Abstract:
OBJECTIVE:The RhoA/Rho kinase pathway plays a pivotal role in cold-induced vasoconstriction, vascular smooth muscle cells function, and vascular homeostasis. This study evaluates the efficacy of fasudil, a RhoA/Rho kinase inhibitor, to reverse cold-induced vasospasm in patients with Raynaud's phenomenon (RP) secondary to systemic sclerosis (SSc; scleroderma). METHODS:This is a single-center, double-blind, placebo-controlled, randomized, 3-period crossover study of oral fasudil (40 mg or 80 mg) or placebo administered 2 hours before a standardized cold challenge. The fall in skin temperature after the cold challenge and time to recover 50% and 70% of prechallenge digital skin temperature were used as primary outcomes. Digital blood flow assessed by laser Doppler, time to minimum skin temperature, and rate of skin cooling were also measured. RESULTS:A total of 17 patients with SSc and RP completed the study. After the cold challenge, skin temperatures and the average time (minutes) to recover 50% (7.9 minutes for placebo, 7.5 minutes for fasudil 40 mg, and 8.2 minutes for fasudil 80 mg; P = 0.791) and 70% (18.2 minutes for placebo, 15.0 minutes for fasudil 40 mg, and 17.1 minutes for fasudil 80 mg; P = 0.654) of prechallenge skin temperature were not significantly different across the 3 groups. The digital blood flow measurements were higher in fasudil-treated groups than placebo, but differences were not significant (P = 0.693). CONCLUSION:Fasudil administered at a single oral dose of 40 mg or 80 mg was not associated with significant benefit in terms of the skin temperature recovery time and the digital blood flow after the cold challenge.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Fava A,Wung PK,Wigley FM,Hummers LK,Daya NR,Ghazarian SR,Boin Fdoi
10.1002/acr.21622subject
Has Abstractpub_date
2012-06-01 00:00:00pages
925-9issue
6eissn
2151-464Xissn
2151-4658journal_volume
64pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To describe and compare triennial rates of physicians' recommendations for physical therapy (PT), lifestyle counseling, and pain medication for knee osteoarthritis (OA) and to identify patient, physician, and practice factors associated with each treatment recommendation. METHODS:We conducted a cross-section...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24064
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:To compare T1ρ relaxation times of the medial and lateral regions of the patella and femoral trochlea at 6 and 12 months post-anterior cruciate ligament reconstruction (ACLR) on the ACLR and contralateral limb. Greater T1ρ relaxation times are associated with a lesser proteoglycan density of articular cartila...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24561
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVE:To determine rates of cervical cancer screening and associated abnormal results in women with systemic lupus erythematosus (SLE). METHODS:We identified women with an initial diagnosis of SLE in the MarketScan Commercial Claims and Encounters Database from 2001 to 2014. Cervical cancer screening rates and ass...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24414
更新日期:2020-08-16 00:00:00
abstract:OBJECTIVE:To study the epidemiology of hospitalized serious infections in people with gout. METHODS:We identified people with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract infection (UTI), skin and soft tissue infections (SSTI), or opportunistic infections (OI) in 1998-2016 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24201
更新日期:2020-04-05 00:00:00
abstract:OBJECTIVE:To analyze trends in opioid prescriptions during visits to office-based physicians made by adults with arthritis in the US from 2006 to 2015. METHODS:We analyzed nationally representative data on patient visits to office-based physicians from the National Ambulatory Medical Care Survey (NAMCS) 2006-2015. Vis...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24447
更新日期:2020-09-16 00:00:00
abstract:OBJECTIVE:Management of systemic lupus erythematosus (SLE) is complex and variability in practices exists. Guidelines have been developed to help improve the management of SLE patients, but there has been no formal evaluation of these guidelines. This study aims to compare the scope, quality, and consistency of clinica...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22591
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To investigate the response of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) by ultrasonographic evaluation of changes in the wrist and hand, and to determine whether such assessments during early TCZ treatment predict later clinical outcome. METHODS:Thirty-two RA patients about to receive TCZ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20537
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether patients affected by 1 of the 3 subsets of early systemic sclerosis (SSc; scleroderma), i.e., subset I, Raynaud's phenomenon with SSc marker autoantibodies and typical capillaroscopic findings; subset II, autoantibody positive only; and subset III, capillaroscopy positive only and not s...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22304
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23285
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To describe the experiences and strategies of employees with arthritis to maintain employment, and to use this information to build a conceptual model. METHODS:We conducted a systematic review of qualitative studies that examined the work experiences of employees with arthritis. Published studies on arthriti...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23528
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease (CVD) risk. Pregnancy morbidities, including preeclampsia, and CVD are common in systemic lupus erythematosus (SLE). Possible connections are important to explore. In a population-based cohort, we investigated whether HDP is associated...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24160
更新日期:2020-01-31 00:00:00
abstract:OBJECTIVE:To assess the efficacy of mycophenolate mofetil (MMF) and cyclophosphamide (CYC) on modified Rodnan skin score (MRSS) in participants enrolled in the Scleroderma Lung Study (SLS) I and II. METHODS:SLS I participants received daily oral CYC or matching placebo for 1 year, whereas SLS II participants received ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23282
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The influence of specific medications on the risk of postoperative infection in patients with rheumatoid arthritis and other inflammatory rheumatic diseases (IRDs) remains unclear. This retrospective study examined the risk of postoperative infection at the site of surgery in patients treated with immunosuppr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22077
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis (RA) due to its effectiveness, tolerability, and cost. This study examines MTX prescribing practices in the US from 2009 to 2014. METHODS:Symphony Health Solutions, which covers 274 million patients in the US, was used to identify...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23152
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Approximately 20% of patients experience chronic pain after total knee replacement (TKR), yet there is no consensus about how best to assess such pain. This systematic review aimed to identify measures used to characterize chronic pain after TKR.Methods. MEDLINE, Embase, PsycINFO, Cochrane Library, and CINAHL...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22050
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To portray experiences of women engaging in everyday tasks, activities, and occupations, from symptom onset to 12 months after diagnosis with rheumatoid arthritis (RA), and to explore the meanings attributed to their activities and occupations. METHODS:A secondary analysis of qualitative data, guided by phen...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20668
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To develop recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP). METHODS:We conducted a systematic review to synthesize the evidence for the benefits and harms of GIOP prevention and treatment options. The Grading of Recommendations Assessment, Development and Evaluation...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.23279
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To evaluate if exercise programs in trials for patients with ankylosing spondylitis (AS) have the potential for effectiveness. METHODS:A systematic literature search was performed and randomized trials examining the effectiveness of exercise programs for AS patients were analyzed according to 3 elements: whe...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20415
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To explore the link between a patient acceptable symptom state (PASS) and patient-perceived impact in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS:This was a cross-sectional study of unselected patients with definite RA or PsA. Pain, functional capacity, fatigue, coping, and sleep disturb...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23176
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Studies have implicated foot posture and foot function as risk factors for lower extremity pain. Empirical population-based evidence for this assertion is lacking; therefore, the purpose of this study was to evaluate cross-sectional associations of foot posture and foot function to lower extremity joint pain ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22049
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The Veterans Affairs (VA) Rheumatoid Arthritis (VARA) registry and the VA Pharmacy Benefits Management database were linked to determine the association of methotrexate (MTX) adherence with rheumatoid arthritis (RA) disease activity. METHODS:For each patient, the medication possession ratio (MPR) was calcula...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20629
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Total knee replacement (TKR) is an effective treatment for end-stage knee osteoarthritis (OA). American racial minorities undergo fewer TKRs than whites. We estimated quality-adjusted life-years (QALYs) lost for African American knee OA patients due to differences in TKR offer, acceptance, and complication ra...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23484
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether height is associated with low back pain (LBP) and surgery, taking into account personal and socioeconomic risk factors in a general population. METHODS:In 2001, 13,680 participants of the Gazel cohort completed a self-reported questionnaire on LBP and surgery interventions. Three group...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20023
更新日期:2010-01-15 00:00:00
abstract::The illness started with pain and stiffness in her bilateral hands and wrists four months prior, with progression to bilateral elbows, knees, and ankles. The pain and stiffness were worse in the morning and limited her ability to use her hands or walk comfortably. She also noted swelling of her hands, knees, and ankle...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24141
更新日期:2020-01-21 00:00:00
abstract:OBJECTIVE:Omission of foot joints from composite global disease activity indices may lead to underestimation of foot and overall disease in rheumatoid arthritis (RA) and under-treatment. The aim of this study was to evaluate the measurement properties of the Rheumatoid Arthritis Foot Disease Activity Index-5 (RADAI-F5)...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24259
更新日期:2020-05-20 00:00:00
abstract:OBJECTIVE:To determine whether there is a temporal association between arthritis and uveitis activity among children with juvenile idiopathic arthritis-associated uveitis (JIA-U). METHODS:Uveitis and arthritis data from JIA-U patients ≤21 years were collected from 7/2013-12/2019 at a tertiary care center. Arthritis ac...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24483
更新日期:2020-10-12 00:00:00
abstract:OBJECTIVE:By 2030, the number of permanently homebound individuals in the US will increase by 50% to reach 2 million. However, no medicine subspecialty consult services exist for this rising subset of the population. This pilot program establishes a rheumatology consult service for the Mount Sinai Visiting Doctors, the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20539
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Competent examination of the pediatric musculoskeletal (MSK) system is a vital component of clinical assessment of children with MSK presentations. The aim was to develop a regional MSK examination for school-age children that is age appropriate and reflects clinical practice. METHODS:Qualitative and quantit...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20569
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To develop and internally validate risk models and a clinical risk score tool to predict incident radiographic knee osteoarthritis (RKOA) in middle-aged women. METHODS:We analyzed 649 women in the Chingford 1,000 Women study. The outcome was incident RKOA, defined as Kellgren/Lawrence grade 0-1 at baseline a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23932
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between exposure to oral contraceptives (OCs) and clinical outcomes in an early arthritis cohort. METHODS:Female patients with early inflammatory arthritis, ages 18-60 years, who were enrolled in an early arthritis cohort and had no exposure to hormone replacement were studied (n ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22667
更新日期:2016-03-01 00:00:00