Abstract:
OBJECTIVE:To evaluate the impact of anti-tumor necrosis factor (anti-TNF) therapies on quality of life (QOL) and functional status in psoriatic arthritis (PsA) patients and study potential predictors for QOL improvements. METHODS:The study was based on a cohort of 596 PsA patients receiving anti-TNF therapies. Changes in functional status and QOL were assessed using the Health Assessment Questionnaire (HAQ) and Short Form 36 (SF-36) questionnaire on a 6-month basis. The Short Form 6D (SF-6D) was calculated as a utility score. Univariate and multivariate linear regression models were developed to examine potential predictors of QOL improvements at 6 months, using a range of demographic, baseline disease-specific, and therapeutic variables. RESULTS:At 6 months, significant improvements in all SF-36 subscale scores were found, with the greatest percentage improvement from baseline related to physical role (113.8%; 95% confidence interval [95% CI] 102.6, 125.0). The percent improvement for the physical component scale was 53.2% (95% CI 44.5, 61.9) at 6 months, whereas that for the mental component scale was 16.9% (95% CI 14.7, 19.2). The mean +/- SD SF-6D score was 0.58 +/- 0.07 at baseline, and this improved to 0.63 +/- 0.06 at 6 months. The median HAQ score at baseline was 1.88 (interquartile range [IQR] 1.38-2.25) for the entire cohort, and this improved to 1.25 (IQR 0.63-1.88) at 6 months. Improvements in Disease Activity Score in 28 joints at 6 months were found to be significantly associated with QOL improvements at the same time point. CONCLUSION:Anti-TNF therapy is associated with improvement in both physical and mental status in PsA patients. These improvements were most substantial in patients who also had improvements in their disease activity.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Saad AA,Ashcroft DM,Watson KD,Symmons DP,Noyce PR,Hyrich KL,British Society for Rheumatology Biologics Register.doi
10.1002/acr.20104subject
Has Abstractpub_date
2010-03-01 00:00:00pages
345-53issue
3eissn
2151-464Xissn
2151-4658journal_volume
62pub_type
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journal_title:Arthritis care & research
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-06-01 00:00:00
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更新日期:2010-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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