Abstract:
OBJECTIVE:To determine whether slower walking speed was associated with an increased risk of incident hip and knee osteoarthritis (OA)-related outcomes. METHODS:After providing informed consent, community-dwelling participants in the Johnston County Osteoarthritis Project completed 2 home-based interviews and an additional clinic visit for radiographic and physical evaluation. One thousand eight hundred fifty-eight noninstitutionalized residents ages ≥ 45 years living for at least 1 year in 1 of 6 townships in Johnston County, North Carolina, completed the study's questionnaires and clinical examinations at baseline and at followup testing. Walking time was assessed using a manual stopwatch in 2 trials over an 8-foot distance, and walking speed was calculated as the average of both trials. For the hip and knee, we examined 3 outcomes per joint site: radiographic OA (weight-bearing anteroposterior knee radiographs, supine anteroposterior pelvic radiographs of the hip), chronic joint symptoms, and symptomatic OA. Covariates included age, sex, race, education, marital status, body mass index, number of self-reported chronic conditions diagnosed by a health care provider, number of prescriptions, depressive symptoms, self-rated health, number of lower body functional limitations, smoking, and physical activity. RESULTS:Faster walking speed was consistently associated with a lower incidence of radiographic (adjusted odds ratio [OR] 0.88, 95% confidence interval [95% CI] 0.79-0.97) and symptomatic knee OA (adjusted OR 0.84, 95% CI 0.75-0.95); slower walking speed was associated with a greater incidence of these outcomes across a broad range of different clinical and radiographic OA outcomes. CONCLUSION:Slower walking speed may be a marker for incident knee OA, but other studies must confirm this finding.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Purser JL,Golightly YM,Feng Q,Helmick CG,Renner JB,Jordan JMdoi
10.1002/acr.21655subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1028-35issue
7eissn
2151-464Xissn
2151-4658journal_volume
64pub_type
杂志文章abstract:OBJECTIVE:This double-blind randomized controlled trial aimed to test the efficacy of self-administered acupressure for pain and physical function improvement for older adults with knee osteoarthritis (OA). METHODS:Participants were community-dwelling adults with symptomatic knee OA (n = 150, mean age 73 years), rando...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23262
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To investigate the existence and distribution of 2 typologies (termed "factors") of men with rheumatoid arthritis (RA) identified through our previous Q-methodology study (n = 30) in a larger sample of men with RA, and whether differences in psychosocial impact or support preferences exist between the 2 facto...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23422
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To examine the differential presentation(s) of psychological and health-related outcomes in young adults with juvenile-onset fibromyalgia (FM) with and without a history of trauma, compared to healthy controls. METHODS:In total, 110 participants (86 with juvenile-onset FM and 24 healthy controls, with a mean...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23192
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of magnetic resonance imaging (MRI) osteoarthritis (OA) features in the patellofemoral or tibiofemoral joint (i.e., bone marrow lesions, cartilage lesions, and osteophytes) and/or functional impairments, 1 year following anterior cruciate ligament reconstruction (ACLR), can p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22761
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To determine whether a decline in walking speed during the year prior to disease onset is associated with concurrent changes in cartilage, bone marrow lesions (BMLs), or effusion in adults who develop common knee osteoarthritis (OA), accelerated knee OA, or no knee OA. METHODS:We identified 3 groups from the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23613
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Low-dose aspirin may reduce the risk of developing rheumatoid arthritis (RA) through its effect on cyclooxygenase activity and its antioxidant pathways. Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorect...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20042
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To examine the association between weight change from young adulthood to midlife and risk of incident arthritis. METHODS:Using data from the National Health and Nutrition Examination Survey (NHANES), we categorized participants into weight change categories based on their recalled weight during young adultho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24252
更新日期:2020-05-06 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) has been linked to functional disability and increased risk of falls, but mechanisms underpinning functional disability are unclear. This study investigated functional performance, muscle strength, and plantar pressures in adults with mild, moderate, and severe HV compared to controls, whil...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22380
更新日期:2015-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21699
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease (CVD) risk. Pregnancy morbidities, including preeclampsia, and CVD are common in systemic lupus erythematosus (SLE). Possible connections are important to explore. In a population-based cohort, we investigated whether HDP is associated...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-01-31 00:00:00
abstract:OBJECTIVE:To assess the impact of weekly text messages on adherence in patients taking methotrexate (MTX) for rheumatoid arthritis (RA). METHODS:This prospective, randomized pilot, single-site study included patients with RA stabilized using MTX alone or combined with biologics. Participants were randomized to 3 inter...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
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更新日期:2019-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23285
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Ankle-foot problems have a considerable impact on daily functioning in patients with hypermobile Ehlers-Danlos syndrome and Hypermobility Spectrum Disorder (hEDS/HSD). Therefore, the objective of this study is to identify alterations in multi-segment ankle and foot kinematics during gait and assessing foot fu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24526
更新日期:2020-12-04 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23494
更新日期:2018-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24483
更新日期:2020-10-12 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.23279
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM). METHODS:We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi-square or Fisher's exact tests and used univariate and multivariate lo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22498
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti-NXP-2) antibodies. METHODS:We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employin...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22959
更新日期:2017-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21874
更新日期:2013-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23996
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To develop and pilot test a screening tool to identify cases of nephrogenic systemic fibrosis (NSF) among patients exposed to gadolinium-containing contrast agents. METHODS:Sixty English-speaking subjects were enrolled: 10 subjects diagnosed as having NSF, 10 subjects with other fibrosing skin diseases, 20 s...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To evaluate time trends in mortality for hospitalized adults with systemic lupus erythematosus (SLE) compared to the general hospitalized population (GHP), and to identify factors associated with increased risk of death among hospitalized SLE patients. METHODS:We used the National (Nationwide) Inpatient Samp...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24356
更新日期:2020-06-17 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) is used as an anchor drug for rheumatoid arthritis (RA). Lymphoproliferative disease (LPD) occasionally develops in patients treated with MTX, and is known as MTX-associated LPD (MTX-LPD). Although MTX-LPD occurs mainly in RA patients, it has not been established if MTX administration is an...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22306
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To identify the principal determinants of health-related quality of life (HRQOL) impairment in patients with active primary Sjögren's syndrome (SS) participating in a large therapeutic trial, Tolerance and Efficacy of Rituximab in Primary Sjögren's Syndrome (TEARS). METHODS:At the inclusion visit for the TEA...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.22974
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Little is known about the natural history of knee osteoarthritis (OA). We sought to identify common patterns of joint space narrowing (JSN) in well-characterized knee OA patients in the placebo arm of a 2-year international study. METHODS:We performed secondary data analyses of 622 adults ages 39-80 years in...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.20614
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Perceived discrimination is associated with chronic pain and depression and contributes to racial health disparities. In a cohort of older adult veterans with osteoarthritis (OA), our objective was to examine how membership in multiple socially disadvantaged groups (cumulative disadvantage) was associated wit...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2021-01-01 00:00:00