Abstract:
OBJECTIVE:To summarize the potential predictors of remission in patients with rheumatoid arthritis (RA). METHODS:We performed a systematic review of prognostic studies that identified the predictors of remission in RA patients. Studies were identified in Medline, EMBase, and the Cochrane Registry, and by hand search. We included only studies performing multivariate analysis. RESULTS:A total of 18 studies from 2,062 citations were included. The following variables were found to be the independent predictors of RA remission: male sex; young age; late-onset RA; short disease duration; nonsmoker; low baseline disease activity; mild functional impairment; low baseline radiographic damage; absence of rheumatoid factor and anti-citrullinated peptide; low serum level of acute-phase reactant, interleukin-2, and RANKL at baseline; MTHFR 677T alleles and 1298C alleles in the methotrexate (MTX)-treated patients; magnetization transfer ratio 2756A allele +/- either the SLC 19A180A allele or the TYMS 3R-del6 haplotype in the MTX plus sulfasalazine combination-treated patients; early treatment with nonbiologic disease-modifying antirheumatic drug (DMARD) combinations; the use of anti-tumor necrosis factor (anti-TNF); the concurrent use of DMARDs in anti-TNF-treated patients; and moderate or good response to treatments at the first 6 months. The magnitude of the association in the individual predictor was diverse among the studies depending on the patient characteristics, the study characteristics, and the variables used to adjust for in the models. CONCLUSION:A number of independent predictors of remission, i.e., baseline clinical and laboratory characteristics and genetic markers, were summarized. The predictive value of prognostic factors recently identified needs to be confirmed.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Katchamart W,Johnson S,Lin HJ,Phumethum V,Salliot C,Bombardier Cdoi
10.1002/acr.20188subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1128-43issue
8eissn
2151-464Xissn
2151-4658journal_volume
62pub_type
杂志文章,评审abstract:OBJECTIVE:Management of systemic lupus erythematosus (SLE) is complex and variability in practices exists. Guidelines have been developed to help improve the management of SLE patients, but there has been no formal evaluation of these guidelines. This study aims to compare the scope, quality, and consistency of clinica...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22591
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine the sensitivity of the new 2013 classification criteria for systemic sclerosis (SSc; scleroderma) in an independent cohort of SSc subjects and to assess the contribution of individual items of the criteria to the overall sensitivity. METHODS:SSc subjects from the Canad...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22451
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Osteoarthritis (OA), a chronic degenerative joint disorder, is characterized by joint pain. Emerging research demonstrates that a significant number of patients evidence central sensitization (CS), a hyperexcitability in nociceptive pathways, which is known to amplify and maintain clinical pain. The clinical ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22609
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oxidative stress is increased in patients with rheumatoid arthritis (RA) due to increased inflammation and contributes to the pathogenesis of atherosclerosis. METHODS:The independent association between urinary F₂-isoprostane excretion, a measure of oxidative stress, and RA was te...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20237
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To determine if mortality is increased among patients diagnosed as having fibromyalgia. METHODS:We studied 8,186 fibromyalgia patients seen between 1974 and 2009 in 3 settings: all fibromyalgia patients in a clinical practice, patients participating in the US National Data Bank for Rheumatic Diseases (NDB), ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20301
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To examine the prevalence of sleep disturbances in adults with arthritis in a nationally representative sample, mediators of sleep difficulties, and subgroups of individuals with arthritis at greatest risk. METHODS:Using data on US adults ages≥18 years participating in the 2007 National Health Interview Surv...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20362
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23102
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To assess the long-term outcome in eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA). METHODS:A total of 101 patients fulfilling the American College of Rheumatology criteria for EGPA were included between 1990 and 2011. Clinical features, antineutrophil cytoplasm autoantibodies (ANCAs), a...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22686
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Differences in lipid levels associated with cardiovascular (CV) risk between rheumatoid arthritis (RA) patients and the general population remain unclear. Determining these differences is important in understanding the role of lipids in CV risk in RA. METHODS:We studied 2,005 RA subjects from 2 large academi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22091
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To examine the temporal and dose-related effects of glucocorticoids (GCs) on body mass index (BMI) in children with rheumatic diseases. METHODS:Children initiating GCs for a rheumatic disease (n = 130) were assessed every 3 months for 18 months. BMI, weight, and height Z score trajectories were described acc...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21785
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to evaluate changes in knee magnetic resonance imaging (MRI) findings over the course of 18 months in subjects with osteoarthritic change and meniscal tear treated with arthroscopic partial meniscectomy (APM) or nonoperatively with physical therapy (PT). METHODS:We used 18-mo...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23891
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Total knee replacement (TKR) is an effective treatment for end-stage knee osteoarthritis (OA). American racial minorities undergo fewer TKRs than whites. We estimated quality-adjusted life-years (QALYs) lost for African American knee OA patients due to differences in TKR offer, acceptance, and complication ra...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23484
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM). METHODS:We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi-square or Fisher's exact tests and used univariate and multivariate lo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22498
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti-NXP-2) antibodies. METHODS:We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employin...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23210
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:The risk of thrombotic events is elevated in patients with systemic lupus erythematosus (SLE) compared to the general population, and has been attributed to both systemic inflammation, as well as presence of antiphospholipid antibodies (aPL). We examined differences in aPL prevalence in Caucasian and African ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24508
更新日期:2020-11-10 00:00:00
abstract:OBJECTIVE:Health information technology (HIT) holds promise in increasing access to rheumatologists by improving the quality and efficiency of referrals, but few studies have examined its use for this purpose. We evaluated the use and impact of a novel electronic referral (eReferral) system in rheumatology in a safety-...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22559
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To understand the impact of ankylosing spondylitis (AS) on work disability (WD) over 12 years compared with the general population, and explore factors predicting adverse work outcome, defined as new partial WD or reduction in working hours. METHODS:Source of data was the Outcome Assessments in Ankylosing Sp...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22730
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To compare T1ρ relaxation times of the medial and lateral regions of the patella and femoral trochlea at 6 and 12 months post-anterior cruciate ligament reconstruction (ACLR) on the ACLR and contralateral limb. Greater T1ρ relaxation times are associated with a lesser proteoglycan density of articular cartila...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24561
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVE:To assess the efficacy of mycophenolate mofetil (MMF) and cyclophosphamide (CYC) on modified Rodnan skin score (MRSS) in participants enrolled in the Scleroderma Lung Study (SLS) I and II. METHODS:SLS I participants received daily oral CYC or matching placebo for 1 year, whereas SLS II participants received ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23282
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy, tolerability, and safety of cannabinoids (phyto- and syntheto-) in the management of rheumatic diseases. METHODS:Multiple databases, including Medline, Embase, and CENTRAL, were searched. Randomized controlled trials with outcomes of pain, sleep, quality of life, tolerability (dropout...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22727
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To explore patients' knowledge and beliefs about osteoarthritis (OA) and OA risk following anterior cruciate ligament (ACL) injury, to explore the extent to which information about these risks is provided by health professionals, and to examine associations among participant characteristics, knowledge, and ri...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22794
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate differences in EMG muscle activity and scapular kinematics during elevation in the scapular plane between healthy controls, participants with multidirectional shoulder laxity (MDL), and patients with multidirectional shoulder instability (MDI) who are diagnosed with hypermobile Ehlers-Danlos sy...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24525
更新日期:2020-11-30 00:00:00
abstract:OBJECTIVE:Up to 20% of people who undergo total knee replacement surgery have ongoing pain and discomfort. The aim of this study was to understand what role the concepts of embodiment (of both having a body and experiencing the world through one's body) and incorporation (integrating something into one's body) might ha...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24534
更新日期:2020-12-08 00:00:00
abstract:OBJECTIVE:To compare the relative effectiveness of anti-tumor necrosis factor (anti-TNF) therapies on health-related quality of life (HRQOL) by inflammatory arthritis types. METHODS:Patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) who had anti-TNF therapy (etanercept,...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22151
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. METHODS:All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox pro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22991
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of anti-tumor necrosis factor (anti-TNF) therapies on quality of life (QOL) and functional status in psoriatic arthritis (PsA) patients and study potential predictors for QOL improvements. METHODS:The study was based on a cohort of 596 PsA patients receiving anti-TNF therapies. Changes...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20104
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:The Psoriatic Arthritis Disease Activity Score (PASDAS) is a composite measure of psoriatic arthritis (PsA) disease activity. The length of its patient-reported components raises concern about questionnaire burden. The PASDAS includes the Medical Outcomes Study Short Form 36 (SF-36) health survey. We undertoo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23876
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability. METHODS:Subjects included 898 older persons from the Rush Memory and Aging Project without dementia, stroke, or Parkinson's disease at baseline. All participants underwent detailed baseline eva...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20200
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Fatigue is common among individuals with systemic lupus erythematosus (SLE), but the causes are not well understood. Our objective was to examine perceived stress and depressive symptoms as predictors of fatigue in SLE. METHODS:Data from 2 years of the Lupus Outcomes Study (n = 650 patients), obtained throug...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24052
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To determine the clinical manifestations and disease damage associated with discoid rash in a large multiethnic systemic lupus erythematosus (SLE) cohort. METHODS:SLE patients (per American College of Rheumatology [ACR] criteria) ages ≥16 years with a disease duration of ≤10 years at enrollment and defined e...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21581
更新日期:2012-05-01 00:00:00