Abstract:
OBJECTIVE:Low-dose aspirin may reduce the risk of developing rheumatoid arthritis (RA) through its effect on cyclooxygenase activity and its antioxidant pathways. Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorectal adenomas, but no trial has evaluated the role of aspirin in RA prevention. METHODS:The Women's Health Study is a randomized, double-blind, placebo-controlled trial conducted between 1992 and 2004 designed to evaluate the risks and benefits of low-dose aspirin (100 mg every other day) and vitamin E in the primary prevention of cardiovascular disease and cancer among 39,876 female health care professionals age > or =45 years throughout the US. After excluding women with RA at baseline, 39,144 women were evaluated for the present study. A definite diagnosis of RA was assessed during followup by self-report and confirmed using a connective tissue disease screening questionnaire, followed by a medical record review by a rheumatologist for American College of Rheumatology criteria. RESULTS:During an average followup of 10 years, 106 women developed definite RA (48 women in the aspirin group and 58 in the placebo group). There was a nonsignificant risk for RA (relative risk [RR] 0.83, 95% confidence interval [95% CI] 0.56-1.21; P = 0.33) associated with aspirin. There were 64 seropositive RA cases (60%) and 42 seronegative RA cases (40%). Aspirin also had no significant effect on either seropositive RA (RR 1.0, 95% CI 0.61-1.63) or seronegative RA (RR 0.62, 95% CI 0.33-1.15). CONCLUSION:One hundred milligrams of aspirin taken every other day was not associated with a significant reduction in the risk of developing RA among women in a randomized, double-blind, placebo-controlled trial.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Shadick NA,Karlson EW,Cook NR,Maher NE,Buring JE,Lee IMdoi
10.1002/acr.20042subject
Has Abstractpub_date
2010-04-01 00:00:00pages
545-50issue
4eissn
2151-464Xissn
2151-4658journal_volume
62pub_type
杂志文章abstract:OBJECTIVE:To compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases. METHODS:This was a cross-sectional multicenter study where the prevalence of more relevant comorbiditie...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23015
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle-aged individuals with hip or knee pain. Radiographs were assigned Kellgren & Lawrence (KL) scores under different conditions at each follow-up visit for 10 years. We aimed to describe and consolidate each scoring approach, then illustrate implicatio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24563
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the feasibility and effectiveness of neuromuscular electrical stimulation (NMES) with that of high-intensity volitional resistance training for improving muscle structure and function and physical function in patients with rheumatoid arthritis (RA). We also compared pre-in...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23602
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:The RhoA/Rho kinase pathway plays a pivotal role in cold-induced vasoconstriction, vascular smooth muscle cells function, and vascular homeostasis. This study evaluates the efficacy of fasudil, a RhoA/Rho kinase inhibitor, to reverse cold-induced vasospasm in patients with Raynaud's phenomenon (RP) secondary ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21622
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To identify and describe back pain trajectory groups and to compare indicators of health status, medication, and health care use in these groups. METHODS:A representative sample (n = 12,782) of the Canadian population was followed-up from 1994/1995 to 2010/2011. Participants were interviewed biannually and p...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23811
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To describe the effect of different exposure classification strategies for disease-modifying antirheumatic drugs (DMARDs) on drug-outcome associations. METHODS:We studied the association between DMARD initiation and all-cause hospitalizations in patients with rheumatoid arthritis (RA), 1995-2005. Initiators ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20087
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:In early rheumatoid arthritis (RA), treating to a target is more effective than routine care (RC). Our aim was to determine if treating to a target has better outcomes than RC in established active RA. METHODS:We used a real-world, 18-month cluster-randomized trial in established active RA patients treated w...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22010
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To describe the experiences and strategies of employees with arthritis to maintain employment, and to use this information to build a conceptual model. METHODS:We conducted a systematic review of qualitative studies that examined the work experiences of employees with arthritis. Published studies on arthriti...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23528
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability. METHODS:Subjects included 898 older persons from the Rush Memory and Aging Project without dementia, stroke, or Parkinson's disease at baseline. All participants underwent detailed baseline eva...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20200
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Total knee arthroplasty (TKA) is a widely utilized and effective treatment option for end-stage knee osteoarthritis (OA). Knee OA is more prevalent among women compared to men, but there are limited data on the sex differences in surgical outcomes after primary TKA. METHODS:Our sample consisted of all primar...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21953
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To compare 3 methods for calculating the Bath Ankylosing Spondylitis Metrology Index (BASMI) score using patients who participated in the GO-RAISE study. METHODS:Patients with active ankylosing spondylitis (AS) were randomly assigned in a 1:1.8:1.8 ratio to receive subcutaneous injections of placebo, golimum...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21771
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Married persons have, on average, better mental health than nonmarried persons. Among married persons, marital satisfaction is associated with better mental health. Studies on mental health in married and nonmarried persons that consider marital satisfaction have categorized patients as satisfied versus unsat...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22802
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oxidative stress is increased in patients with rheumatoid arthritis (RA) due to increased inflammation and contributes to the pathogenesis of atherosclerosis. METHODS:The independent association between urinary F₂-isoprostane excretion, a measure of oxidative stress, and RA was te...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20237
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To examine clinical characteristics as possible predictors of long-term treatment continuation with adalimumab, etanercept, and infliximab in ankylosing spondylitis (AS) patients who had never taken biologics treated in clinical practice. METHODS:Patients in southern Sweden with active AS starting biologic t...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20258
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To determine the extent to which thigh intermuscular fat (IMF) and quadriceps muscle (QM) volumes explained variance in knee extensor strength and physical performance in women with radiographic knee osteoarthritis (ROA) and without. METHODS:Baseline data from 125 women (age ≥50 years) in the Osteoarthritis ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21868
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Since 2014, rheumatology fellows have been assessed not only based on their ability to provide patient care and possess medical knowledge but also on their skill in serving as patient advocates, navigators of health systems, and members of a health care team. Such assessments have been carried out through the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24507
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVE:To develop and pilot test a screening tool to identify cases of nephrogenic systemic fibrosis (NSF) among patients exposed to gadolinium-containing contrast agents. METHODS:Sixty English-speaking subjects were enrolled: 10 subjects diagnosed as having NSF, 10 subjects with other fibrosing skin diseases, 20 s...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.21877
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To investigate the response of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) by ultrasonographic evaluation of changes in the wrist and hand, and to determine whether such assessments during early TCZ treatment predict later clinical outcome. METHODS:Thirty-two RA patients about to receive TCZ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20537
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS:Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and methodologists generated key clinical questions to be addressed ...
journal_title:Arthritis care & research
pub_type: 杂志文章,实务指引
doi:10.1002/acr.23871
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Interrater variability limits rheumatologic opinion as a reference standard for early inflammatory arthritis (IA) classification. The study objectives were to determine whether rheumatologic opinion is associated with potential early IA classification methods despite high interrater variability, and to compar...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1002/acr.20250
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To compare the relative effectiveness of anti-tumor necrosis factor (anti-TNF) therapies on health-related quality of life (HRQOL) by inflammatory arthritis types. METHODS:Patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) who had anti-TNF therapy (etanercept,...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22151
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. METHODS:Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20571
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To clarify sex differences in early axial spondyloarthritis (SpA). METHODS:In total, 475 patients included in the Devenir des Spondylarthropathies Indifférenciées Récentes (Outcome of Recent Undifferentiated Spondylarthropathies) cohort, a prospective multicenter French cohort of patients with early inflamma...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22001
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Adherence to physical activity at ≥150 minutes/week has proven to offer disease management and health-promoting benefits among adults with arthritis. While highly active people seem undaunted by arthritis pain and are differentiated from the moderately active by adherence-related psychological factors, knowle...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22421
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between exposure to oral contraceptives (OCs) and clinical outcomes in an early arthritis cohort. METHODS:Female patients with early inflammatory arthritis, ages 18-60 years, who were enrolled in an early arthritis cohort and had no exposure to hormone replacement were studied (n ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22667
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the prevalence, incidence, and mortality rates of autoimmune rheumatic diseases (ARDs) by using a population-based database. METHODS:We used the longitudinal health insurance database (comprising 1,000,000 beneficiaries) of the Taiwan National Health Insurance from ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21820
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To determine whether a decline in walking speed during the year prior to disease onset is associated with concurrent changes in cartilage, bone marrow lesions (BMLs), or effusion in adults who develop common knee osteoarthritis (OA), accelerated knee OA, or no knee OA. METHODS:We identified 3 groups from the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23613
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash of DM without objective muscle weakness. Asian studies report that anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in CADM is associated with interstitial lung dis...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22728
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To determine if mortality is increased among patients diagnosed as having fibromyalgia. METHODS:We studied 8,186 fibromyalgia patients seen between 1974 and 2009 in 3 settings: all fibromyalgia patients in a clinical practice, patients participating in the US National Data Bank for Rheumatic Diseases (NDB), ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20301
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:We aimed to determine if there were sex differences in lean body mass (LBM) in patients with rheumatoid arthritis (RA) when compared with sex- and race-specific National Health and Nutrition Examination Survey (NHANES) reference data, and to investigate the impact of sex differences in risk factors for LBM de...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22396
更新日期:2015-01-01 00:00:00