Abstract:
OBJECTIVE:To assess the association of specific comorbidities with periprosthetic fractures after primary total knee replacement (TKR). METHODS:We used the prospectively collected data in the Mayo Clinic total joint registry from 1989-2008 on all patients who had undergone primary TKR. The outcome of interest was postoperative periprosthetic fractures during followup. The main predictors of interest were comorbidities grouped from the validated Deyo-Charlson index. Multivariable-adjusted Cox regression analyses were adjusted for sex, age, body mass index (BMI), American Society of Anesthesiology (ASA) class, operative diagnosis, and implant fixation. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated. RESULTS:We included 17,633 primary TKRs with a mean followup of 6.3 years. The mean age was 68 years, 55% were women, and the mean BMI was 31 kg/m(2) . There were 188 postoperative periprosthetic fractures on postoperative day 1 or later; 162 fractures (86%) occurred on postoperative day 90 or later. In multivariable analyses that simultaneously adjusted for all comorbidities and other variables (age, sex, BMI, ASA, operative diagnosis, and cement status), the following 2 conditions were significantly associated with an increased hazard of postoperative periprosthetic fractures: peptic ulcer disease (HR 1.87, 95% CI 1.28-2.75; P = 0.0014) and chronic obstructive pulmonary disease (HR 1.62, 95% CI 1.10-2.40; P = 0.02). CONCLUSION:Peptic ulcer disease and chronic obstructive pulmonary disease are associated with a higher risk of periprosthetic fractures after primary TKR. This may be related to the disease or its treatments, which need further study. Identification of specific risk factors may allow for implementation of intervention strategies to reduce this risk.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Singh JA,Lewallen DGdoi
10.1002/acr.20548subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1471-6issue
10eissn
2151-464Xissn
2151-4658journal_volume
63pub_type
杂志文章abstract:OBJECTIVE:To determine the influence of socioeconomic factors on disease activity in a Latin American (LA) early rheumatoid arthritis (RA) multinational inception cohort at baseline. METHODS:Clinical evaluation, ethnicity, socioeconomic status (SES), 4-variable Disease Activity Score in 28 joints using the erythrocyte...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21680
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To determine the clinical manifestations and disease damage associated with discoid rash in a large multiethnic systemic lupus erythematosus (SLE) cohort. METHODS:SLE patients (per American College of Rheumatology [ACR] criteria) ages ≥16 years with a disease duration of ≤10 years at enrollment and defined e...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21581
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23285
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Several lines of evidence have emphasized an improvement in aerobic capacity and muscle strength after physical exercise programs in rheumatoid arthritis (RA) patients. Our objective was to evaluate the efficacy of aerobic exercises in RA on quality of life, function, and clinical and radiologic outcomes by a...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析,评审
doi:10.1002/acr.20146
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Cognitive function may change over time in patients with SLE, and cognitive function trajectories have not well been studied. We aim to: 1) identify cognitive function trajectories in SLE and describe it with depressive symptoms trajectories and 2) identify baseline factors associated with class membership i...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24349
更新日期:2020-06-11 00:00:00
abstract:OBJECTIVE:Several current and many emerging osteoarthritis (OA) treatments are intra-articular (IA) injections. However, little is known about physicians' perceptions and beliefs regarding IA injections or their considerations when deciding whether to recommend them to patients. We aimed to investigate physician-percei...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24502
更新日期:2020-11-09 00:00:00
abstract:OBJECTIVE:Cachexia is a disorder characterized by involuntary weight loss in addition to loss of homeostatic control of both energy and protein balance. Despite an abundance of data from other inflammatory diseases, cachexia in SLE remains a largely undescribed syndrome. METHODS:2406 patients in a prospective SLE coho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24395
更新日期:2020-08-02 00:00:00
abstract:OBJECTIVE:To assess the extent and determinants of discordance in scoring between patient global assessment (PtGA) and physician global assessment (PhGA) in patients with psoriatic arthritis (PsA). METHODS:A cross-sectional and longitudinal analysis of data was conducted in patients attending a large PsA clinic. The d...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22401
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To determine the occurrence of traditional cardiovascular (CV) risk factors and coronary artery calcification (CAC) in adults with polymyositis (PM) or dermatomyositis (DM) compared to healthy controls and to assess the association between CV risk factors, PM/DM, and CAC score. METHODS:Traditional CV risk fa...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22520
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To investigate the existence and distribution of 2 typologies (termed "factors") of men with rheumatoid arthritis (RA) identified through our previous Q-methodology study (n = 30) in a larger sample of men with RA, and whether differences in psychosocial impact or support preferences exist between the 2 facto...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23422
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To determine whether amount of physical activity (PA) is a determinant of joint space narrowing (JSN) worsening over 48-months in participants with knee osteoarthritis (OA). METHODS:Data were obtained from the Osteoarthritis Initiative. PA, measured using the Physical Activity Scale for the Elderly (PASE), w...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24554
更新日期:2021-01-07 00:00:00
abstract:OBJECTIVE:Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23102
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations of diffuse idiopathic skeletal hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS:DISH and kyphosis were assessed in 1,500 men from the Osteoporotic Fractures in Men (MrOS) study and in 1,267 women from the Study of Osteoporotic Fr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23115
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Joint replacement surgery is a proxy of severe joint damage in rheumatoid arthritis (RA). The aim of this study was to assess the impact of the introduction of biologic disease-modifying antirheumatic drugs (bDMARDs) on the incidence rate (IR) of upper limb joint replacements among newly diagnosed RA patients...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23835
更新日期:2020-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22147
更新日期:2014-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/acr.20035
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:The Patient Health Questionnaire 9 (PHQ-9) was developed to screen for depressive disorders in community, primary care, and medical settings. We aimed to estimate its diagnostic accuracy, internal consistency, reliability, and convergent validity in diagnosing major depressive disorder (MDD) in Greek patients...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20505
更新日期:2011-09-01 00:00:00
abstract::The illness started with pain and stiffness in her bilateral hands and wrists four months prior, with progression to bilateral elbows, knees, and ankles. The pain and stiffness were worse in the morning and limited her ability to use her hands or walk comfortably. She also noted swelling of her hands, knees, and ankle...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24141
更新日期:2020-01-21 00:00:00
abstract:OBJECTIVE:Milk consumption has long been recognized for its important role in bone health, but its role in the progression of knee osteoarthritis (OA) is unclear. We examined the prospective association of milk consumption with radiographic progression of knee OA. METHODS:In the Osteoarthritis Initiative, 2,148 partic...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22297
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To describe the frequency and types of disease damage occurring with childhood-onset systemic lupus erythematosus (SLE) as measured by the 41-item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI's ability to reflect damage severity....
journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
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更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability. METHODS:Subjects included 898 older persons from the Rush Memory and Aging Project without dementia, stroke, or Parkinson's disease at baseline. All participants underwent detailed baseline eva...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20200
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA). METHODS:The Cohort Hip & Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n = 1,002) with early OA-related knee and/or hip symptoms, was follow...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20263
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:The Veterans Affairs (VA) Rheumatoid Arthritis (VARA) registry and the VA Pharmacy Benefits Management database were linked to determine the association of methotrexate (MTX) adherence with rheumatoid arthritis (RA) disease activity. METHODS:For each patient, the medication possession ratio (MPR) was calcula...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20629
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle-aged individuals with hip or knee pain. Radiographs were assigned Kellgren & Lawrence (KL) scores under different conditions at each follow-up visit for 10 years. We aimed to describe and consolidate each scoring approach, then illustrate implicatio...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24563
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVE:A recent study conducted by our clinical group demonstrated that low disease activity (LDA), defined as a clinical Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score ≤2, maintained for 12 months, confers the same risk for damage accrual as complete remission after 2 years. The aim of t...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23720
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The RhoA/Rho kinase pathway plays a pivotal role in cold-induced vasoconstriction, vascular smooth muscle cells function, and vascular homeostasis. This study evaluates the efficacy of fasudil, a RhoA/Rho kinase inhibitor, to reverse cold-induced vasospasm in patients with Raynaud's phenomenon (RP) secondary ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21622
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The risk of thrombotic events is elevated in patients with systemic lupus erythematosus (SLE) compared to the general population, and has been attributed to both systemic inflammation, as well as presence of antiphospholipid antibodies (aPL). We examined differences in aPL prevalence in Caucasian and African ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24508
更新日期:2020-11-10 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24049
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of a 12-session walking skill training program of weight-bearing activities on physical functioning and self-efficacy initiated in patients 3 months after total hip arthroplasty (THA). METHODS:Sixty-eight patients with THA, 35 women and 33 men, with a mean age of 66 years (95% confi...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.20681
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To determine the extent to which demographic and geographic disparities exist in the use of post-acute rehabilitation care (PARC) for joint replacement. METHODS:We conducted a cross-sectional analysis of 2 years (2005 and 2006) of population-based hospital discharge data from 392 hospitals in 4 states (Arizo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20477
更新日期:2011-07-01 00:00:00