Abstract:
OBJECTIVE:Concerns about SARS-CoV-2 infection may have led to changes or discontinuation of immunosuppressive medications among patients with systemic rheumatic disease. Our goal was to assess patients' perspectives regarding medication modifications and deviations from planned uses during the height of the pandemic. METHODS:Adult patients of 13 rheumatologists at an academic center with physician-diagnosed rheumatic disease and prescribed disease modifying medications were interviewed by telephone and asked open-ended questions about the impact of SARS-CoV-2 on their medications. Responses were analyzed with content and thematic analyses to generate categories that described patterns of medication modification. RESULTS:112 patients (mean age 50, 86% women, 34% non-white race or Latino ethnicity) with diverse diagnoses (30% lupus, 26% rheumatoid arthritis, 44% other), taking various medications were enrolled. Patients reported clinically-relevant issues that were iteratively reviewed to generate unique categories of medication modification: medications and increased or decreased risk of SARS-CoV-2 infection; role of hydroxychloroquine; maintaining medication status quo; role of glucocorticoids; increasing or decreasing existing medications in relation to clinical disease activity; postponing infusions; and medication plan if infected by SARS-CoV-2. Some modifications were suboptimal for disease control, but were made to mitigate infection risk and to minimize potential harm when patients were unable to obtain laboratory tests and physical examinations due to cessation of in-person office visits. CONCLUSION:During the height of the pandemic, substantial medication modifications were made that, in some cases, were temporizing measures and deviations from planned regimens. Future studies will assess short- and long-term sequelae of these medication modifications.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Mancuso CA,Duculan R,Jannat-Khah D,Barbhaiya M,Bass AR,Mandl LA,Mehta Bdoi
10.1002/acr.24489subject
Has Abstractpub_date
2020-10-21 00:00:00eissn
2151-464Xissn
2151-4658pub_type
杂志文章abstract:OBJECTIVE:To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS:Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and methodologists generated key clinical questions to be addressed ...
journal_title:Arthritis care & research
pub_type: 杂志文章,实务指引
doi:10.1002/acr.23871
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To determine rates of cervical cancer screening and associated abnormal results in women with systemic lupus erythematosus (SLE). METHODS:We identified women with an initial diagnosis of SLE in the MarketScan Commercial Claims and Encounters Database from 2001 to 2014. Cervical cancer screening rates and ass...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24414
更新日期:2020-08-16 00:00:00
abstract:OBJECTIVE:In a pilot study, our group showed that an internet-based self-management program improves self-efficacy in systemic sclerosis (SSc). The objective of the current study was to compare an internet-based self-management program to a patient-focused educational book developed to assess measures of self-efficacy ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23595
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:This study was performed to determine the prevalence of elevated C-reactive protein (CRP) levels and the significance of CRP in clinical parameters in systemic sclerosis (SSc; scleroderma) patients. METHODS:Canadian Scleroderma Research Group data were used. Statistical comparisons were made for CRP levels ≤...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21716
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The role of cardiovascular disease (CVD) risk factors in psoriatic arthritis (PsA) is poorly understood. We examined the prevalence of CVD risk factors at initial onset of PsA and compared the observed incidence of CVD events with that predicted by the Framingham Risk Score (FRS) to determine its applicabilit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22536
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To assess the association of specific comorbidities with periprosthetic fractures after primary total knee replacement (TKR). METHODS:We used the prospectively collected data in the Mayo Clinic total joint registry from 1989-2008 on all patients who had undergone primary TKR. The outcome of interest was post...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20548
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To examine the association between weight change from young adulthood to midlife and risk of incident arthritis. METHODS:Using data from the National Health and Nutrition Examination Survey (NHANES), we categorized participants into weight change categories based on their recalled weight during young adultho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24252
更新日期:2020-05-06 00:00:00
abstract:OBJECTIVE:To develop a clinical risk prediction tool to identify patients most likely to experience long-term clinically meaningful functional improvement following total hip arthroplasty (THA). METHODS:We studied 282 patients from 2 health districts in England (Portsmouth and North Staffordshire) who were ≥45 years o...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21594
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To summarize the state of knowledge regarding the economic burden of systemic lupus erythematosus (SLE) and to evaluate the quality of cost-of-illness (COI) studies conducted to date. METHODS:Relevant literature was retrieved from the PubMed database in April 2010. The evaluation of identified articles was b...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20410
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Differences in lipid levels associated with cardiovascular (CV) risk between rheumatoid arthritis (RA) patients and the general population remain unclear. Determining these differences is important in understanding the role of lipids in CV risk in RA. METHODS:We studied 2,005 RA subjects from 2 large academi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22091
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Pulmonary arterial hypertension (PAH) is a rare but serious complication of systemic lupus erythematosus (SLE). Chronic hypoxia is known to cause PAH resulting from pulmonary vascular remodeling. We investigated the association between anemic hypoxia and PAH in SLE patients. METHODS:Systolic pulmonary artery...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22630
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Few data are available regarding the rates of serious adverse events (SAEs) and important medical events (IMEs) outside of product-based registries and clinical trials for juvenile idiopathic arthritis (JIA). The Enhanced Drug Safety Surveillance Project (EDSSP) was developed to pilot a novel system to collec...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22487
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Although it is common for rheumatologists to initiate biologic agents after failure of methotrexate monotherapy in rheumatoid arthritis (RA), ample data support the initial use of combinations of conventional therapies in this clinical scenario. Our study explores the durability of triple therapy (methotrexat...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23255
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To evaluate pain, fatigue, and psychological functioning of childhood-onset systemic lupus erythematosus (SLE) patients and examine how these factors impact health-related quality of life (HRQOL). METHODS:At a tertiary rheumatology clinic, 60 childhood-onset SLE patients completed the following: a visual ana...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22650
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of severe fatigue and fatigue-related limitations among adolescents with juvenile idiopathic arthritis (JIA) and other pediatric rheumatic diseases (PRDs). In addition, we assessed the effect of disease activity and pain on the severity of fatigue. METHODS:This cross-sectional stu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22710
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To examine the prevalence of sleep disturbances in adults with arthritis in a nationally representative sample, mediators of sleep difficulties, and subgroups of individuals with arthritis at greatest risk. METHODS:Using data on US adults ages≥18 years participating in the 2007 National Health Interview Surv...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20362
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA). METHODS:The Cohort Hip & Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n = 1,002) with early OA-related knee and/or hip symptoms, was follow...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20263
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To examine the differential presentation(s) of psychological and health-related outcomes in young adults with juvenile-onset fibromyalgia (FM) with and without a history of trauma, compared to healthy controls. METHODS:In total, 110 participants (86 with juvenile-onset FM and 24 healthy controls, with a mean...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23192
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To explore the link between a patient acceptable symptom state (PASS) and patient-perceived impact in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS:This was a cross-sectional study of unselected patients with definite RA or PsA. Pain, functional capacity, fatigue, coping, and sleep disturb...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23176
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Fatigue is common among individuals with systemic lupus erythematosus (SLE), but the causes are not well understood. Our objective was to examine perceived stress and depressive symptoms as predictors of fatigue in SLE. METHODS:Data from 2 years of the Lupus Outcomes Study (n = 650 patients), obtained throug...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24052
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of patient gender on patient-physician communication in the process of recommendation for total knee arthroplasty (TKA). METHODS:Seventy-one physicians (38 family physicians and 33 orthopedic surgeons) in Ontario performed blinded assessments of 2 standardized patients (1 man and 1 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21970
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To determine if low disease activity state (LDAS)/remission predicts a better health-related quality of life (HRQoL). METHODS:Patients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQoL was measured with the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24009
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:The Psoriatic Arthritis Disease Activity Score (PASDAS) is a composite measure of psoriatic arthritis (PsA) disease activity. The length of its patient-reported components raises concern about questionnaire burden. The PASDAS includes the Medical Outcomes Study Short Form 36 (SF-36) health survey. We undertoo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23876
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To examine cross-sectionally whether intraabdominal fat area (IAFA), i.e., visceral fat, and liver fat assessed by computed tomography (CT) are independently associated with hyperuricemia. METHODS:Subjects were 801 Japanese men not taking antidiabetic, antihypertensive, or urate-lowering medications, without...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22729
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To assess the extent and determinants of discordance in scoring between patient global assessment (PtGA) and physician global assessment (PhGA) in patients with psoriatic arthritis (PsA). METHODS:A cross-sectional and longitudinal analysis of data was conducted in patients attending a large PsA clinic. The d...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22401
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine the sensitivity of the new 2013 classification criteria for systemic sclerosis (SSc; scleroderma) in an independent cohort of SSc subjects and to assess the contribution of individual items of the criteria to the overall sensitivity. METHODS:SSc subjects from the Canad...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22451
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To develop and pilot test a screening tool to identify cases of nephrogenic systemic fibrosis (NSF) among patients exposed to gadolinium-containing contrast agents. METHODS:Sixty English-speaking subjects were enrolled: 10 subjects diagnosed as having NSF, 10 subjects with other fibrosing skin diseases, 20 s...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.21877
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Although several individual nutrients/foods are associated with uric acid status, the association of overall diet quality with hyperuricemia remains unclear. We thus examined the association between adherence to the dietary approaches to stop hypertension (DASH) diet and odds of having hyperuricemia in a Chin...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24150
更新日期:2020-01-21 00:00:00
abstract:OBJECTIVE:To study how corticosteroid therapy is planned and described in reports of systemic disease trials and estimate the impact of the between-arm difference in corticosteroid dose on treatment effect. METHODS:We performed a systematic review of PubMed and Cochrane databases on all reports of randomized systemic ...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20139
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the short-term and long-term impact of a centralized system for the intake and triage of rheumatology referrals on access to care and referral quality. METHODS:An innovative central referral process, the Central Referral and Triage in Rheumatology (CReATe Rheum) program, was implemented in 2006, ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22845
更新日期:2016-10-01 00:00:00