Abstract:
OBJECTIVE:To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti-NXP-2) antibodies. METHODS:We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employing a keyword search strategy was performed to collect clinical and laboratory data. Anti-NXP-2 antibodies were assayed by immunoprecipitation using NXP-2 produced by in vitro transcription/translation. RESULTS:Antibodies to NXP-2 were detected in 20 of the 178 patients (11%). Anti-NXP-2 antibodies were associated with male sex (50% versus 25%; P = 0.02), dysphagia (74% versus 39%; P = 0.006), myalgia (89% versus 52%; P = 0.002), peripheral edema (35% versus 11%; P = 0.016), and calcinosis (37% versus 11%; P = 0.007). These patients were less likely to be clinically amyopathic (5% versus 23%; P = 0.08). Five of the 20 patients with anti-NXP-2 antibodies (25%) had an associated internal malignancy. No other cutaneous characteristics were associated with anti-NXP-2 antibodies, except a decreased frequency of Gottron's sign (44% versus 75%; P = 0.012) and a greater likelihood of having mild skin disease. CONCLUSION:Dermatomyositis patients with anti-NXP-2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Rogers A,Chung L,Li S,Casciola-Rosen L,Fiorentino DFdoi
10.1002/acr.23210subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1909-1914issue
12eissn
2151-464Xissn
2151-4658journal_volume
69pub_type
杂志文章abstract:OBJECTIVE:To study the epidemiology of hospitalized serious infections in people with gout. METHODS:We identified people with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract infection (UTI), skin and soft tissue infections (SSTI), or opportunistic infections (OI) in 1998-2016 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24201
更新日期:2020-04-05 00:00:00
abstract:BACKGROUND:Medication access and adherence are important determinants of health outcomes. We investigated factors associated with access and cost-related non-adherence to prescriptions in a population-based cohort of systemic lupus erythematosus (SLE) patients and controls. METHODS:Detailed sociodemographic and prescr...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-08-02 00:00:00
abstract:OBJECTIVE:Being overweight or obese is associated with many chronic diseases, but previous studies of the association with rheumatoid arthritis (RA) have shown inconsistent results. The aim of this study was to investigate the association between body mass index (BMI) and the risk of developing the 2 main subtypes of R...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21749
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the validity of different spondyloarthritis (SpA) features included in the Berlin diagnostic algorithm and the Assessment of SpondyloArthritis international Society (ASAS) classification criteria in an early SpA cohort. METHODS:This was a longitudinal multicenter study including patients from the...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23017
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To assess health-related quality of life (HRQOL) in abatacept-treated children/adolescents with juvenile idiopathic arthritis (JIA). METHODS:In this phase III, double-blind, placebo-controlled trial, subjects with active polyarticular course JIA and an inadequate response/intolerance to ≥1 disease-modifying ...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/acr.20283
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:In early rheumatoid arthritis (RA), treating to a target is more effective than routine care (RC). Our aim was to determine if treating to a target has better outcomes than RC in established active RA. METHODS:We used a real-world, 18-month cluster-randomized trial in established active RA patients treated w...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22010
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Digital ulcers represent one of the most frequent complications of systemic sclerosis (SSc; scleroderma); they are very painful, scarcely responsive to treatment, and often responsible for marked limitations on daily activities, including patient self-care. Infectious complications may severely compromise the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20673
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Differences in lipid levels associated with cardiovascular (CV) risk between rheumatoid arthritis (RA) patients and the general population remain unclear. Determining these differences is important in understanding the role of lipids in CV risk in RA. METHODS:We studied 2,005 RA subjects from 2 large academi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22091
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To describe 1) a technique that can detect synovial effusions not seen on static ultrasound (US) examination and 2) the characteristics of patients with knee osteoarthritis (OA) for whom this technique proved useful. METHODS:From reviewed records of 76 patients with knee OA (112 knees) that we had seen for U...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20047
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To examine the association of socioeconomic status (SES) and delays in disease-modifying antirheumatic drug (DMARD) treatment with clinical measures in rheumatoid arthritis (RA) patients. METHODS:RA patients were recruited from rheumatology practices. We assessed SES based on education, occupation, and incom...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23602
更新日期:2019-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20505
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23009
更新日期:2017-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22727
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash of DM without objective muscle weakness. Asian studies report that anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in CADM is associated with interstitial lung dis...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22728
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Early detection and preemptive treatment of patients at risk is of great importance in reducing the excess risk of cardiovascular (CV) disease in rheumatoid arthritis (RA). However, it is unclear how much screening is cost-effective in RA. The objective is to assess whether CV screening in RA proves to be cos...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22929
更新日期:2017-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24009
更新日期:2020-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20647
更新日期:2012-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21889
更新日期:2013-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21760
更新日期:2012-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23571
更新日期:2018-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20410
更新日期:2011-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24489
更新日期:2020-10-21 00:00:00
abstract:OBJECTIVE:To develop and pilot test a screening tool to identify cases of nephrogenic systemic fibrosis (NSF) among patients exposed to gadolinium-containing contrast agents. METHODS:Sixty English-speaking subjects were enrolled: 10 subjects diagnosed as having NSF, 10 subjects with other fibrosing skin diseases, 20 s...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.21877
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To investigate whether people who report both arthritis and back problems report poorer health outcomes than those who have either condition alone. METHODS:We performed an analysis of the 2005 Canadian Community Health Survey (n = 126,049, age ≥15 years). Respondents were asked about long-term chronic health...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20595
更新日期:2011-11-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23528
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To determine whether the effect of the Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) exercise program on hand function was mediated by changes in the proposed active ingredients: strength, dexterity, and/or range of motion. METHODS:The SARAH intervention included exercises hypothe...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23093
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of muscle strength exercise training (MSET) on lean mass (LM) gain and muscle hypertrophy in older patients with lower extremity osteoarthritis (OA). METHODS:A comprehensive search of online databases was performed on April 20, 2019. Randomized controlled trials (RCTs) that reported...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.24097
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations of diffuse idiopathic skeletal hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS:DISH and kyphosis were assessed in 1,500 men from the Osteoporotic Fractures in Men (MrOS) study and in 1,267 women from the Study of Osteoporotic Fr...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00