Abstract:
OBJECTIVE:Reactivation of Mycobacterium tuberculosis infection is a major complication in patients treated with anti-tumor necrosis factor (anti-TNF) agents. We report on the 5 cases of active tuberculosis (TB) that developed in the Golimumab Phase III Program (3 with rheumatoid arthritis, 1 with psoriatic arthritis, and 1 with ankylosing spondylitis) through 1 year among 2,210 patients receiving golimumab. METHODS:Data from global studies were used for an in-depth evaluation of the 5 cases of TB through week 52. Integrated safety data were evaluated for potential hepatotoxicity in patients treated with anti-TB therapy. RESULTS:No active TB developed among 317 patients receiving golimumab and treated for latent TB with isoniazid. Active TB occurred in 5 patients not treated with isoniazid by week 52 (in 2 patients by week 24); all of the patients had negative TB screening tests (per the local guidelines) and resided in countries with high background rates of TB. No deaths were due to TB. Across all of the groups (placebo and golimumab), alanine aminotransferase and aspartate aminotransferase elevations occurred in greater proportions of patients treated for latent TB infection versus not treated; elevations were largely mild (<3 times the upper limit of normal). CONCLUSION:Comprehensive TB screening kept the number of active TB cases relatively low despite conducting the studies in TB-endemic regions. Treatment for latent TB infection appeared effective, since no patients treated for latent TB had TB reactivation. Concurrent treatment with golimumab and anti-TB medication was generally well tolerated. Clinicians should remain vigilant for development of active TB after initiation of TNF inhibitors, since prompt diagnosis and treatment can improve outcomes.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Hsia EC,Cush JJ,Matteson EL,Beutler A,Doyle MK,Hsu B,Xu S,Rahman MUdoi
10.1002/acr.21788subject
Has Abstractpub_date
2013-02-01 00:00:00pages
309-13issue
2eissn
2151-464Xissn
2151-4658journal_volume
65pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To identify the principal determinants of health-related quality of life (HRQOL) impairment in patients with active primary Sjögren's syndrome (SS) participating in a large therapeutic trial, Tolerance and Efficacy of Rituximab in Primary Sjögren's Syndrome (TEARS). METHODS:At the inclusion visit for the TEA...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.22974
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Adherence to physical activity at ≥150 minutes/week has proven to offer disease management and health-promoting benefits among adults with arthritis. While highly active people seem undaunted by arthritis pain and are differentiated from the moderately active by adherence-related psychological factors, knowle...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22421
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence, incidence, and burden of gout in the Veterans Health Administration (VHA) from 2005-2014. METHODS:We used national VHA data from 1/1999-12/2014 to determine the annual incidence and prevalence of gout in the VHA. Gout burden to the VHA was determined by the proportion of patients...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24339
更新日期:2020-05-31 00:00:00
abstract:OBJECTIVE:To determine whether calcinosis and acro-osteolysis are related to specific nailfold videocapillaroscopy (NVC) features in patients with systemic sclerosis (SSc; scleroderma). METHODS:NVC and bilateral hand radiographs were systematically performed in 155 consecutively recruited patients with SSc during a 24...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22672
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23009
更新日期:2017-06-01 00:00:00
abstract::Objective: To test the hypothesis that cartilage displays significant longitudinal thickening in the external subregions of the central medial (ecMF) and lateral (ecLF) femur in knees with early radiographic osteoarthritis (ROA) compared with contralateral knees without ROA, and to explore differences in change in oth...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22172
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To clarify sex differences in early axial spondyloarthritis (SpA). METHODS:In total, 475 patients included in the Devenir des Spondylarthropathies Indifférenciées Récentes (Outcome of Recent Undifferentiated Spondylarthropathies) cohort, a prospective multicenter French cohort of patients with early inflamma...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22001
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Health information technology (HIT) holds promise in increasing access to rheumatologists by improving the quality and efficiency of referrals, but few studies have examined its use for this purpose. We evaluated the use and impact of a novel electronic referral (eReferral) system in rheumatology in a safety-...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22559
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA). METHODS:This was an assessor-blinded, 3-arm randomized controlled trial in 22...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22744
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To describe 1) a technique that can detect synovial effusions not seen on static ultrasound (US) examination and 2) the characteristics of patients with knee osteoarthritis (OA) for whom this technique proved useful. METHODS:From reviewed records of 76 patients with knee OA (112 knees) that we had seen for U...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20047
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Perceived discrimination is associated with chronic pain and depression and contributes to racial health disparities. In a cohort of older adult veterans with osteoarthritis (OA), our objective was to examine how membership in multiple socially disadvantaged groups (cumulative disadvantage) was associated wit...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.24481
更新日期:2021-01-01 00:00:00
abstract::History of the present illness: A four-year-old female presented to our pediatric rheumatology clinic with chief complaint of periodic fevers and abdominal pain. Fevers began 4 months prior to presentation following a documented streptococcal pharyngeal infection, with a maximum temperature of 104F. They occurred ever...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24428
更新日期:2020-08-19 00:00:00
abstract:OBJECTIVE:We propose new classification criteria for Sjögren's syndrome (SS), which are needed considering the emergence of biologic agents as potential treatments and their associated comorbidity. These criteria target individuals with signs/symptoms suggestive of SS. METHODS:Criteria are based on expert opinion elic...
journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
doi:10.1002/acr.21591
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of mycophenolate mofetil (MMF) and cyclophosphamide (CYC) on modified Rodnan skin score (MRSS) in participants enrolled in the Scleroderma Lung Study (SLS) I and II. METHODS:SLS I participants received daily oral CYC or matching placebo for 1 year, whereas SLS II participants received ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23282
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To describe the experiences and strategies of employees with arthritis to maintain employment, and to use this information to build a conceptual model. METHODS:We conducted a systematic review of qualitative studies that examined the work experiences of employees with arthritis. Published studies on arthriti...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23528
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:By 2030, the number of permanently homebound individuals in the US will increase by 50% to reach 2 million. However, no medicine subspecialty consult services exist for this rising subset of the population. This pilot program establishes a rheumatology consult service for the Mount Sinai Visiting Doctors, the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20539
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) is used as an anchor drug for rheumatoid arthritis (RA). Lymphoproliferative disease (LPD) occasionally develops in patients treated with MTX, and is known as MTX-associated LPD (MTX-LPD). Although MTX-LPD occurs mainly in RA patients, it has not been established if MTX administration is an...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22306
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To evaluate if exercise programs in trials for patients with ankylosing spondylitis (AS) have the potential for effectiveness. METHODS:A systematic literature search was performed and randomized trials examining the effectiveness of exercise programs for AS patients were analyzed according to 3 elements: whe...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20415
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To develop a clinical risk prediction tool to identify patients most likely to experience long-term clinically meaningful functional improvement following total hip arthroplasty (THA). METHODS:We studied 282 patients from 2 health districts in England (Portsmouth and North Staffordshire) who were ≥45 years o...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21594
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To determine factors that are predictive of incident, recurrent, or resolved shoulder pain in a community-based sample from the general population. METHODS:This study used data from the North West Adelaide Health Study, a cohort study located in the northwestern suburbs of Adelaide, South Australia. Data wer...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22082
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Although several individual nutrients/foods are associated with uric acid status, the association of overall diet quality with hyperuricemia remains unclear. We thus examined the association between adherence to the dietary approaches to stop hypertension (DASH) diet and odds of having hyperuricemia in a Chin...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24150
更新日期:2020-01-21 00:00:00
abstract:OBJECTIVE:To identify and evaluate the measurement properties of self-report physical activity instruments suitable for patients with osteoarthritis (OA). METHODS:We conducted a comprehensive 2-stage systematic review using multiple electronic databases, from inception until July 2018. In the stage 1 review, we sought...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23787
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:This study was performed to determine the prevalence of elevated C-reactive protein (CRP) levels and the significance of CRP in clinical parameters in systemic sclerosis (SSc; scleroderma) patients. METHODS:Canadian Scleroderma Research Group data were used. Statistical comparisons were made for CRP levels ≤...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21716
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate ixekizumab safety in adults with psoriatic arthritis (PsA). METHODS:Safety data from 2 integrated data sets are presented: 1) 24-week, double-blind, placebo-controlled period of SPIRIT-P1 and SPIRIT-P2; and 2) all ixekizumab-treated patients of SPIRIT-P1 and SPIRIT-P2 plus SPIRIT-P3 open-label pe...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.23738
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:There are few reports on the treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) in children. This study characterizes the use of cyclophosphamide, rituximab, and plasma exchange in children hospitalized with AAV in the US. METHODS:We conducted a retrospective cohort study of childre...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23142
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23102
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Competent examination of the pediatric musculoskeletal (MSK) system is a vital component of clinical assessment of children with MSK presentations. The aim was to develop a regional MSK examination for school-age children that is age appropriate and reflects clinical practice. METHODS:Qualitative and quantit...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20569
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The role of cardiovascular disease (CVD) risk factors in psoriatic arthritis (PsA) is poorly understood. We examined the prevalence of CVD risk factors at initial onset of PsA and compared the observed incidence of CVD events with that predicted by the Framingham Risk Score (FRS) to determine its applicabilit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22536
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations of diffuse idiopathic skeletal hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS:DISH and kyphosis were assessed in 1,500 men from the Osteoporotic Fractures in Men (MrOS) study and in 1,267 women from the Study of Osteoporotic Fr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23115
更新日期:2017-08-01 00:00:00