmission for ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23195
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Metacarpal juxtaarticular bone is altered in rheumatoid arthritis (RA). However, a detailed analysis of disease-related geometric adaptations of the metacarpal shaft is missing. The aim of the present study was to assess the role of RA disease, forearm muscle cross-sectional area (CSA), age, and sex on bone g...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20394
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To compare educational and vocational outcomes among adults with childhood-onset systemic lupus erythematosus (SLE) and adult-onset SLE. METHODS:We used data derived from the 2002–2010 cycles of the Lupus Outcomes Study, a longitudinal cohort of 1,204 adult subjects with SLE. Subjects ages 18–60 years living...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22228
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:We aimed to determine if there were sex differences in lean body mass (LBM) in patients with rheumatoid arthritis (RA) when compared with sex- and race-specific National Health and Nutrition Examination Survey (NHANES) reference data, and to investigate the impact of sex differences in risk factors for LBM de...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22396
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Medication access and adherence are important determinants of health outcomes. We investigated factors associated with access and cost-related non-adherence to prescriptions in a population-based cohort of systemic lupus erythematosus (SLE) patients and controls. METHODS:Detailed sociodemographic and prescr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24397
更新日期:2020-08-02 00:00:00
abstract:OBJECTIVE:To investigate whether height is associated with low back pain (LBP) and surgery, taking into account personal and socioeconomic risk factors in a general population. METHODS:In 2001, 13,680 participants of the Gazel cohort completed a self-reported questionnaire on LBP and surgery interventions. Three group...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20023
更新日期:2010-01-15 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations of diffuse idiopathic skeletal hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS:DISH and kyphosis were assessed in 1,500 men from the Osteoporotic Fractures in Men (MrOS) study and in 1,267 women from the Study of Osteoporotic Fr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23115
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To describe and compare triennial rates of physicians' recommendations for physical therapy (PT), lifestyle counseling, and pain medication for knee osteoarthritis (OA) and to identify patient, physician, and practice factors associated with each treatment recommendation. METHODS:We conducted a cross-section...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24064
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:To determine whether the effect of the Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) exercise program on hand function was mediated by changes in the proposed active ingredients: strength, dexterity, and/or range of motion. METHODS:The SARAH intervention included exercises hypothe...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23093
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Digital ulcers represent one of the most frequent complications of systemic sclerosis (SSc; scleroderma); they are very painful, scarcely responsive to treatment, and often responsible for marked limitations on daily activities, including patient self-care. Infectious complications may severely compromise the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20673
更新日期:2012-02-01 00:00:00