Abstract:
OBJECTIVE:The risk of thrombotic events is elevated in patients with systemic lupus erythematosus (SLE) compared to the general population, and has been attributed to both systemic inflammation, as well as presence of antiphospholipid antibodies (aPL). We examined differences in aPL prevalence in Caucasian and African American (AA) patients with SLE and venous thromboembolic (VTE) events, and compared inflammatory markers at time of VTE event. METHODS:Records of Caucasian and AA patients with SLE and VTE events were retrieved from a Rheumatology practice based at an academic hospital. A clinically significant aPL profile was defined as anti-cardiolipin IgG/IgM and/or anti-β2 glycoprotein-I IgG/IgM ≥40 units, and/or positive lupus anticoagulant (LA) ≥1.3. Logistic regression was used to determine predictors of a clinically significant aPL profile. RESULTS:Ninety-seven patients fulfilled ACR and/or 2012 SLICC classification criteria for SLE, had history of VTE and available aPL tests (59 Caucasian and 38 AA). African Americans were 66% less likely (95% CI 0.12, 0.96; p=0.04) to have a clinically significant aPL profile compared to Caucasians in multivariable regression. Triple positivity was most frequent among Caucasians, while 7/8 AAs had a positive LA test. At time of VTE event, AAs had significantly higher levels of anti-dsDNA (p=0.02), lower hemoglobin (p=0.01), and higher erythrocyte sedimentation rate (p=0.008). CONCLUSION:Among patients with SLE and VTE events, AAs were less likely to have a clinically significant aPL profile compared to Caucasians indicating that a negative aPL profile in AA does not decrease VTE risk.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Gkrouzman E,Peng M,Davis-Porada J,Kirou KAdoi
10.1002/acr.24508subject
Has Abstractpub_date
2020-11-10 00:00:00eissn
2151-464Xissn
2151-4658pub_type
杂志文章abstract:OBJECTIVE:To investigate whether people who report both arthritis and back problems report poorer health outcomes than those who have either condition alone. METHODS:We performed an analysis of the 2005 Canadian Community Health Survey (n = 126,049, age ≥15 years). Respondents were asked about long-term chronic health...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20595
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Ankle-foot problems have a considerable impact on daily functioning in patients with hypermobile Ehlers-Danlos syndrome and Hypermobility Spectrum Disorder (hEDS/HSD). Therefore, the objective of this study is to identify alterations in multi-segment ankle and foot kinematics during gait and assessing foot fu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24526
更新日期:2020-12-04 00:00:00
abstract:OBJECTIVE:Concerns about SARS-CoV-2 infection may have led to changes or discontinuation of immunosuppressive medications among patients with systemic rheumatic disease. Our goal was to assess patients' perspectives regarding medication modifications and deviations from planned uses during the height of the pandemic. ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24489
更新日期:2020-10-21 00:00:00
abstract:OBJECTIVE:To systematically review evidence of the impact of inflammatory arthritis on, or association of inflammatory arthritis with, intimate relationships and sexual function. METHODS:Ovid Medline, Ovid PsycINFO, Ovid Embase, and EBSCO CINAHL databases were searched. Two independent reviewers selected articles, ext...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23857
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The US national prevalence of spondylarthritis (SpA) was estimated for 2 published sets of classification criteria: the Amor criteria and the European Spondylarthropathy Study Group (ESSG) criteria. These 2 SpA criteria sets have been the most widely utilized in previous population-based studies of SpA. METH...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21621
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy, tolerability, and safety of cannabinoids (phyto- and syntheto-) in the management of rheumatic diseases. METHODS:Multiple databases, including Medline, Embase, and CENTRAL, were searched. Randomized controlled trials with outcomes of pain, sleep, quality of life, tolerability (dropout...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22727
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Few data are available regarding the rates of serious adverse events (SAEs) and important medical events (IMEs) outside of product-based registries and clinical trials for juvenile idiopathic arthritis (JIA). The Enhanced Drug Safety Surveillance Project (EDSSP) was developed to pilot a novel system to collec...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22487
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To examine the association between weight change from young adulthood to midlife and risk of incident arthritis. METHODS:Using data from the National Health and Nutrition Examination Survey (NHANES), we categorized participants into weight change categories based on their recalled weight during young adultho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24252
更新日期:2020-05-06 00:00:00
abstract:OBJECTIVE:To examine clinical characteristics as possible predictors of long-term treatment continuation with adalimumab, etanercept, and infliximab in ankylosing spondylitis (AS) patients who had never taken biologics treated in clinical practice. METHODS:Patients in southern Sweden with active AS starting biologic t...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20258
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle-aged individuals with hip or knee pain. Radiographs were assigned Kellgren & Lawrence (KL) scores under different conditions at each follow-up visit for 10 years. We aimed to describe and consolidate each scoring approach, then illustrate implicatio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24563
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVE:Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash of DM without objective muscle weakness. Asian studies report that anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in CADM is associated with interstitial lung dis...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22728
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23102
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To compare the performances of 3 comorbidity indices, the Charlson Comorbidity Index, the Elixhauser Comorbidity Index, and the Centers for Medicare & Medicaid Services (CMS) risk adjustment model, Hierarchical Condition Category (HCC), in predicting post-acute discharge settings and hospital readmission for ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23195
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To validate the pediatric Patient-Reported Outcomes Measurement Information System short forms (PROMIS-SFs) in childhood-onset systemic lupus erythematosus (SLE) in a clinical setting. METHODS:At 3 study visits, childhood-onset SLE patients completed the PROMIS-SFs (anger, anxiety, depressive symptoms, fatig...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22927
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Several lines of evidence have emphasized an improvement in aerobic capacity and muscle strength after physical exercise programs in rheumatoid arthritis (RA) patients. Our objective was to evaluate the efficacy of aerobic exercises in RA on quality of life, function, and clinical and radiologic outcomes by a...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析,评审
doi:10.1002/acr.20146
更新日期:2010-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22385
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to evaluate changes in knee magnetic resonance imaging (MRI) findings over the course of 18 months in subjects with osteoarthritic change and meniscal tear treated with arthroscopic partial meniscectomy (APM) or nonoperatively with physical therapy (PT). METHODS:We used 18-mo...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23891
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:In early rheumatoid arthritis (RA), treating to a target is more effective than routine care (RC). Our aim was to determine if treating to a target has better outcomes than RC in established active RA. METHODS:We used a real-world, 18-month cluster-randomized trial in established active RA patients treated w...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22010
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To examine temporal trends in mortality rates in a large nationwide cohort of patients with end-stage renal disease (ESRD) due to granulomatosis with polyangiitis (Wegener's) (GPA-ESRD). METHODS:We identified cases of GPA-ESRD reported in the US Renal Data System between 1995 and 2014, using coding by nephro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23521
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. We investigated whether women's smoking was positively associated with SLE-associated pro-inflammatory chemokines/cytokines, [stem cell factor (SCF), B-lymphocyte stimul...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24370
更新日期:2020-07-03 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23876
更新日期:2020-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20118
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To test the validity and reliability of screening instruments for depression and anxiety in rheumatoid arthritis (RA). METHODS:Participants with RA completed the Patient Health Questionnaire (PHQ-2 or PHQ-9), the Patient Reported Outcomes Measurement Information System depression short form 8a and anxiety sh...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24011
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23009
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:By 2030, the number of permanently homebound individuals in the US will increase by 50% to reach 2 million. However, no medicine subspecialty consult services exist for this rising subset of the population. This pilot program establishes a rheumatology consult service for the Mount Sinai Visiting Doctors, the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20539
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. METHODS:Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20571
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine whether perceptions of clinical manifestations (fatigue, pain, and physical limitation) of rheumatoid arthritis (RA) differ between spouses and their partners with RA, and to determine whether the differences are associated with the perception of beneficial and problematic spousal social support....
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20330
更新日期:2011-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.22472
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To assess the relative effectiveness of combining self-management and strength training for improving functional outcomes in patients with early knee osteoarthritis. METHODS:We conducted a randomized intervention trial lasting 24 months at an academic medical center. Community-dwelling middle-aged adults (n ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.20013
更新日期:2010-01-15 00:00:00
abstract:OBJECTIVE:To compare T1ρ relaxation times of the medial and lateral regions of the patella and femoral trochlea at 6 and 12 months post-anterior cruciate ligament reconstruction (ACLR) on the ACLR and contralateral limb. Greater T1ρ relaxation times are associated with a lesser proteoglycan density of articular cartila...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24561
更新日期:2021-01-18 00:00:00