Abstract：
OBJECTIVE:Total knee arthroplasty (TKA) is a widely utilized and effective treatment option for end-stage knee osteoarthritis (OA). Knee OA is more prevalent among women compared to men, but there are limited data on the sex differences in surgical outcomes after primary TKA. METHODS:Our sample consisted of all primary TKAs performed in Pennsylvania during the fiscal year 2002. We used International Classification of Diseases, Ninth Revision, Clinical Modification codes to identify major complications and surgical revision. We used mixed-effects logistic regression models to examine the associations between sex and all-cause mortality, readmissions, and major surgical complications. We used proportional hazards models to assess the risk of surgical revision after index arthroplasty. We adjusted for race, age, hospital teaching status, hospital procedure volume, insurance status, and risk of mortality. RESULTS:In 17,994 primary TKAs, there were 46 and 220 deaths at 30 days and 1 year, respectively. Compared to women, men had higher adjusted odds of 1-year mortality (odds ratio [OR] 1.48 [95% confidence interval (95% CI) 1.13-1.94]) after primary TKA. The overall odds of most major 30-day complications did not differ by sex except for surgical wound infections, which were higher in men compared to women (OR 1.31 [95% CI 1.08-1.60]); 30-day readmission was higher in men (OR 1.25 [95% CI 1.10-1.43]). Men had significantly higher rates of revision of index knee arthroplasty at 5 years (hazard ratio 1.20 [95% CI 1.05-1.36]) compared to women. CONCLUSION:The higher rates of mortality, hospital readmissions, revision surgery, and wound infections in men undergoing elective primary TKA compared to women indicate there is a sex disparity in these outcomes.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Singh JA,Kwoh CK,Richardson D,Chen W,Ibrahim SAdoi
10.1002/acr.21953subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1095-102issue
7eissn
2151-464Xissn
2151-4658journal_volume
65pub_type
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journal_title：Arthritis care & research
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journal_title：Arthritis care & research
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journal_title：Arthritis care & research
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journal_title：Arthritis care & research
pub_type： 杂志文章,多中心研究
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journal_title：Arthritis care & research
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,随机对照试验
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更新日期：2017-07-01 00:00:00
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更新日期：2013-08-01 00:00:00
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journal_title：Arthritis care & research
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2020-01-21 00:00:00
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journal_title：Arthritis care & research
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：2020-04-05 00:00:00
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journal_title：Arthritis care & research
pub_type： 杂志文章
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更新日期：2020-05-31 00:00:00
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