Abstract:
OBJECTIVE:To examine temporal trends in mortality rates in a large nationwide cohort of patients with end-stage renal disease (ESRD) due to granulomatosis with polyangiitis (Wegener's) (GPA-ESRD). METHODS:We identified cases of GPA-ESRD reported in the US Renal Data System between 1995 and 2014, using coding by nephrologists for the cause of ESRD. The cohort was divided into four 5-year subcohorts based on the year of onset of ESRD (1995-1999, 2000-2004, 2005-2009, and 2010-2014) to assess trends in mortality rates and hazard ratios (HRs) for overall death and cause-specific death, adjusting for potential confounders. RESULTS:Between 1995 and 2014, there were 5,929 incident cases of GPA-ESRD. The mortality rate (incidence per 100 patient-years) declined from 19.0 in 1995-1999 to 15.3 in 2010-2014 (P for trend = 0.01). The multivariable-adjusted HR for mortality in the 2010-2014 cohort was 0.77 (95% confidence interval [95% CI] 0.66-0.90) (P for trend < 0.001 versus the 1995-1999 cohort). The corresponding cause-specific HRs for mortality, after accounting for competing risk, were 0.61 (95% CI 0.47-0.80) for CVD-related death and 0.42 (95% CI 0.28-0.63) for death due to infection (P for trend < 0.001). CONCLUSION:In this study of nearly all patients in whom GPA-ESRD developed in the US over 2 decades, we observed significant improvements in mortality among GPA-ESRD patients. The number of cause-specific deaths due to CVD and the number due to infections declined significantly during the study period. These findings are encouraging and likely reflect improved management of both GPA and ESRD.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Wallace ZS,Zhang Y,Lu N,Stone JH,Choi HKdoi
10.1002/acr.23521subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1495-1500issue
10eissn
2151-464Xissn
2151-4658journal_volume
70pub_type
杂志文章abstract:OBJECTIVE:Immunosuppressive therapy may trigger hepatitis B virus (HBV) reactivation for increased morbidity and mortality. We aimed to describe HBV reactivation in patients receiving treatment for immune-mediated inflammatory diseases (IMIDs) and to evaluate a predefined algorithm for its prevention. METHODS:Physicia...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.21990
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To determine rates of cervical cancer screening and associated abnormal results in women with systemic lupus erythematosus (SLE). METHODS:We identified women with an initial diagnosis of SLE in the MarketScan Commercial Claims and Encounters Database from 2001 to 2014. Cervical cancer screening rates and ass...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24414
更新日期:2020-08-16 00:00:00
abstract:OBJECTIVE:To assess experimental pain sensitivity and compare the inflammatory response to pain in 26 osteoarthritis (OA) patients and 33 age- and sex-matched controls from the general population in order to examine the nature of the association between pain and inflammation in OA. METHODS:The participants underwent p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20373
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The availability of reliable estimates of the burden of musculoskeletal disease is of considerable importance for policymakers. METHODS:This study uses data from the 14,507 participants of the European Health Interview Survey conducted in Austria in 2006/2007 to calculate estimates of the prevalence of osteo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20558
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Metacarpal juxtaarticular bone is altered in rheumatoid arthritis (RA). However, a detailed analysis of disease-related geometric adaptations of the metacarpal shaft is missing. The aim of the present study was to assess the role of RA disease, forearm muscle cross-sectional area (CSA), age, and sex on bone g...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20394
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To develop and internally validate risk models and a clinical risk score tool to predict incident radiographic knee osteoarthritis (RKOA) in middle-aged women. METHODS:We analyzed 649 women in the Chingford 1,000 Women study. The outcome was incident RKOA, defined as Kellgren/Lawrence grade 0-1 at baseline a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23932
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Reactivation of Mycobacterium tuberculosis infection is a major complication in patients treated with anti-tumor necrosis factor (anti-TNF) agents. We report on the 5 cases of active tuberculosis (TB) that developed in the Golimumab Phase III Program (3 with rheumatoid arthritis, 1 with psoriatic arthritis, a...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21788
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Medication access and adherence are important determinants of health outcomes. We investigated factors associated with access and cost-related non-adherence to prescriptions in a population-based cohort of systemic lupus erythematosus (SLE) patients and controls. METHODS:Detailed sociodemographic and prescr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24397
更新日期:2020-08-02 00:00:00
abstract:OBJECTIVE:Independent investigations have shown that socioeconomic status (SES) and learned helplessness (LH) are associated with poor disease outcome in patients with rheumatoid arthritis (RA). Our aim was to investigate the cross-sectional relationship between SES, LH, and disease outcome in patients with recent-onse...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21677
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Cachexia is a disorder characterized by involuntary weight loss in addition to loss of homeostatic control of both energy and protein balance. Despite an abundance of data from other inflammatory diseases, cachexia in SLE remains a largely undescribed syndrome. METHODS:2406 patients in a prospective SLE coho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24395
更新日期:2020-08-02 00:00:00
abstract:OBJECTIVE:The University of California in San Diego Shortness of Breath Questionnaire (UCSD SOBQ) has been used to assess dyspnea-related activity limitation in patients with airway and parenchymal lung disease. We sought to assess the construct validity and responsiveness of the UCSD SOBQ in systemic sclerosis (SSc; s...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21827
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To establish priority key messages for patients with osteoarthritis (OA). METHODS:A Delphi survey and priority pairwise ranking activity was conducted. Participants included 51 OA experts from 13 countries and 9 patients (consumers) living with hip and/or knee OA. During 3 Delphi rounds, the panel of experts...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22518
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To examine the association between weight change from young adulthood to midlife and risk of incident arthritis. METHODS:Using data from the National Health and Nutrition Examination Survey (NHANES), we categorized participants into weight change categories based on their recalled weight during young adultho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24252
更新日期:2020-05-06 00:00:00
abstract:OBJECTIVE:To investigate demographic, symptom-related, and cognitive determinants of cane use for knee osteoarthritis (OA) and prioritize the factors that could facilitate cane use in people with no previous cane use. METHODS:A survey of people ages ≥45 years with a clinical diagnosis of knee OA was conducted. The sur...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23494
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To assess the frequency of fibromyalgia syndrome (FMS), depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's) (GPA). METHODS:The London Fibromyalgia Epidemiologic Study Screening Questionnaire (LFESSQ), Symptom Intensity Scale, Epworth Sleepiness Scale (ESS), and the B...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20442
更新日期:2011-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20477
更新日期:2011-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22396
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Prior studies have established disparities by race/ethnicity and socioeconomic status (SES) in the kind, quantity, and technical quality of systemic lupus erythematosus (SLE) care and outcomes. In this study we evaluate whether disparities exist in assessments of interactions with health care providers and he...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22427
更新日期:2015-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21611
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To determine the impact of stopping tumor necrosis factor inhibitor (TNFi) treatment on patient-reported outcomes (PROs) of physical and mental health status, health utility, pain, disability, and fatigue in patients with established rheumatoid arthritis (RA). METHODS:In the pragmatic, 12-month POET trial, 8...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23315
更新日期:2018-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21655
更新日期:2012-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22686
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Foot involvement is a major feature in rheumatoid arthritis (RA), leading to structural deformities. Methods to allow a 3-dimensional (3-D) evaluation of foot structure in RA to be applicable in daily clinical practice have not been evaluated. This study assessed the use of a foot digitizer, a noninvasive 3-D...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21794
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To compare the performances of 3 comorbidity indices, the Charlson Comorbidity Index, the Elixhauser Comorbidity Index, and the Centers for Medicare & Medicaid Services (CMS) risk adjustment model, Hierarchical Condition Category (HCC), in predicting post-acute discharge settings and hospital readmission for ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23195
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Pulmonary arterial hypertension (PAH) is a rare but serious complication of systemic lupus erythematosus (SLE). Chronic hypoxia is known to cause PAH resulting from pulmonary vascular remodeling. We investigated the association between anemic hypoxia and PAH in SLE patients. METHODS:Systolic pulmonary artery...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22630
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Systemic sclerosis (SSc) is an autoimmune disease that can cause disfiguring changes in appearance. This study examined the structural validity, internal consistency reliability, convergent validity, and measurement equivalence of the Social Appearance Anxiety Scale (SAAS) across SSc disease subtypes. METHOD...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23514
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To identify and evaluate the measurement properties of self-report physical activity instruments suitable for patients with osteoarthritis (OA). METHODS:We conducted a comprehensive 2-stage systematic review using multiple electronic databases, from inception until July 2018. In the stage 1 review, we sought...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23787
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To describe the perception of the current role of systemic glucocorticoids in the management of rheumatoid arthritis (RA) by examining their importance and the current level of evidence in recent guidelines, and to identify open questions to be addressed in future guidelines and research projects. METHODS:We...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.23185
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability. METHODS:Subjects included 898 older persons from the Rush Memory and Aging Project without dementia, stroke, or Parkinson's disease at baseline. All participants underwent detailed baseline eva...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20200
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:We propose new classification criteria for Sjögren's syndrome (SS), which are needed considering the emergence of biologic agents as potential treatments and their associated comorbidity. These criteria target individuals with signs/symptoms suggestive of SS. METHODS:Criteria are based on expert opinion elic...
journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
doi:10.1002/acr.21591
更新日期:2012-04-01 00:00:00