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Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses.

Abstract：

BACKGROUND:Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. We investigated whether women's smoking was positively associated with SLE-associated pro-inflammatory chemokines/cytokines, [stem cell factor (SCF), B-lymphocyte stimulator (BLyS), interferon-inducible protein-10 (IP-10), interferon-alpha (IFN-α)]; or negatively associated with anti-inflammatory cytokine interleukin-10 (IL-10)]; and whether associations were modified by SLE-related autoantibody status. METHODS:The Nurses' Health Study (NHS, n=121,700) and NHSII (n=116,429) cohorts were begun in 1976 and 1989. In 1988-1990 (NHS) and 1996-1999 (NHSII), ~25% participants donated blood samples. We identified 1177 women without SLE with banked samples and tested by ELISA for chemokines/cytokines as well as anti-Sm, -Ro/SSA, La/SSB and RNP. Antinuclear antibodies (ANA) were detected by HEp-2 cell indirect immunofluorescence and anti-double-stranded DNA antibodies and were assayed by ELISA. Smoking was assessed until blood draw. Separate tobit and linear regression analyses, adjusted for potential confounders, modeled associations between smoking and log-transformed chemokine/cytokine concentrations. Analyses were stratified by autoantibody status. Effect estimates were calculated as ratios of geometric means, expressed as % differences. RESULTS:Among the 15% current/recent vs. 85% past/never smokers, BLyS levels were 8.7% higher (p<0.01), and were 24% higher (p<0.0001) among those ANA+. Current/recent smokers had IL-10 concentrations 46% lower (p<0.01) than past/never smokers; each 10 pack-years of smoking was associated with -17% IL-10 (p <0.001). Smoking was not associated with IP-10 or SCF. CONCLUSIONS:Elevated BLyS and lower IL-10 levels among current smokers, particularly among ANA+ women, may be involved in SLE pathogenesis.

journal_name

Arthritis Care Res (Hoboken)

journal_title

Arthritis care & research

authors

Hahn J,Leatherwood C,Malspeis S,Liu X,Lu B,Roberts AL,Sparks JA,Karlson EW,Feldman CH,Munroe ME,James JA,Kubzansky LD,Costenbader KH

doi

10.1002/acr.24370

subject

Has Abstract

pub_date

2020-07-03 00:00:00

eissn

2151-464X

issn

2151-4658

pub_type

杂志文章

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Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses.