Abstract:
OBJECTIVE:Differences in lipid levels associated with cardiovascular (CV) risk between rheumatoid arthritis (RA) patients and the general population remain unclear. Determining these differences is important in understanding the role of lipids in CV risk in RA. METHODS:We studied 2,005 RA subjects from 2 large academic medical centers. We extracted electronic medical record data on the first low-density lipoprotein (LDL) measurement, and total cholesterol and high-density lipoprotein (HDL) measurements within 1 year of the LDL measurement. Subjects with an electronic statin prescription prior to the first LDL measurement were excluded. We compared lipid levels in RA patients to recently published levels from the general US population using the t-test and stratifying by published parameters, i.e., 2007-2010, and women. We determined lipid trends using separate linear regression models for total cholesterol, LDL cholesterol, and HDL cholesterol, testing the association between year of measurement (1989-2010) and lipid level, adjusted by age and sex. Lipid trends in RA were qualitatively compared to the published general population trends. RESULTS:Women with RA had a significantly lower total cholesterol (186 versus 200 mg/dl; P = 0.002) and LDL cholesterol (105 versus 118 mg/dl; P = 0.001) compared to the general population (2007-2010). HDL cholesterol was not significantly different in the 2 groups. In the RA cohort, total cholesterol and LDL cholesterol significantly decreased each year, while HDL cholesterol increased (all with P < 0.0001), consistent with overall trends observed in a previous study. CONCLUSION:RA patients appear to have an overall lower total cholesterol and LDL cholesterol than the general population despite the general overall risk of CV disease in RA from observational studies.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Liao KP,Cai T,Gainer VS,Cagan A,Murphy SN,Liu C,Churchill S,Shaw SY,Kohane I,Solomon DH,Plenge RM,Karlson EWdoi
10.1002/acr.22091subject
Has Abstractpub_date
2013-12-01 00:00:00pages
2046-50issue
12eissn
2151-464Xissn
2151-4658journal_volume
65pub_type
杂志文章abstract:OBJECTIVE:To examine the secular trend of hip fracture incidence in Belgium between 2000 and 2007 and the concomitant change in the prescriptions of antiosteoporosis medications. METHODS:The incidence of hip fractures and the number of prescriptions were determined using national databases. A logistic regression inclu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21607
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:Since 2014, rheumatology fellows have been assessed not only based on their ability to provide patient care and possess medical knowledge but also on their skill in serving as patient advocates, navigators of health systems, and members of a health care team. Such assessments have been carried out through the...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-11-12 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-11-09 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2010-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2017-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22591
更新日期:2015-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21622
更新日期:2012-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 信件
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更新日期:2020-07-23 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/acr.23996
更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23521
更新日期:2018-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22095
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21820
更新日期:2013-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2013-09-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.20681
更新日期:2012-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20087
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1002/acr.23738
更新日期:2019-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20647
更新日期:2012-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23282
更新日期:2018-03-01 00:00:00