Abstract:
OBJECTIVE:The influence of specific medications on the risk of postoperative infection in patients with rheumatoid arthritis and other inflammatory rheumatic diseases (IRDs) remains unclear. This retrospective study examined the risk of postoperative infection at the site of surgery in patients treated with immunosuppressive drugs (including biologic agents) undergoing different types of orthopedic surgery. METHODS:The study included 50,359 cases of orthopedic surgery performed in our hospital between 2000 and 2008. The primary outcome was operation-related infection. IRD patients were compared with those with degenerative or posttraumatic disorders, and in IRD patients, the effect of immunosuppressive medication, specifically tumor necrosis factor α (TNFα) inhibitors and their preoperative management, was examined. RESULTS:There were 373 operation-related infections (0.8%) of 47,887 cases in the degenerative/posttraumatic group and 49 (2.0%) of 2,472 in the IRD group (higher infection rate in the IRD group; odds ratio [OR] 2.58 [95% confidence interval (95% CI) 1.91-3.48], P < 0.001). In the IRD group, elbow and foot surgery had the highest infection rates. The risk of infection was significantly increased in patients taking multiple conventional disease-modifying antirheumatic drugs (DMARDs; OR 2.49 [95% CI 1.06-5.84], P = 0.036) or TNFα inhibitors (OR 2.54 [95% CI 1.08-5.97], P = 0.032). The risk was especially high (6 [12%] of 49) if the last dose of TNFα inhibitor was given <1 administration interval before surgery. CONCLUSION:The risk of postoperative infection was elevated in patients with IRDs, especially those taking >1 conventional DMARD or TNFα inhibitors. It may be advisable to consider stopping TNFα inhibitors ≥1 administration interval before surgery, since the risk of postoperative infection appears to be higher if the operation occurs within this period.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Scherrer CB,Mannion AF,Kyburz D,Vogt M,Kramers-de Quervain IAdoi
10.1002/acr.22077subject
Has Abstractpub_date
2013-12-01 00:00:00pages
2032-40issue
12eissn
2151-464Xissn
2151-4658journal_volume
65pub_type
杂志文章abstract:OBJECTIVE:Lower extremity functional performance and perception of functional abilities influence clinical management in people diagnosed with unilateral or bilateral knee osteoarthritis (OA). The purpose of this study was to determine if there were differences in perception of function and performance during functiona...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21825
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:Children with juvenile idiopathic arthritis (JIA) experience functional impairment due to joint manifestations of the disease. The aim of our present study was to assess health-related quality of life (HRQOL) and its predictors in a group of children and adolescents with JIA. METHODS:The study sample include...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21609
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To establish priority key messages for patients with osteoarthritis (OA). METHODS:A Delphi survey and priority pairwise ranking activity was conducted. Participants included 51 OA experts from 13 countries and 9 patients (consumers) living with hip and/or knee OA. During 3 Delphi rounds, the panel of experts...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22518
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:The California Lupus Surveillance Project (CLSP) is a population-based registry of individuals with systemic lupus erythematosus (SLE) residing in San Francisco County, California from 2007 to 2009, with a special focus on Asian/Pacific Islander and Hispanic patients. We used retrospective CLSP data to analyz...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23887
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Competent examination of the pediatric musculoskeletal (MSK) system is a vital component of clinical assessment of children with MSK presentations. The aim was to develop a regional MSK examination for school-age children that is age appropriate and reflects clinical practice. METHODS:Qualitative and quantit...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20569
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Prior investigations demonstrated that autoantibodies recognizing cytosolic 5'-nucleotidase 1A (NT5C1A) are found in 33-76% of patients with inclusion body myositis (IBM) but are observed only rarely in patients with polymyositis (PM). Thus, anti-NT5C1A may help distinguish IBM from PM. Although 4-21% of pati...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22600
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To test the validity and reliability of screening instruments for depression and anxiety in rheumatoid arthritis (RA). METHODS:Participants with RA completed the Patient Health Questionnaire (PHQ-2 or PHQ-9), the Patient Reported Outcomes Measurement Information System depression short form 8a and anxiety sh...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24011
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Large database research in axial spondyloarthritis (SpA) is limited by a lack of methods for identifying most types of axial SpA. Our objective was to develop methods for identifying axial SpA concepts in the free text of documents from electronic medical records. METHODS:Veterans with documents in the natio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23140
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:The US national prevalence of spondylarthritis (SpA) was estimated for 2 published sets of classification criteria: the Amor criteria and the European Spondylarthropathy Study Group (ESSG) criteria. These 2 SpA criteria sets have been the most widely utilized in previous population-based studies of SpA. METH...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21621
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Digital ulcers represent one of the most frequent complications of systemic sclerosis (SSc; scleroderma); they are very painful, scarcely responsive to treatment, and often responsible for marked limitations on daily activities, including patient self-care. Infectious complications may severely compromise the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20673
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Systemic sclerosis (SSc) is an autoimmune disease that can cause disfiguring changes in appearance. This study examined the structural validity, internal consistency reliability, convergent validity, and measurement equivalence of the Social Appearance Anxiety Scale (SAAS) across SSc disease subtypes. METHOD...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23514
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To evaluate heterogeneity of treatment effects (HTE) in a trial of exercise-based interventions for knee osteoarthritis (OA). METHODS:Participants (n=350) were randomized to standard physical therapy (PT; n=140), Internet-Based Exercise Training (IBET; n=142), or wait list control (WL; n=68). We applied QUal...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24564
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVE:Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin-1 (IL-1) and IL-6 inhibitors appear to be effective treatments. Pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), and alveolar proteinosis (AP) have recently been reported ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21889
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Treat-to-target strategies have improved outcomes in rheumatic diseases. In psoriatic arthritis (PsA), the proposed targets are the multidimensional target minimal disease activity (MDA) and the articular target Disease Activity index for PsA (DAPSA). The aim of this study was to compare the disease burden of...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23571
更新日期:2018-12-01 00:00:00
abstract::The illness started with pain and stiffness in her bilateral hands and wrists four months prior, with progression to bilateral elbows, knees, and ankles. The pain and stiffness were worse in the morning and limited her ability to use her hands or walk comfortably. She also noted swelling of her hands, knees, and ankle...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24141
更新日期:2020-01-21 00:00:00
abstract:OBJECTIVE:Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash of DM without objective muscle weakness. Asian studies report that anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in CADM is associated with interstitial lung dis...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22728
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The present study attempted to fill a research gap by performing the first dimensionality analysis of the Revised Fibromyalgia Impact Questionnaire (FIQR) using exploratory and confirmatory techniques. A second objective was to report on the reliability and construct validity of the FIQR in Spanish patients. ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22034
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To validate the pediatric Patient-Reported Outcomes Measurement Information System short forms (PROMIS-SFs) in childhood-onset systemic lupus erythematosus (SLE) in a clinical setting. METHODS:At 3 study visits, childhood-onset SLE patients completed the PROMIS-SFs (anger, anxiety, depressive symptoms, fatig...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22927
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Little is known about the natural history of knee osteoarthritis (OA). We sought to identify common patterns of joint space narrowing (JSN) in well-characterized knee OA patients in the placebo arm of a 2-year international study. METHODS:We performed secondary data analyses of 622 adults ages 39-80 years in...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.20614
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To assess the long-term outcome in eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA). METHODS:A total of 101 patients fulfilling the American College of Rheumatology criteria for EGPA were included between 1990 and 2011. Clinical features, antineutrophil cytoplasm autoantibodies (ANCAs), a...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22686
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To assess health-related quality of life (HRQOL) in abatacept-treated children/adolescents with juvenile idiopathic arthritis (JIA). METHODS:In this phase III, double-blind, placebo-controlled trial, subjects with active polyarticular course JIA and an inadequate response/intolerance to ≥1 disease-modifying ...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/acr.20283
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease (CVD) risk. Pregnancy morbidities, including preeclampsia, and CVD are common in systemic lupus erythematosus (SLE). Possible connections are important to explore. In a population-based cohort, we investigated whether HDP is associated...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24160
更新日期:2020-01-31 00:00:00
abstract:OBJECTIVE:To determine rates of cervical cancer screening and associated abnormal results in women with systemic lupus erythematosus (SLE). METHODS:We identified women with an initial diagnosis of SLE in the MarketScan Commercial Claims and Encounters Database from 2001 to 2014. Cervical cancer screening rates and ass...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24414
更新日期:2020-08-16 00:00:00
abstract:OBJECTIVE:Disease activity, organ damage, and treatment burden are often substantial in children and adolescents with systemic lupus erythematous (SLE), and the complex interplay among the developing child, parents, and peers makes effective management difficult. We aimed to describe the experiences and perspectives of...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22749
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To summarize the potential predictors of remission in patients with rheumatoid arthritis (RA). METHODS:We performed a systematic review of prognostic studies that identified the predictors of remission in RA patients. Studies were identified in Medline, EMBase, and the Cochrane Registry, and by hand search. ...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20188
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Medication access and adherence are important determinants of health outcomes. We investigated factors associated with access and cost-related non-adherence to prescriptions in a population-based cohort of systemic lupus erythematosus (SLE) patients and controls. METHODS:Detailed sociodemographic and prescr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24397
更新日期:2020-08-02 00:00:00
abstract:OBJECTIVE:To examine cross-sectionally whether intraabdominal fat area (IAFA), i.e., visceral fat, and liver fat assessed by computed tomography (CT) are independently associated with hyperuricemia. METHODS:Subjects were 801 Japanese men not taking antidiabetic, antihypertensive, or urate-lowering medications, without...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22729
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:Fibromyalgia (FM) is a chronic painful condition partly due to alterations in pain modulation by the central nervous system. Multicomponent therapy (MT) and repetitive transcranial magnetic stimulation (rTMS) had both been reported as pain modulators in FM patients. The aim of this study was to compare the e...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24118
更新日期:2019-11-30 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine the sensitivity of the new 2013 classification criteria for systemic sclerosis (SSc; scleroderma) in an independent cohort of SSc subjects and to assess the contribution of individual items of the criteria to the overall sensitivity. METHODS:SSc subjects from the Canad...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22451
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Two surveys were conducted with patients with rheumatologic diseases to evaluate perceptions of different routes of administration (intravenous [IV] or subcutaneous [SC]) for biologic therapy. METHODS:In Survey I, patient preferences toward biologic treatment were evaluated at a rheumatology practice in Buff...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23758
更新日期:2019-09-01 00:00:00