Abstract:
OBJECTIVE:To compare educational and vocational outcomes among adults with childhood-onset systemic lupus erythematosus (SLE) and adult-onset SLE. METHODS:We used data derived from the 2002–2010 cycles of the Lupus Outcomes Study, a longitudinal cohort of 1,204 adult subjects with SLE. Subjects ages 18–60 years living in the US (n = 929) were included in the analysis and were classified as childhood-onset SLE if age at diagnosis was <18 years (n = 115). Logistic regression was used to assess the unadjusted and adjusted effect of childhood-onset SLE, sex, race/ethnicity, baseline age, urban or rural location, and US region on the likelihood of completing a bachelor's degree. Generalized estimating equations were used to assess the effect of childhood-onset SLE, demographics, education, and disease-related factors on the odds of employment, accounting for multiple observations over the study period. RESULTS:Subjects with childhood-onset SLE were on average younger (mean ± SD 29 ± 10 years versus 44 ± 9 years), with longer disease duration (mean ± SD 15 ± 10 years versus 11 ± 8 years). Subjects with adult-onset SLE and childhood-onset SLE subjects were equally likely to complete a bachelor's degree. However, subjects with childhood-onset SLE were significantly less likely to be employed, independent of demographic and disease characteristics (odds ratio 0.62, 95% confidence interval 0.42–0.91). CONCLUSION:While subjects with SLE are just as likely as those with adult-onset SLE to complete college education, childhood-onset SLE significantly increases the risk of not working in adulthood, even when controlling for disease and demographic factors. Exploring reasons for low rates of employment and providing vocational support may be important to maximize long-term functional outcomes in patients with childhood-onset SLE.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Lawson EF,Hersh AO,Trupin L,von Scheven E,Okumura MJ,Yazdany J,Yelin EHdoi
10.1002/acr.22228subject
Has Abstractpub_date
2014-05-01 00:00:00pages
717-24issue
5eissn
2151-464Xissn
2151-4658journal_volume
66pub_type
杂志文章abstract:OBJECTIVE:To examine cross-sectionally whether intraabdominal fat area (IAFA), i.e., visceral fat, and liver fat assessed by computed tomography (CT) are independently associated with hyperuricemia. METHODS:Subjects were 801 Japanese men not taking antidiabetic, antihypertensive, or urate-lowering medications, without...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22729
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To describe the frequency and types of disease damage occurring with childhood-onset systemic lupus erythematosus (SLE) as measured by the 41-item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI's ability to reflect damage severity....
journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
doi:10.1002/acr.23531
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Few data are available regarding the rates of serious adverse events (SAEs) and important medical events (IMEs) outside of product-based registries and clinical trials for juvenile idiopathic arthritis (JIA). The Enhanced Drug Safety Surveillance Project (EDSSP) was developed to pilot a novel system to collec...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22487
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Telemedicine is increasingly being offered to patients for rheumatology care, but few studies have examined factors associated with telemedicine use or outcomes of telemedicine in rheumatology. The objective of this analysis was to determine factors associated with the use of video telemedicine when offered a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24049
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:A lack of agreement between clinician and patient priorities can impact the clinician-patient relationship, treatment concordance, and potential health outcomes. Studies have suggested that patients with osteoarthritis (OA) may prioritize comorbidities over their OA, but as yet no explicit systematic explorat...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21897
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases. METHODS:This was a cross-sectional multicenter study where the prevalence of more relevant comorbiditie...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23015
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To investigate the response of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) by ultrasonographic evaluation of changes in the wrist and hand, and to determine whether such assessments during early TCZ treatment predict later clinical outcome. METHODS:Thirty-two RA patients about to receive TCZ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20537
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To develop a clinical risk prediction tool to identify patients most likely to experience long-term clinically meaningful functional improvement following total hip arthroplasty (THA). METHODS:We studied 282 patients from 2 health districts in England (Portsmouth and North Staffordshire) who were ≥45 years o...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21594
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Childhood scleroderma encompasses a rare, poorly understood spectrum of conditions. Our aim was to ascertain the incidence of childhood scleroderma in its different forms in the UK and Ireland, and to describe the age, sex, and ethnicity of the cases. METHODS:The members of 5 specialist medical associations ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20070
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Osteoarthritis (OA), a chronic degenerative joint disorder, is characterized by joint pain. Emerging research demonstrates that a significant number of patients evidence central sensitization (CS), a hyperexcitability in nociceptive pathways, which is known to amplify and maintain clinical pain. The clinical ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22609
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA). METHODS:This was an assessor-blinded, 3-arm randomized controlled trial in 22...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22744
更新日期:2016-05-01 00:00:00
abstract::In this issue of AC&R, Hauser et. al. compare the prevalence of fibromyalgia (FM) in a German population using the 2016 Modified ACR criteria to the prevalence using the new ACTTION-APS Pain Taxonomy (AAPT) criteria. ...
journal_title:Arthritis care & research
pub_type: 社论
doi:10.1002/acr.24198
更新日期:2020-04-05 00:00:00
abstract:OBJECTIVE:To determine factors that are predictive of incident, recurrent, or resolved shoulder pain in a community-based sample from the general population. METHODS:This study used data from the North West Adelaide Health Study, a cohort study located in the northwestern suburbs of Adelaide, South Australia. Data wer...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22082
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To determine whether calcinosis and acro-osteolysis are related to specific nailfold videocapillaroscopy (NVC) features in patients with systemic sclerosis (SSc; scleroderma). METHODS:NVC and bilateral hand radiographs were systematically performed in 155 consecutively recruited patients with SSc during a 24...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22672
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations of diffuse idiopathic skeletal hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS:DISH and kyphosis were assessed in 1,500 men from the Osteoporotic Fractures in Men (MrOS) study and in 1,267 women from the Study of Osteoporotic Fr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23115
更新日期:2017-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22010
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin-1 (IL-1) and IL-6 inhibitors appear to be effective treatments. Pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), and alveolar proteinosis (AP) have recently been reported ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21889
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the short-term and long-term impact of a centralized system for the intake and triage of rheumatology referrals on access to care and referral quality. METHODS:An innovative central referral process, the Central Referral and Triage in Rheumatology (CReATe Rheum) program, was implemented in 2006, ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22845
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To validate a magnetic resonance imaging (MRI) reference criterion for a positive sacroiliac (SI) joint MRI finding based on the level of confidence in the classification of spondyloarthritis (SpA) by expert MRI readers. METHODS:Four readers assessed SI joint MRIs in 2 inception cohorts (cohorts A and B) of ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21893
更新日期:2013-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23602
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti-NXP-2) antibodies. METHODS:We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employin...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23210
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To review the performance characteristics of the instruments most commonly used to measure clinical outcomes in juvenile idiopathic arthritis (JIA), including global assessments, articular indices, functional/disability assessments, and quality of life measures. METHODS:As part of an Agency for Healthcare Re...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20667
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We compared patient-reported outcomes (PROs) in patients with RA treated with tofacitinib or placebo in combination with conventional disease-modifying antirheumatic drugs (DMARDs). METHODS:In a 12-month, phase III ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23004
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To determine the risk of sick leave and work disability in relation to rheumatic diseases and cardiovascular comorbidities among working individuals. METHODS:Employees (n = 12,140) from 45 companies in The Netherlands were prospectively followed up from 1998-2008. Questionnaires were used to assess self-repo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22095
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To validate manual muscle testing (MMT) for strength assessment in juvenile and adult dermatomyositis (DM) and polymyositis (PM). METHODS:Patients with PM/DM (73 children and 45 adults) were assessed at baseline and reevaluated 6-9 months later. We compared Total MMT (a group of 24 proximal, distal, and axia...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/acr.20035
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To determine the extent to which thigh intermuscular fat (IMF) and quadriceps muscle (QM) volumes explained variance in knee extensor strength and physical performance in women with radiographic knee osteoarthritis (ROA) and without. METHODS:Baseline data from 125 women (age ≥50 years) in the Osteoarthritis ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21868
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Early detection and preemptive treatment of patients at risk is of great importance in reducing the excess risk of cardiovascular (CV) disease in rheumatoid arthritis (RA). However, it is unclear how much screening is cost-effective in RA. The objective is to assess whether CV screening in RA proves to be cos...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22929
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:Total knee replacement (TKR) is an effective treatment for end-stage knee osteoarthritis (OA). American racial minorities undergo fewer TKRs than whites. We estimated quality-adjusted life-years (QALYs) lost for African American knee OA patients due to differences in TKR offer, acceptance, and complication ra...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23484
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between functional limitation, socioeconomic inequality, and depression in a diverse cohort of patients with rheumatoid arthritis (RA). METHODS:The study design was cross-sectional and subjects were from the University of California, San Francisco RA Cohort. Patients were enrolled...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20345
更新日期:2011-02-01 00:00:00