Abstract:
OBJECTIVE:To evaluate time trends in mortality for hospitalized adults with systemic lupus erythematosus (SLE) compared to the general hospitalized population (GHP), and to identify factors associated with increased risk of death among hospitalized SLE patients. METHODS:We used the National (Nationwide) Inpatient Sample to estimate all-cause mortality for adults discharged from U.S. community hospitals between 2006 and 2016. Poisson regression models were used to estimate the risk of in-hospital death among all patients, including demographics, socioeconomic factors, comorbidity score, hospital region, SLE diagnosis and race/ethnicity as covariates. RESULTS:Among 340,467,049 hospitalizations analyzed, 1,903,279 had a discharge diagnosis of SLE. In adjusted analysis, the risk of inpatient death decreased among hospitalizations for patients with SLE from 2.2% to 1.5% (p-value<0.001) between 2006 and 2016. All of the decrease in SLE mortality occurred between 2006 and 2008; after 2008, mortality stabilized at a rate statistically similar to the GHP. Hospitalizations for Blacks, Hispanics, and Asian/Pacific Islanders with SLE were more likely to end in death compared to hospitalizations for either whites with SLE, or individuals of the same non-white race/ethnicity without SLE. CONCLUSIONS:In the largest study of in-hospital SLE mortality published to date, we found significant improvements in mortality for U.S. hospitalized patients with SLE from 2006 until 2008, after which mortality stabilized at a level similar to that of the GHP. Our results also demonstrate a persistently high mortality burden among U.S. Blacks and Hispanics with SLE, and contribute new data revealing high mortality among Asian/Pacific Islanders with SLE.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Anastasiou C,Trupin L,Glidden DV,Li J,Gianfrancesco M,Shiboski S,Schmajuk G,Yazdany Jdoi
10.1002/acr.24356subject
Has Abstractpub_date
2020-06-17 00:00:00eissn
2151-464Xissn
2151-4658pub_type
杂志文章abstract:OBJECTIVE:To identify and evaluate the measurement properties of self-report physical activity instruments suitable for patients with osteoarthritis (OA). METHODS:We conducted a comprehensive 2-stage systematic review using multiple electronic databases, from inception until July 2018. In the stage 1 review, we sought...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23787
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We compared patient-reported outcomes (PROs) in patients with RA treated with tofacitinib or placebo in combination with conventional disease-modifying antirheumatic drugs (DMARDs). METHODS:In a 12-month, phase III ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23004
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To determine whether perceptions of clinical manifestations (fatigue, pain, and physical limitation) of rheumatoid arthritis (RA) differ between spouses and their partners with RA, and to determine whether the differences are associated with the perception of beneficial and problematic spousal social support....
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20330
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To determine the extent to which thigh intermuscular fat (IMF) and quadriceps muscle (QM) volumes explained variance in knee extensor strength and physical performance in women with radiographic knee osteoarthritis (ROA) and without. METHODS:Baseline data from 125 women (age ≥50 years) in the Osteoarthritis ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21868
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine the impact of stopping tumor necrosis factor inhibitor (TNFi) treatment on patient-reported outcomes (PROs) of physical and mental health status, health utility, pain, disability, and fatigue in patients with established rheumatoid arthritis (RA). METHODS:In the pragmatic, 12-month POET trial, 8...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23315
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Prior investigations demonstrated that autoantibodies recognizing cytosolic 5'-nucleotidase 1A (NT5C1A) are found in 33-76% of patients with inclusion body myositis (IBM) but are observed only rarely in patients with polymyositis (PM). Thus, anti-NT5C1A may help distinguish IBM from PM. Although 4-21% of pati...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22600
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate ixekizumab safety in adults with psoriatic arthritis (PsA). METHODS:Safety data from 2 integrated data sets are presented: 1) 24-week, double-blind, placebo-controlled period of SPIRIT-P1 and SPIRIT-P2; and 2) all ixekizumab-treated patients of SPIRIT-P1 and SPIRIT-P2 plus SPIRIT-P3 open-label pe...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.23738
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To study the epidemiology of hospitalized serious infections in people with gout. METHODS:We identified people with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract infection (UTI), skin and soft tissue infections (SSTI), or opportunistic infections (OI) in 1998-2016 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24201
更新日期:2020-04-05 00:00:00
abstract:OBJECTIVE:To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS:Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and methodologists generated key clinical questions to be addressed ...
journal_title:Arthritis care & research
pub_type: 杂志文章,实务指引
doi:10.1002/acr.23871
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Rheumatoid arthritis (RA) is the most common inflammatory disorder affecting the cervical spine. The purpose of this study was to characterize the atloaxial involvement with magnetic resonance imaging (MRI) in patients with early RA at the moment of diagnosis and after 18 months of a tight control therapy. M...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20573
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To evaluate pain, fatigue, and psychological functioning of childhood-onset systemic lupus erythematosus (SLE) patients and examine how these factors impact health-related quality of life (HRQOL). METHODS:At a tertiary rheumatology clinic, 60 childhood-onset SLE patients completed the following: a visual ana...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22650
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Little is known about the natural history of knee osteoarthritis (OA). We sought to identify common patterns of joint space narrowing (JSN) in well-characterized knee OA patients in the placebo arm of a 2-year international study. METHODS:We performed secondary data analyses of 622 adults ages 39-80 years in...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.20614
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oxidative stress is increased in patients with rheumatoid arthritis (RA) due to increased inflammation and contributes to the pathogenesis of atherosclerosis. METHODS:The independent association between urinary F₂-isoprostane excretion, a measure of oxidative stress, and RA was te...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20237
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:Disease activity, organ damage, and treatment burden are often substantial in children and adolescents with systemic lupus erythematous (SLE), and the complex interplay among the developing child, parents, and peers makes effective management difficult. We aimed to describe the experiences and perspectives of...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22749
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To examine the association of socioeconomic status (SES) and delays in disease-modifying antirheumatic drug (DMARD) treatment with clinical measures in rheumatoid arthritis (RA) patients. METHODS:RA patients were recruited from rheumatology practices. We assessed SES based on education, occupation, and incom...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Large database research in axial spondyloarthritis (SpA) is limited by a lack of methods for identifying most types of axial SpA. Our objective was to develop methods for identifying axial SpA concepts in the free text of documents from electronic medical records. METHODS:Veterans with documents in the natio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23140
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) is used as an anchor drug for rheumatoid arthritis (RA). Lymphoproliferative disease (LPD) occasionally develops in patients treated with MTX, and is known as MTX-associated LPD (MTX-LPD). Although MTX-LPD occurs mainly in RA patients, it has not been established if MTX administration is an...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22306
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:Prior studies have established disparities by race/ethnicity and socioeconomic status (SES) in the kind, quantity, and technical quality of systemic lupus erythematosus (SLE) care and outcomes. In this study we evaluate whether disparities exist in assessments of interactions with health care providers and he...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22427
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:Hydroxychloroquine (HCQ) has been associated with improved survival among SLE patients from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. METHODS:We conducted a nested case-control study within an incide...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24255
更新日期:2020-05-14 00:00:00
abstract:OBJECTIVE:There are no identified clinical markers that reliably predict long-term progression of interstitial lung disease (ILD) in systemic sclerosis (SSc; scleroderma). Elevated C-reactive protein (CRP) levels have been reported in SSc patients. We examined the predictive significance of CRP level for long-term ILD ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21968
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To develop and validate a short form of the Cochin Hand Function Scale (CHFS), which measures hand disability, for use in systemic sclerosis, using objective criteria and reproducible techniques. METHODS:Responses on the 18-item CHFS were obtained from English-speaking patients enrolled in the Scleroderma Pa...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22893
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To understand the impact of ankylosing spondylitis (AS) on work disability (WD) over 12 years compared with the general population, and explore factors predicting adverse work outcome, defined as new partial WD or reduction in working hours. METHODS:Source of data was the Outcome Assessments in Ankylosing Sp...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22730
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Immunosuppressive therapy may trigger hepatitis B virus (HBV) reactivation for increased morbidity and mortality. We aimed to describe HBV reactivation in patients receiving treatment for immune-mediated inflammatory diseases (IMIDs) and to evaluate a predefined algorithm for its prevention. METHODS:Physicia...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.21990
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Early detection and preemptive treatment of patients at risk is of great importance in reducing the excess risk of cardiovascular (CV) disease in rheumatoid arthritis (RA). However, it is unclear how much screening is cost-effective in RA. The objective is to assess whether CV screening in RA proves to be cos...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22929
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. METHODS:All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox pro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22991
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the feasibility and effectiveness of neuromuscular electrical stimulation (NMES) with that of high-intensity volitional resistance training for improving muscle structure and function and physical function in patients with rheumatoid arthritis (RA). We also compared pre-in...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23602
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To determine whether slower walking speed was associated with an increased risk of incident hip and knee osteoarthritis (OA)-related outcomes. METHODS:After providing informed consent, community-dwelling participants in the Johnston County Osteoarthritis Project completed 2 home-based interviews and an addit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21655
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:The Patient Health Questionnaire 9 (PHQ-9) was developed to screen for depressive disorders in community, primary care, and medical settings. We aimed to estimate its diagnostic accuracy, internal consistency, reliability, and convergent validity in diagnosing major depressive disorder (MDD) in Greek patients...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20505
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To assess the association of femoroacetabular impingement (FAI) and delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) T1 relaxation values (RVs), and to evaluate whether subtypes of FAI (cam, pincer, and mixed) are associated with region-specific dGEMRIC T1 RVs. METHODS:A populati...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23463
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between functional limitation, socioeconomic inequality, and depression in a diverse cohort of patients with rheumatoid arthritis (RA). METHODS:The study design was cross-sectional and subjects were from the University of California, San Francisco RA Cohort. Patients were enrolled...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20345
更新日期:2011-02-01 00:00:00