Abstract:
OBJECTIVE:To evaluate the effects of valgus knee bracing on pain and function, and compliance and complications, in patients with medial knee osteoarthritis (OA). METHODS:A meta-analysis of randomized controlled trials that compared changes in patient-reported pain and/or function in patients with medial knee OA was performed. Seven databases were searched from their inception to January 2014. Two reviewers independently determined study eligibility, rated risk of bias, and extracted data. Pooled estimates and 95% confidence intervals (95% CIs) for standardized mean differences (SMDs) for the improvement in pain (and function) were calculated. Event rates (proportions) were calculated for studies that reported complications. RESULTS:Six studies were included in the meta-analysis. Overall, there was a statistically significant difference favoring the valgus brace group for improvement in pain (SMD 0.33 [95% CI 0.13, 0.52], P = 0.001) and function (SMD 0.22 [95% CI 0.02, 0.41], P = 0.03). When compared to a control group that did not use an orthosis, the effect size was moderate for pain (SMD 0.56 [95% CI 0.03, 1.09], P = 0.04) and function (SMD 0.48 [95% CI 0.02, 0.95], P = 0.04). When compared to a control group that used a control orthosis, only a small, statistically significant effect for pain remained (SMD 0.33 [95% CI 0.08, 0.58], P = 0.01). Instructions for brace use varied considerably and compliance ranged from 45% to 100%. Up to 25% of patients reported minor complications with brace use. CONCLUSION:Meta-analysis of randomized trials suggests valgus bracing for medial knee OA results in small-to-moderate improvements in pain. Effect sizes vary based on study design and warrant future research.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Moyer RF,Birmingham TB,Bryant DM,Giffin JR,Marriott KA,Leitch KMdoi
10.1002/acr.22472subject
Has Abstractpub_date
2015-04-01 00:00:00pages
493-501issue
4eissn
2151-464Xissn
2151-4658journal_volume
67pub_type
杂志文章,meta分析abstract:OBJECTIVE:We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. METHODS:All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox pro...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-11-09 00:00:00
abstract:OBJECTIVE:To study the epidemiology of hospitalized serious infections in people with gout. METHODS:We identified people with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract infection (UTI), skin and soft tissue infections (SSTI), or opportunistic infections (OI) in 1998-2016 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21874
更新日期:2013-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22172
更新日期:2014-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
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更新日期:2015-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20104
更新日期:2010-03-01 00:00:00
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journal_title:Arthritis care & research
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更新日期:2012-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:There are no identified clinical markers that reliably predict long-term progression of interstitial lung disease (ILD) in systemic sclerosis (SSc; scleroderma). Elevated C-reactive protein (CRP) levels have been reported in SSc patients. We examined the predictive significance of CRP level for long-term ILD ...
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00