Abstract:
OBJECTIVE:Total knee replacement (TKR) is an effective treatment for end-stage knee osteoarthritis (OA). American racial minorities undergo fewer TKRs than whites. We estimated quality-adjusted life-years (QALYs) lost for African American knee OA patients due to differences in TKR offer, acceptance, and complication rates. METHODS:We used the Osteoarthritis Policy Model, a computer simulation of knee OA, to predict QALY outcomes for African American and white knee OA patients with and without TKR. We estimated per-person QALYs gained from TKR as the difference between QALYs with current TKR use and QALYs when no TKR was performed. We estimated average, per-person QALY losses in African Americans as the difference between QALYs gained with white rates of TKR and QALYs gained with African American rates of TKR. We calculated population-level QALY losses by multiplying per-person QALY losses by the number of persons with advanced knee OA. Finally, we estimated QALYs lost specifically due to lower TKR offer and acceptance rates and higher rates of complications among African American knee OA patients. RESULTS:African American men and women gain 64,100 QALYs from current TKR use. With white offer and complications rates, they would gain an additional 72,000 QALYs. Because these additional gains are unrealized, we call this a loss of 72,000 QALYs. African Americans lose 67,500 QALYs because of lower offer rates, 15,800 QALYs because of lower acceptance rates, and 2,600 QALYs because of higher complication rates. CONCLUSION:African Americans lose 72,000 QALYs due to disparities in TKR offer and complication rates. Programs to decrease disparities in TKR use are urgently needed.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Kerman HM,Smith SR,Smith KC,Collins JE,Suter LG,Katz JN,Losina Edoi
10.1002/acr.23484subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1326-1334issue
9eissn
2151-464Xissn
2151-4658journal_volume
70pub_type
杂志文章abstract:OBJECTIVE:To understand the impact of ankylosing spondylitis (AS) on work disability (WD) over 12 years compared with the general population, and explore factors predicting adverse work outcome, defined as new partial WD or reduction in working hours. METHODS:Source of data was the Outcome Assessments in Ankylosing Sp...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22730
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To study the epidemiology of hospitalized serious infections in people with gout. METHODS:We identified people with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract infection (UTI), skin and soft tissue infections (SSTI), or opportunistic infections (OI) in 1998-2016 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24201
更新日期:2020-04-05 00:00:00
abstract:OBJECTIVE:To determine the relationship between biochemical markers involved in bone turnover and bone features on imaging in knees with osteoarthritis (OA). METHODS:We analyzed data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600). Bone ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23121
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To compare the time-varying behavior of maximum toe-out angle, lateral trunk lean (over the stance leg), and pelvic obliquity (rise and drop on the swing leg) during prolonged walking in participants with and without medial compartment knee osteoarthritis (OA), and to explore correlations between these gait c...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21584
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The Veterans Affairs (VA) Rheumatoid Arthritis (VARA) registry and the VA Pharmacy Benefits Management database were linked to determine the association of methotrexate (MTX) adherence with rheumatoid arthritis (RA) disease activity. METHODS:For each patient, the medication possession ratio (MPR) was calcula...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20629
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To develop and validate a short form of the Cochin Hand Function Scale (CHFS), which measures hand disability, for use in systemic sclerosis, using objective criteria and reproducible techniques. METHODS:Responses on the 18-item CHFS were obtained from English-speaking patients enrolled in the Scleroderma Pa...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22893
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:The role of cardiovascular disease (CVD) risk factors in psoriatic arthritis (PsA) is poorly understood. We examined the prevalence of CVD risk factors at initial onset of PsA and compared the observed incidence of CVD events with that predicted by the Framingham Risk Score (FRS) to determine its applicabilit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22536
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:The efficacy and safety of subcutaneous tocilizumab (TCZ-SC) versus subcutaneous placebo (PBO-SC) was evaluated in patients with rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs in the BREVACTA study. METHODS:Patients (n = 656) were randomized 2:1 to receive TCZ-SC...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22384
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To study the risk factors for revision of primary total hip replacement (THR) in a US population-based sample. METHODS:Using Medicare claims, we identified beneficiaries from 29 US states who underwent primary THR between July 1, 1995 and June 30, 1996, with followup through December 31, 2008. Potential case...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21760
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of valgus knee bracing on pain and function, and compliance and complications, in patients with medial knee osteoarthritis (OA). METHODS:A meta-analysis of randomized controlled trials that compared changes in patient-reported pain and/or function in patients with medial knee OA was p...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.22472
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To determine whether perceptions of clinical manifestations (fatigue, pain, and physical limitation) of rheumatoid arthritis (RA) differ between spouses and their partners with RA, and to determine whether the differences are associated with the perception of beneficial and problematic spousal social support....
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20330
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To determine whether calcinosis and acro-osteolysis are related to specific nailfold videocapillaroscopy (NVC) features in patients with systemic sclerosis (SSc; scleroderma). METHODS:NVC and bilateral hand radiographs were systematically performed in 155 consecutively recruited patients with SSc during a 24...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22672
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Perceived discrimination is associated with chronic pain and depression and contributes to racial health disparities. In a cohort of older adult veterans with osteoarthritis (OA), our objective was to examine how membership in multiple socially disadvantaged groups (cumulative disadvantage) was associated wit...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.24481
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of patient gender on patient-physician communication in the process of recommendation for total knee arthroplasty (TKA). METHODS:Seventy-one physicians (38 family physicians and 33 orthopedic surgeons) in Ontario performed blinded assessments of 2 standardized patients (1 man and 1 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21970
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) predominantly affects women. Clinical phenotype and outcomes in SLE may vary by sex and are further complicated by unique concerns that are dependent upon sex-defined roles. We aimed to describe sex differences in disease-specific quality of life (QoL) assessment scores usin...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23588
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:Osteoarthritis (OA), a chronic degenerative joint disorder, is characterized by joint pain. Emerging research demonstrates that a significant number of patients evidence central sensitization (CS), a hyperexcitability in nociceptive pathways, which is known to amplify and maintain clinical pain. The clinical ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22609
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. METHODS:All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox pro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22991
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To assess experimental pain sensitivity and compare the inflammatory response to pain in 26 osteoarthritis (OA) patients and 33 age- and sex-matched controls from the general population in order to examine the nature of the association between pain and inflammation in OA. METHODS:The participants underwent p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20373
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of magnetic resonance imaging (MRI) osteoarthritis (OA) features in the patellofemoral or tibiofemoral joint (i.e., bone marrow lesions, cartilage lesions, and osteophytes) and/or functional impairments, 1 year following anterior cruciate ligament reconstruction (ACLR), can p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22761
更新日期:2016-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23210
更新日期:2017-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22306
更新日期:2014-09-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22082
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To examine the association between leisure time physical exercise, body mass index (BMI), and risk of fibromyalgia (FM). METHODS:A longitudinal study with baseline assessment of physical exercise (frequency, duration, and intensity) and BMI was used to explore the risk of having FM at 11-year followup in a l...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20118
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To examine trends in glucocorticoid (GC) use and dosing among patients diagnosed with rheumatoid arthritis (RA) over time. METHODS:A population-based inception cohort of RA patients diagnosed during 1980-2007 was followed longitudinally through their medical records until death, migration, or December 31, 20...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22365
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Metacarpal juxtaarticular bone is altered in rheumatoid arthritis (RA). However, a detailed analysis of disease-related geometric adaptations of the metacarpal shaft is missing. The aim of the present study was to assess the role of RA disease, forearm muscle cross-sectional area (CSA), age, and sex on bone g...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20394
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To validate manual muscle testing (MMT) for strength assessment in juvenile and adult dermatomyositis (DM) and polymyositis (PM). METHODS:Patients with PM/DM (73 children and 45 adults) were assessed at baseline and reevaluated 6-9 months later. We compared Total MMT (a group of 24 proximal, distal, and axia...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/acr.20035
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To explore the link between a patient acceptable symptom state (PASS) and patient-perceived impact in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS:This was a cross-sectional study of unselected patients with definite RA or PsA. Pain, functional capacity, fatigue, coping, and sleep disturb...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23176
更新日期:2017-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23772
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To compare educational and vocational outcomes among adults with childhood-onset systemic lupus erythematosus (SLE) and adult-onset SLE. METHODS:We used data derived from the 2002–2010 cycles of the Lupus Outcomes Study, a longitudinal cohort of 1,204 adult subjects with SLE. Subjects ages 18–60 years living...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22228
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. We investigated whether women's smoking was positively associated with SLE-associated pro-inflammatory chemokines/cytokines, [stem cell factor (SCF), B-lymphocyte stimul...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24370
更新日期:2020-07-03 00:00:00