Abstract:
OBJECTIVE:A recent study conducted by our clinical group demonstrated that low disease activity (LDA), defined as a clinical Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score ≤2, maintained for 12 months, confers the same risk for damage accrual as complete remission after 2 years. The aim of the present study was to assess the validity of these findings in the long term (10 years). METHODS:Patients in the inception cohort of the Toronto Lupus Clinic, who had a minimum follow-up of 10 years and no interval >18 months between consecutive visits, were included in the analysis. Prolonged clinical remission was defined based on a SLEDAI-2K score of 0 (serology excluded), achieved within the first 5 years of enrollment and maintained for ≥10 years. Prolonged LDA was defined as SLEDAI-2K score ≤2 (serology excluded) with the same time frame restrictions. RESULTS:Of 267 patients, 27 (10.1%) achieved prolonged clinical remission and 48 (18%) attained prolonged LDA. There were no differences regarding demographic, clinical, and immunologic variables at any time. The mean prednisone dose at enrollment was higher in patients in whom remission was achieved, while patients with prolonged LDA were taking antimalarials more frequently, both at enrollment and after the 10-year time period. Cumulative damage and flare rate after 10 years, and mortality throughout follow-up were comparable. SLE in patients in the prolonged LDA group was in complete remission for 76% of the follow-up time. CONCLUSION:Prolonged clinical remission and LDA were demonstrated in 10.1% and 18% of our patients, respectively, and comparable outcomes were demonstrated in the long term, rendering sustained LDA an acceptable treat-to-target outcome in SLE.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Tselios K,Gladman DD,Touma Z,Su J,Anderson N,Urowitz MBdoi
10.1002/acr.23720subject
Has Abstractpub_date
2019-06-01 00:00:00pages
822-828issue
6eissn
2151-464Xissn
2151-4658journal_volume
71pub_type
杂志文章abstract:OBJECTIVE:We propose new classification criteria for Sjögren's syndrome (SS), which are needed considering the emergence of biologic agents as potential treatments and their associated comorbidity. These criteria target individuals with signs/symptoms suggestive of SS. METHODS:Criteria are based on expert opinion elic...
journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
doi:10.1002/acr.21591
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between biochemical markers involved in bone turnover and bone features on imaging in knees with osteoarthritis (OA). METHODS:We analyzed data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600). Bone ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23121
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To determine whether a decline in walking speed during the year prior to disease onset is associated with concurrent changes in cartilage, bone marrow lesions (BMLs), or effusion in adults who develop common knee osteoarthritis (OA), accelerated knee OA, or no knee OA. METHODS:We identified 3 groups from the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23613
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) has been linked to functional disability and increased risk of falls, but mechanisms underpinning functional disability are unclear. This study investigated functional performance, muscle strength, and plantar pressures in adults with mild, moderate, and severe HV compared to controls, whil...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22380
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin-1 (IL-1) and IL-6 inhibitors appear to be effective treatments. Pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), and alveolar proteinosis (AP) have recently been reported ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21889
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To investigate physical therapists' knowledge, beliefs, and current practices around falls prevention in osteoarthritis (OA) care. METHODS:Currently registered, practicing Australian physical therapists who care for patients with hip and/or knee OA were invited to participate in this cross-sectional study. A...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23996
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Illness behaviors (cognitive, affective, and behavioral reactions) among individuals with systemic sclerosis (SSc; scleroderma) are of clinical concern due to relationships between these behaviors and physical and mental quality of life, such as pain and symptoms of depression. Self-report measures with good ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21874
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oxidative stress is increased in patients with rheumatoid arthritis (RA) due to increased inflammation and contributes to the pathogenesis of atherosclerosis. METHODS:The independent association between urinary F₂-isoprostane excretion, a measure of oxidative stress, and RA was te...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20237
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To assess experimental pain sensitivity and compare the inflammatory response to pain in 26 osteoarthritis (OA) patients and 33 age- and sex-matched controls from the general population in order to examine the nature of the association between pain and inflammation in OA. METHODS:The participants underwent p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20373
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To review the performance characteristics of the instruments most commonly used to measure clinical outcomes in juvenile idiopathic arthritis (JIA), including global assessments, articular indices, functional/disability assessments, and quality of life measures. METHODS:As part of an Agency for Healthcare Re...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20667
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy, tolerability, and safety of cannabinoids (phyto- and syntheto-) in the management of rheumatic diseases. METHODS:Multiple databases, including Medline, Embase, and CENTRAL, were searched. Randomized controlled trials with outcomes of pain, sleep, quality of life, tolerability (dropout...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22727
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To identify a combination of clinical factors associated with low disease activity and remission in the third trimester during pregnancy in women with rheumatoid arthritis (RA). METHODS:This study is embedded in the Pregnancy-Induced Amelioration of Rheumatoid Arthritis study, a prospective cohort study. The...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23143
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of magnetic resonance imaging (MRI) osteoarthritis (OA) features in the patellofemoral or tibiofemoral joint (i.e., bone marrow lesions, cartilage lesions, and osteophytes) and/or functional impairments, 1 year following anterior cruciate ligament reconstruction (ACLR), can p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22761
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To evaluate pain, fatigue, and psychological functioning of childhood-onset systemic lupus erythematosus (SLE) patients and examine how these factors impact health-related quality of life (HRQOL). METHODS:At a tertiary rheumatology clinic, 60 childhood-onset SLE patients completed the following: a visual ana...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22650
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Married persons have, on average, better mental health than nonmarried persons. Among married persons, marital satisfaction is associated with better mental health. Studies on mental health in married and nonmarried persons that consider marital satisfaction have categorized patients as satisfied versus unsat...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22802
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:Competent examination of the pediatric musculoskeletal (MSK) system is a vital component of clinical assessment of children with MSK presentations. The aim was to develop a regional MSK examination for school-age children that is age appropriate and reflects clinical practice. METHODS:Qualitative and quantit...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20569
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:In a pilot study, our group showed that an internet-based self-management program improves self-efficacy in systemic sclerosis (SSc). The objective of the current study was to compare an internet-based self-management program to a patient-focused educational book developed to assess measures of self-efficacy ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23595
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to evaluate changes in knee magnetic resonance imaging (MRI) findings over the course of 18 months in subjects with osteoarthritic change and meniscal tear treated with arthroscopic partial meniscectomy (APM) or nonoperatively with physical therapy (PT). METHODS:We used 18-mo...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23891
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The influence of specific medications on the risk of postoperative infection in patients with rheumatoid arthritis and other inflammatory rheumatic diseases (IRDs) remains unclear. This retrospective study examined the risk of postoperative infection at the site of surgery in patients treated with immunosuppr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22077
更新日期:2013-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22749
更新日期:2016-06-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24255
更新日期:2020-05-14 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23165
更新日期:2017-11-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22559
更新日期:2015-08-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23857
更新日期:2020-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24118
更新日期:2019-11-30 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23876
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To investigate whether patients affected by 1 of the 3 subsets of early systemic sclerosis (SSc; scleroderma), i.e., subset I, Raynaud's phenomenon with SSc marker autoantibodies and typical capillaroscopic findings; subset II, autoantibody positive only; and subset III, capillaroscopy positive only and not s...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22304
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Rheumatoid arthritis (RA) is the most common inflammatory disorder affecting the cervical spine. The purpose of this study was to characterize the atloaxial involvement with magnetic resonance imaging (MRI) in patients with early RA at the moment of diagnosis and after 18 months of a tight control therapy. M...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20573
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine the impact of stopping tumor necrosis factor inhibitor (TNFi) treatment on patient-reported outcomes (PROs) of physical and mental health status, health utility, pain, disability, and fatigue in patients with established rheumatoid arthritis (RA). METHODS:In the pragmatic, 12-month POET trial, 8...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23315
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To describe the effect of different exposure classification strategies for disease-modifying antirheumatic drugs (DMARDs) on drug-outcome associations. METHODS:We studied the association between DMARD initiation and all-cause hospitalizations in patients with rheumatoid arthritis (RA), 1995-2005. Initiators ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20087
更新日期:2010-05-01 00:00:00