Abstract:
OBJECTIVE:To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. METHODS:Archive data from the UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from -5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease-related factors, and symptoms of pain, fatigue, anxiety, and depression. RESULTS:Patients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness -0.42 ± 2.2 and -1.24 ± 1.6 oral dryness). Twenty-seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self-reported pain and that of oral dryness sensitivity to be self-reported fatigue. CONCLUSION:Ocular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögren's syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Bezzina OM,Gallagher P,Mitchell S,Bowman SJ,Griffiths B,Hindmarsh V,Hargreaves B,Price EJ,Pease CT,Emery P,Lanyon P,Bombardieri M,Sutcliffe N,Pitzalis C,Hunter J,Gupta M,McLaren J,Cooper AM,Regan M,Giles IP,Isenbedoi
10.1002/acr.23165subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1714-1723issue
11eissn
2151-464Xissn
2151-4658journal_volume
69pub_type
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journal_title:Arthritis care & research
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journal_title:Arthritis care & research
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journal_title:Arthritis care & research
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2020-08-02 00:00:00
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