Abstract:
OBJECTIVE:Fatigue is common among individuals with systemic lupus erythematosus (SLE), but the causes are not well understood. Our objective was to examine perceived stress and depressive symptoms as predictors of fatigue in SLE. METHODS:Data from 2 years of the Lupus Outcomes Study (n = 650 patients), obtained through annual structured interviews, were used. Fatigue was measured with the Short Form 36 (SF-36) vitality scale along with a variety of self-report measures of disease, depression, and stress. Multivariate linear regression models examined predictors of changes in fatigue. Model 1 tested the association of time 1 (T1) depression with time 2 (T2) fatigue; model 2 added T1 perceived stress to model 1, and final models added T1-to-T2 decrease in stress. All analyses controlled for T1 fatigue, age, sex, self-report of fibromyalgia, pain, and SLE duration, activity, and damage. RESULTS:Mean ± SD age was 51 ± 12 years, 92% of participants were women, and 68% were white. The mean ± SD SF-36 fatigue score was 55 ± 24. T1 depression significantly predicted T2 fatigue. When T1 stress was added, stress (β = 1.7 [95% confidence interval (95% CI) 1.1, 2.2]; P < 0.0001) significantly predicted T2 fatigue, but depression was no longer significant. The addition of T1-to-T2 decrease in stress was associated with a clinically meaningful decline in fatigue (β = -11.8 [95% CI -15.6, -8.9]; P < 0.0001). CONCLUSION:While depressive symptoms initially predicted subsequent fatigue, the effects were mediated by stress. A decrease in stress, in addition, was associated with a clinically meaningful decrease in fatigue. These results suggest that perceived stress plays an important role in SLE fatigue and may be an important focus of interventions for fatigue.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Azizoddin DR,Jolly M,Arora S,Yelin E,Katz Pdoi
10.1002/acr.24052subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1440-1448issue
10eissn
2151-464Xissn
2151-4658journal_volume
72pub_type
杂志文章abstract:OBJECTIVE:Functional ability and participation in life situations are compromised in many primary Sjögren's syndrome (SS) patients. This study aimed to identify the key barriers and priorities to participation in daily living activities, in order to develop potential future interventions. METHODS:Group concept mapping...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23536
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To assess experimental pain sensitivity and compare the inflammatory response to pain in 26 osteoarthritis (OA) patients and 33 age- and sex-matched controls from the general population in order to examine the nature of the association between pain and inflammation in OA. METHODS:The participants underwent p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20373
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To explore the link between a patient acceptable symptom state (PASS) and patient-perceived impact in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS:This was a cross-sectional study of unselected patients with definite RA or PsA. Pain, functional capacity, fatigue, coping, and sleep disturb...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23176
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Several lines of evidence have emphasized an improvement in aerobic capacity and muscle strength after physical exercise programs in rheumatoid arthritis (RA) patients. Our objective was to evaluate the efficacy of aerobic exercises in RA on quality of life, function, and clinical and radiologic outcomes by a...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析,评审
doi:10.1002/acr.20146
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To summarize the potential predictors of remission in patients with rheumatoid arthritis (RA). METHODS:We performed a systematic review of prognostic studies that identified the predictors of remission in RA patients. Studies were identified in Medline, EMBase, and the Cochrane Registry, and by hand search. ...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20188
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether people who report both arthritis and back problems report poorer health outcomes than those who have either condition alone. METHODS:We performed an analysis of the 2005 Canadian Community Health Survey (n = 126,049, age ≥15 years). Respondents were asked about long-term chronic health...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20595
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To evaluate if exercise programs in trials for patients with ankylosing spondylitis (AS) have the potential for effectiveness. METHODS:A systematic literature search was performed and randomized trials examining the effectiveness of exercise programs for AS patients were analyzed according to 3 elements: whe...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20415
更新日期:2011-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24507
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVE:Despite the joint pain and significant dysfunction that characterizes arthritis, many people with arthritis continue to carry out everyday duties and responsibilities. Our objective was to describe participation in informal caregiving (unpaid assistance to someone with a health issue or limitation) among peop...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24329
更新日期:2020-05-31 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20668
更新日期:2012-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23915
更新日期:2020-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23427
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of valgus knee bracing on pain and function, and compliance and complications, in patients with medial knee osteoarthritis (OA). METHODS:A meta-analysis of randomized controlled trials that compared changes in patient-reported pain and/or function in patients with medial knee OA was p...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.22472
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Children with juvenile idiopathic arthritis (JIA) experience functional impairment due to joint manifestations of the disease. The aim of our present study was to assess health-related quality of life (HRQOL) and its predictors in a group of children and adolescents with JIA. METHODS:The study sample include...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21609
更新日期:2012-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,实务指引
doi:10.1002/acr.23871
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The California Lupus Surveillance Project (CLSP) is a population-based registry of individuals with systemic lupus erythematosus (SLE) residing in San Francisco County, California from 2007 to 2009, with a special focus on Asian/Pacific Islander and Hispanic patients. We used retrospective CLSP data to analyz...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23887
更新日期:2020-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22228
更新日期:2014-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
doi:10.1002/acr.23531
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:The Patient Health Questionnaire 9 (PHQ-9) was developed to screen for depressive disorders in community, primary care, and medical settings. We aimed to estimate its diagnostic accuracy, internal consistency, reliability, and convergent validity in diagnosing major depressive disorder (MDD) in Greek patients...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20505
更新日期:2011-09-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22744
更新日期:2016-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23720
更新日期:2019-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22385
更新日期:2014-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22151
更新日期:2014-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21785
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Prior studies have established disparities by race/ethnicity and socioeconomic status (SES) in the kind, quantity, and technical quality of systemic lupus erythematosus (SLE) care and outcomes. In this study we evaluate whether disparities exist in assessments of interactions with health care providers and he...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22427
更新日期:2015-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22095
更新日期:2014-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21970
更新日期:2013-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23255
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Ankle-foot problems have a considerable impact on daily functioning in patients with hypermobile Ehlers-Danlos syndrome and Hypermobility Spectrum Disorder (hEDS/HSD). Therefore, the objective of this study is to identify alterations in multi-segment ankle and foot kinematics during gait and assessing foot fu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24526
更新日期:2020-12-04 00:00:00