Hydroxychloroquine and Mortality Among Patients with Systemic Lupus Erythematosus in the General Population.

Abstract:

OBJECTIVE:Hydroxychloroquine (HCQ) has been associated with improved survival among SLE patients from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. METHODS:We conducted a nested case-control study within an incident SLE cohort from the entire population of British Columbia, Canada. Deceased cases were matched with up to three living controls by age, sex, and SLE disease duration. HCQ exposure was categorized by the time between the last HCQ prescription date covered (i.e., end of supply) and the index date (i.e., death date) as current (<30 days), recent (30-365 days), remote (>365 days), or never used. We used conditional logistic regression to assess the risk of all-cause mortality associated with current or recent HCQ exposure compared with remote HCQ users. RESULTS:Among 6,241 patients with incident SLE, we identified 290 deceased cases and 502 matched SLE controls. Adjusted odd ratios (ORs) for all-cause mortality were 0.50 (95% CI: 0.30-0.82) for current users and 2.47 (95% CI: 1.21-5.05) for recent users compared with remote users. Associations were similar in subgroups according to SLE duration (≤ 5 years vs > 5 years). CONCLUSION:Our general population data support a substantial survival benefit associated with current HCQ use. Increased mortality among patients who had discontinued HCQ recently could be due to a sick stopper effect or the loss of actual HCQ benefits.

authors

Jorge A,McCormick N,Lu N,Zheng Y,Esdaile J,De Vera M,Choi H,Avina-Zubieta JA

doi

10.1002/acr.24255

subject

Has Abstract

pub_date

2020-05-14 00:00:00

eissn

2151-464X

issn

2151-4658

pub_type

杂志文章
  • Pulmonary hypertension and other potentially fatal pulmonary complications in systemic juvenile idiopathic arthritis.

    abstract:OBJECTIVE:Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin-1 (IL-1) and IL-6 inhibitors appear to be effective treatments. Pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), and alveolar proteinosis (AP) have recently been reported ...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.21889

    authors: Kimura Y,Weiss JE,Haroldson KL,Lee T,Punaro M,Oliveira S,Rabinovich E,Riebschleger M,Antón J,Blier PR,Gerloni V,Hazen MM,Kessler E,Onel K,Passo MH,Rennebohm RM,Wallace CA,Woo P,Wulffraat N,Childhood Arthritis Rheuma

    更新日期:2013-05-01 00:00:00

  • Association of Comorbidities in Spondyloarthritis With Poor Function, Work Disability, and Quality of Life: Results From the Assessment of SpondyloArthritis International Society Comorbidities in Spondyloarthritis Study.

    abstract:OBJECTIVE:Comorbidities add to the burden of disease and its complexity, and may prevent the achievement of treat-to-target goals. The objective of this study was to study the relationship between comorbidities and key disease outcomes in spondyloarthritis (SpA), namely function, work ability, and quality of life. MET...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,多中心研究

    doi:10.1002/acr.23468

    authors: Nikiphorou E,Ramiro S,van der Heijde D,Norton S,Moltó A,Dougados M,van den Bosch F,Landewé R,Assessment of SpondyloArthritis International Society Comorbidities in Spondyloarthritis Study Task Force.

    更新日期:2018-08-01 00:00:00

  • Dyspnea assessment and pulmonary hypertension in patients with systemic sclerosis: utility of the University of California, San Diego, Shortness of Breath Questionnaire.

    abstract:OBJECTIVE:The University of California in San Diego Shortness of Breath Questionnaire (UCSD SOBQ) has been used to assess dyspnea-related activity limitation in patients with airway and parenchymal lung disease. We sought to assess the construct validity and responsiveness of the UCSD SOBQ in systemic sclerosis (SSc; s...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.21827

    authors: Chung L,Chen H,Khanna D,Steen VD

    更新日期:2013-03-01 00:00:00

  • A 4-Year-Old Child with Digital Clubbing.

    abstract::History of the present illness: A four-year-old female presented to our pediatric rheumatology clinic with chief complaint of periodic fevers and abdominal pain. Fevers began 4 months prior to presentation following a documented streptococcal pharyngeal infection, with a maximum temperature of 104F. They occurred ever...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.24428

    authors: Schultz K,Divanovic A,Towe C,Miethke A,Wusik K,Hammill A,Brunner H

    更新日期:2020-08-19 00:00:00

  • Early systemic sclerosis: analysis of the disease course in patients with marker autoantibody and/or capillaroscopic positivity.

    abstract:OBJECTIVE:To investigate whether patients affected by 1 of the 3 subsets of early systemic sclerosis (SSc; scleroderma), i.e., subset I, Raynaud's phenomenon with SSc marker autoantibodies and typical capillaroscopic findings; subset II, autoantibody positive only; and subset III, capillaroscopy positive only and not s...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,多中心研究

    doi:10.1002/acr.22304

    authors: Valentini G,Marcoccia A,Cuomo G,Vettori S,Iudici M,Bondanini F,Santoriello C,Ciani A,Cozzolino D,De Matteis GM,Cappabianca S,Vitelli F,Spanò A

    更新日期:2014-10-01 00:00:00

  • Patient Knowledge and Beliefs About Knee Osteoarthritis After Anterior Cruciate Ligament Injury and Reconstruction.

    abstract:OBJECTIVE:To explore patients' knowledge and beliefs about osteoarthritis (OA) and OA risk following anterior cruciate ligament (ACL) injury, to explore the extent to which information about these risks is provided by health professionals, and to examine associations among participant characteristics, knowledge, and ri...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.22794

    authors: Bennell KL,van Ginckel A,Kean CO,Nelligan RK,French SD,Stokes M,Pietrosimone B,Blackburn T,Batt M,Hunter DJ,Spiers L,Hinman RS

    更新日期:2016-08-01 00:00:00

  • Predictors for remission in rheumatoid arthritis patients: A systematic review.

    abstract:OBJECTIVE:To summarize the potential predictors of remission in patients with rheumatoid arthritis (RA). METHODS:We performed a systematic review of prognostic studies that identified the predictors of remission in RA patients. Studies were identified in Medline, EMBase, and the Cochrane Registry, and by hand search. ...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,评审

    doi:10.1002/acr.20188

    authors: Katchamart W,Johnson S,Lin HJ,Phumethum V,Salliot C,Bombardier C

    更新日期:2010-08-01 00:00:00

  • Predictors of health-related quality of life in children and adolescents with juvenile idiopathic arthritis: results from a Web-based survey.

    abstract:OBJECTIVE:Children with juvenile idiopathic arthritis (JIA) experience functional impairment due to joint manifestations of the disease. The aim of our present study was to assess health-related quality of life (HRQOL) and its predictors in a group of children and adolescents with JIA. METHODS:The study sample include...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.21609

    authors: Haverman L,Grootenhuis MA,van den Berg JM,van Veenendaal M,Dolman KM,Swart JF,Kuijpers TW,van Rossum MA

    更新日期:2012-05-01 00:00:00

  • Abnormal bone geometry at the metacarpal bone shaft of rheumatoid arthritis patients with maintained muscle-bone relationship.

    abstract:OBJECTIVE:Metacarpal juxtaarticular bone is altered in rheumatoid arthritis (RA). However, a detailed analysis of disease-related geometric adaptations of the metacarpal shaft is missing. The aim of the present study was to assess the role of RA disease, forearm muscle cross-sectional area (CSA), age, and sex on bone g...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.20394

    authors: Eser P,Aeberli D,Widmer J,Möller B,Villiger PM

    更新日期:2011-03-01 00:00:00

  • Atlantoepistrophic magnetic resonance imaging involvement in early rheumatoid arthritis: an aggressive tight control therapy not fully arresting the disease.

    abstract:OBJECTIVE:Rheumatoid arthritis (RA) is the most common inflammatory disorder affecting the cervical spine. The purpose of this study was to characterize the atloaxial involvement with magnetic resonance imaging (MRI) in patients with early RA at the moment of diagnosis and after 18 months of a tight control therapy. M...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.20573

    authors: Zoli A,Bosello S,Magarelli N,D'Antona G,Amelia R,Fedele A,Peluso G,Bonomo L,Ferraccioli G

    更新日期:2011-11-01 00:00:00

  • Factors explaining the discrepancy between physician and patient global assessment of joint and skin disease activity in psoriatic arthritis patients.

    abstract:OBJECTIVE:To assess the extent and determinants of discordance in scoring between patient global assessment (PtGA) and physician global assessment (PhGA) in patients with psoriatic arthritis (PsA). METHODS:A cross-sectional and longitudinal analysis of data was conducted in patients attending a large PsA clinic. The d...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.22401

    authors: Eder L,Thavaneswaran A,Chandran V,Cook R,Gladman DD

    更新日期:2015-02-01 00:00:00

  • Validation of manual muscle testing and a subset of eight muscles for adult and juvenile idiopathic inflammatory myopathies.

    abstract:OBJECTIVE:To validate manual muscle testing (MMT) for strength assessment in juvenile and adult dermatomyositis (DM) and polymyositis (PM). METHODS:Patients with PM/DM (73 children and 45 adults) were assessed at baseline and reevaluated 6-9 months later. We compared Total MMT (a group of 24 proximal, distal, and axia...

    journal_title:Arthritis care & research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/acr.20035

    authors: Rider LG,Koziol D,Giannini EH,Jain MS,Smith MR,Whitney-Mahoney K,Feldman BM,Wright SJ,Lindsley CB,Pachman LM,Villalba ML,Lovell DJ,Bowyer SL,Plotz PH,Miller FW,Hicks JE

    更新日期:2010-04-01 00:00:00

  • Performance of the assessment of quality of life measure in people with hip and knee joint disease and implications for research and clinical use.

    abstract:OBJECTIVE:To comprehensively evaluate the performance of the Assessment of Quality of Life (AQoL) instrument for measuring health-related quality of life (HRQOL) in people with hip and knee joint disease (arthritis or osteoarthritis). METHODS:Data from 237 individuals were available for analysis from a national cross-...

    journal_title:Arthritis care & research

    pub_type: 临床试验,杂志文章

    doi:10.1002/acr.22129

    authors: Ackerman IN,Busija L,Tacey MA,Bohensky MA,Ademi Z,Brand CA,Liew D

    更新日期:2014-03-01 00:00:00

  • Measuring Disease Damage and Its Severity in Childhood-Onset Systemic Lupus Erythematosus.

    abstract:OBJECTIVE:To describe the frequency and types of disease damage occurring with childhood-onset systemic lupus erythematosus (SLE) as measured by the 41-item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI's ability to reflect damage severity....

    journal_title:Arthritis care & research

    pub_type: 共识发展会议,杂志文章

    doi:10.1002/acr.23531

    authors: Holland MJ,Beresford MW,Feldman BM,Huggins J,Norambuena X,Silva CA,Susic G,Sztajnbok F,Uziel Y,Appenzeller S,Ardoin SP,Avcin T,Flores F,Goilav B,Khubchandani R,Klein-Gitelman M,Levy D,Ravelli A,Wenderfer SE,Ying J,

    更新日期:2018-11-01 00:00:00

  • Longitudinal (one-year) change in cartilage thickness in knees with early knee osteoarthritis: A within-person between-knee comparison.

    abstract::Objective: To test the hypothesis that cartilage displays significant longitudinal thickening in the external subregions of the central medial (ecMF) and lateral (ecLF) femur in knees with early radiographic osteoarthritis (ROA) compared with contralateral knees without ROA, and to explore differences in change in oth...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.22172

    authors: Cotofana S,Buck R,Dreher D,Wirth W,Roemer F,Duryea J,Nevitt M,Eckstein F,Osteoarthritis Initiative Investigators.

    更新日期:2014-04-01 00:00:00

  • Rheumatologists on the road: a subspecialist's role in caring for the homebound.

    abstract:OBJECTIVE:By 2030, the number of permanently homebound individuals in the US will increase by 50% to reach 2 million. However, no medicine subspecialty consult services exist for this rising subset of the population. This pilot program establishes a rheumatology consult service for the Mount Sinai Visiting Doctors, the...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.20539

    authors: Jain R,Dasari S,Soriano T,Decherrie L,Kerr LD

    更新日期:2011-10-01 00:00:00

  • Efficacy, Tolerability, and Safety of Cannabinoid Treatments in the Rheumatic Diseases: A Systematic Review of Randomized Controlled Trials.

    abstract:OBJECTIVE:To assess the efficacy, tolerability, and safety of cannabinoids (phyto- and syntheto-) in the management of rheumatic diseases. METHODS:Multiple databases, including Medline, Embase, and CENTRAL, were searched. Randomized controlled trials with outcomes of pain, sleep, quality of life, tolerability (dropout...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,评审

    doi:10.1002/acr.22727

    authors: Fitzcharles MA,Ste-Marie PA,Häuser W,Clauw DJ,Jamal S,Karsh J,Landry T,Leclercq S,Mcdougall JJ,Shir Y,Shojania K,Walsh Z

    更新日期:2016-05-01 00:00:00

  • Modifications in Systemic Rheumatic Disease Medications: Patients' Perspectives during the Height of the COVID-19 Pandemic in New York City.

    abstract:OBJECTIVE:Concerns about SARS-CoV-2 infection may have led to changes or discontinuation of immunosuppressive medications among patients with systemic rheumatic disease. Our goal was to assess patients' perspectives regarding medication modifications and deviations from planned uses during the height of the pandemic. ...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.24489

    authors: Mancuso CA,Duculan R,Jannat-Khah D,Barbhaiya M,Bass AR,Mandl LA,Mehta B

    更新日期:2020-10-21 00:00:00

  • 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.

    abstract:OBJECTIVE:To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS:Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and methodologists generated key clinical questions to be addressed ...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,实务指引

    doi:10.1002/acr.23871

    authors: Angeles-Han ST,Ringold S,Beukelman T,Lovell D,Cuello CA,Becker ML,Colbert RA,Feldman BM,Holland GN,Ferguson PJ,Gewanter H,Guzman J,Horonjeff J,Nigrovic PA,Ombrello MJ,Passo MH,Stoll ML,Rabinovich CE,Sen HN,Schneider

    更新日期:2019-06-01 00:00:00

  • Coping Strategies, Psychological Impact, and Support Preferences of Men With Rheumatoid Arthritis: A Multicenter Survey.

    abstract:OBJECTIVE:To investigate the existence and distribution of 2 typologies (termed "factors") of men with rheumatoid arthritis (RA) identified through our previous Q-methodology study (n = 30) in a larger sample of men with RA, and whether differences in psychosocial impact or support preferences exist between the 2 facto...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,多中心研究

    doi:10.1002/acr.23422

    authors: Flurey CA,Hewlett S,Rodham K,White A,Noddings R,Kirwan JR

    更新日期:2018-06-01 00:00:00

  • Application of Heterogeneity of Treatment Effect Methods: Exploratory Analyses of a Trial of Exercise-Based Interventions for Knee OA.

    abstract:OBJECTIVE:To evaluate heterogeneity of treatment effects (HTE) in a trial of exercise-based interventions for knee osteoarthritis (OA). METHODS:Participants (n=350) were randomized to standard physical therapy (PT; n=140), Internet-Based Exercise Training (IBET; n=142), or wait list control (WL; n=68). We applied QUal...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.24564

    authors: Coffman CJ,Arbeeva L,Schwartz TA,Callahan LF,Golightly YM,Goode AP,Huffman KM,Allen KD

    更新日期:2021-01-18 00:00:00

  • Sleep disturbances in adults with arthritis: prevalence, mediators, and subgroups at greatest risk. Data from the 2007 National Health Interview Survey.

    abstract:OBJECTIVE:To examine the prevalence of sleep disturbances in adults with arthritis in a nationally representative sample, mediators of sleep difficulties, and subgroups of individuals with arthritis at greatest risk. METHODS:Using data on US adults ages≥18 years participating in the 2007 National Health Interview Surv...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.20362

    authors: Louie GH,Tektonidou MG,Caban-Martinez AJ,Ward MM

    更新日期:2011-02-01 00:00:00

  • Treating to a target in established active rheumatoid arthritis patients receiving a tumor necrosis factor inhibitor: results from a real-world cluster-randomized adalimumab trial.

    abstract:OBJECTIVE:In early rheumatoid arthritis (RA), treating to a target is more effective than routine care (RC). Our aim was to determine if treating to a target has better outcomes than RC in established active RA. METHODS:We used a real-world, 18-month cluster-randomized trial in established active RA patients treated w...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/acr.22010

    authors: Pope JE,Haraoui B,Rampakakis E,Psaradellis E,Thorne C,Sampalis JS,Optimization of Adalimumab Trial Investigators.

    更新日期:2013-09-01 00:00:00

  • Self-Acupressure for Older Adults With Symptomatic Knee Osteoarthritis: A Randomized Controlled Trial.

    abstract:OBJECTIVE:This double-blind randomized controlled trial aimed to test the efficacy of self-administered acupressure for pain and physical function improvement for older adults with knee osteoarthritis (OA). METHODS:Participants were community-dwelling adults with symptomatic knee OA (n = 150, mean age 73 years), rando...

    journal_title:Arthritis care & research

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/acr.23262

    authors: Li LW,Harris RE,Tsodikov A,Struble L,Murphy SL

    更新日期:2018-02-01 00:00:00

  • Longitudinal Study of Fatigue, Stress, and Depression: Role of Reduction in Stress Toward Improvement in Fatigue.

    abstract:OBJECTIVE:Fatigue is common among individuals with systemic lupus erythematosus (SLE), but the causes are not well understood. Our objective was to examine perceived stress and depressive symptoms as predictors of fatigue in SLE. METHODS:Data from 2 years of the Lupus Outcomes Study (n = 650 patients), obtained throug...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.24052

    authors: Azizoddin DR,Jolly M,Arora S,Yelin E,Katz P

    更新日期:2020-10-01 00:00:00

  • The Incidence, Prevalence, and Burden of Gout in the Veterans Health Administration.

    abstract:OBJECTIVE:To determine the prevalence, incidence, and burden of gout in the Veterans Health Administration (VHA) from 2005-2014. METHODS:We used national VHA data from 1/1999-12/2014 to determine the annual incidence and prevalence of gout in the VHA. Gout burden to the VHA was determined by the proportion of patients...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.24339

    authors: Helget LN,England BR,Roul P,Sayles H,Petro AD,Michaud K,Mikuls TR

    更新日期:2020-05-31 00:00:00

  • Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and hyperuricemia: a Cross-sectional Study.

    abstract:OBJECTIVE:Although several individual nutrients/foods are associated with uric acid status, the association of overall diet quality with hyperuricemia remains unclear. We thus examined the association between adherence to the dietary approaches to stop hypertension (DASH) diet and odds of having hyperuricemia in a Chin...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.24150

    authors: Gao Y,Cui LF,Sun YY,Yang WH,Wang JR,Wu SL,Gao X

    更新日期:2020-01-21 00:00:00

  • Three-dimensional biomechanical gait characteristics at baseline are associated with progression to total knee arthroplasty.

    abstract:OBJECTIVE:To determine if baseline 3-dimensional (3-D) biomechanical gait patterns differed between those patients with moderate knee osteoarthritis (OA) who progressed to total knee arthroplasty (TKA) and those that did not, and whether these differences had predictive value. METHODS:Fifty-four patients with knee OA ...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.22564

    authors: Hatfield GL,Stanish WD,Hubley-Kozey CL

    更新日期:2015-07-01 00:00:00

  • External Validation of the Lupus Impact Tracker in a Southeastern US Longitudinal Cohort With Systemic Lupus Erythematosus.

    abstract:OBJECTIVE:To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE a...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.23009

    authors: Brandt JE,Drenkard C,Kan H,Bao G,Dunlop-Thomas C,Pobiner B,Chang DJ,Jolly M,Lim SS

    更新日期:2017-06-01 00:00:00

  • Interactions between patients, providers, and health systems and technical quality of care.

    abstract:OBJECTIVE:Prior studies have established disparities by race/ethnicity and socioeconomic status (SES) in the kind, quantity, and technical quality of systemic lupus erythematosus (SLE) care and outcomes. In this study we evaluate whether disparities exist in assessments of interactions with health care providers and he...

    journal_title:Arthritis care & research

    pub_type: 杂志文章

    doi:10.1002/acr.22427

    authors: Yelin E,Yazdany J,Tonner C,Trupin L,Criswell LA,Katz P,Schmajuk G

    更新日期:2015-03-01 00:00:00