Abstract:
OBJECTIVE:To compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases. METHODS:This was a cross-sectional multicenter study where the prevalence of more relevant comorbidities in 2 cohorts was compared. Patients under followup from SJOGRENSER (Spanish Rheumatology Society Registry of Primary SS) and RELESSER (Spanish Rheumatology Society Registry of SLE), and who fulfilled the 2002 American-European Consensus Group and 1997 American College of Rheumatology classification criteria, respectively, were included. A binomial logistic regression analysis was carried out to explore potential differences, making general adjustments for age, sex, and disease duration and specific adjustments for each variable, including CV risk factors and treatments, when appropriate. RESULTS:A total of 437 primary SS patients (95% female) and 2,926 SLE patients (89% female) were included. The mean age was 58.6 years (interquartile range [IQR] 50.0-69.9 years) for primary SS patients and 45.1 years (IQR 36.4-56.3 years) for SLE patients (P < 0.001), and disease duration was 10.4 years (IQR 6.0-16.7 years) and 13.0 years (IQR 7.45-19.76 years), respectively (P < 0.001). Smoking, dyslipidemia, and arterial hypertension were associated less frequently with primary SS (odds ratio [OR] 0.36 [95% confidence interval (95% CI) 0.28-0.48], 0.74 [95% CI 0.58-0.94], and 0.50 [95% CI 0.38-0.66], respectively) as were life-threatening CV events (i.e., stroke or myocardial infarction; OR 0.57 [95% CI 0.35-0.92]). Conversely, lymphoma was associated more frequently with primary SS (OR 4.41 [95% CI 1.35-14.43]). The prevalence of severe infection was lower in primary SS than in SLE (10.1% versus 16.9%; OR 0.54 [95% CI 0.39-0.76]; P < 0.001). CONCLUSION:Primary SS patients have a consistently less serious CV comorbidity burden and a lower prevalence of severe infection than those with SLE. In contrast, their risk of lymphoma is greater.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Rúa-Figueroa I,Fernández Castro M,Andreu JL,Sanchez-Piedra C,Martínez-Taboada V,Olivé A,López-Longo J,Rosas J,Galindo M,Calvo-Alén J,Fernández-Nebro A,Alonso F,Rodríguez-Lozano B,Alberto García Vadillo J,Menor R,Narváez FJdoi
10.1002/acr.23015subject
Has Abstractpub_date
2017-01-01 00:00:00pages
38-45issue
1eissn
2151-464Xissn
2151-4658journal_volume
69pub_type
杂志文章,多中心研究abstract:OBJECTIVE:Since 2014, rheumatology fellows have been assessed not only based on their ability to provide patient care and possess medical knowledge but also on their skill in serving as patient advocates, navigators of health systems, and members of a health care team. Such assessments have been carried out through the...
journal_title:Arthritis care & research
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journal_title:Arthritis care & research
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2010-01-15 00:00:00
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更新日期:2011-02-01 00:00:00
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更新日期:2020-01-21 00:00:00
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更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-09-01 00:00:00
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更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章,meta分析,多中心研究
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更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章,评审
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