Abstract:
OBJECTIVE:Although it is common for rheumatologists to initiate biologic agents after failure of methotrexate monotherapy in rheumatoid arthritis (RA), ample data support the initial use of combinations of conventional therapies in this clinical scenario. Our study explores the durability of triple therapy (methotrexate, sulfasalazine, and hydroxychloroquine) versus methotrexate-etanercept in RA. METHODS:RA patients with suboptimal response to methotrexate (n = 353) were randomized to either triple therapy or methotrexate-etanercept therapy in a 48-week, double-blinded, noninferiority trial. Patients without clinical improvement at 24 weeks were switched to the alternative treatment. Of the total, 289 participated in followup. We report treatment durability, Disease Activity Score in 28 joints (DAS28), and other measures during an open-label extension for an additional period up to 72 weeks. RESULTS:Mean ± SD duration of open-label followup was 11 ± 6 months. The likelihood of continuing conventional therapy at 1 year was 78% for triple therapy versus 63% for methotrexate-etanercept, with most treatment changes occurring at the start of followup. More patients changed from methotrexate-etanercept to triple therapy than from triple therapy to methotrexate-etanercept (P = 0.005). DAS28 scores and other disease activity measures were not different for the 2 treatments and were stable during followup. CONCLUSION:In RA patients with suboptimal methotrexate response randomized to receive triple therapy or methotrexate-etanercept, the former was found to be significantly more durable. Given cost differences and similar outcomes, the variable durability demonstrated provides additional evidence supporting conventional combinations over biologic agent combinations as the first choice after methotrexate inadequate response.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Peper SM,Lew R,Mikuls T,Brophy M,Rybin D,Wu H,O'Dell Jdoi
10.1002/acr.23255subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1467-1472issue
10eissn
2151-464Xissn
2151-4658journal_volume
69pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:To examine temporal trends in mortality rates in a large nationwide cohort of patients with end-stage renal disease (ESRD) due to granulomatosis with polyangiitis (Wegener's) (GPA-ESRD). METHODS:We identified cases of GPA-ESRD reported in the US Renal Data System between 1995 and 2014, using coding by nephro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23521
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Studies have implicated foot posture and foot function as risk factors for lower extremity pain. Empirical population-based evidence for this assertion is lacking; therefore, the purpose of this study was to evaluate cross-sectional associations of foot posture and foot function to lower extremity joint pain ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22049
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The availability of reliable estimates of the burden of musculoskeletal disease is of considerable importance for policymakers. METHODS:This study uses data from the 14,507 participants of the European Health Interview Survey conducted in Austria in 2006/2007 to calculate estimates of the prevalence of osteo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20558
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine whether the effect of the Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) exercise program on hand function was mediated by changes in the proposed active ingredients: strength, dexterity, and/or range of motion. METHODS:The SARAH intervention included exercises hypothe...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23093
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To describe long-term physical functioning and its association with somatic comorbidity and comorbid depression in patients with established rheumatoid arthritis (RA). METHODS:Longitudinal data over a period of 11 years were collected from 882 patients with RA at study inclusion. Patient-reported outcomes we...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21950
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To determine if low disease activity state (LDAS)/remission predicts a better health-related quality of life (HRQoL). METHODS:Patients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQoL was measured with the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24009
更新日期:2020-08-01 00:00:00
abstract::We read with great interest the editorial on foot osteoarthritis (OA) by Golightly and Gates (1). Foot OA is prevalent but neglected compared with other commonly affected sites such as the knee and hand (2), hence such a high-profile statement of need for foot OA is long overdue. ...
journal_title:Arthritis care & research
pub_type: 信件
doi:10.1002/acr.24380
更新日期:2020-07-23 00:00:00
abstract:OBJECTIVE:To determine the risk of sick leave and work disability in relation to rheumatic diseases and cardiovascular comorbidities among working individuals. METHODS:Employees (n = 12,140) from 45 companies in The Netherlands were prospectively followed up from 1998-2008. Questionnaires were used to assess self-repo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22095
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To determine rates of cervical cancer screening and associated abnormal results in women with systemic lupus erythematosus (SLE). METHODS:We identified women with an initial diagnosis of SLE in the MarketScan Commercial Claims and Encounters Database from 2001 to 2014. Cervical cancer screening rates and ass...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24414
更新日期:2020-08-16 00:00:00
abstract:OBJECTIVE:To develop recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP). METHODS:We conducted a systematic review to synthesize the evidence for the benefits and harms of GIOP prevention and treatment options. The Grading of Recommendations Assessment, Development and Evaluation...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.23279
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The Veterans Affairs (VA) Rheumatoid Arthritis (VARA) registry and the VA Pharmacy Benefits Management database were linked to determine the association of methotrexate (MTX) adherence with rheumatoid arthritis (RA) disease activity. METHODS:For each patient, the medication possession ratio (MPR) was calcula...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20629
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. METHODS:All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox pro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22991
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To determine the occurrence of traditional cardiovascular (CV) risk factors and coronary artery calcification (CAC) in adults with polymyositis (PM) or dermatomyositis (DM) compared to healthy controls and to assess the association between CV risk factors, PM/DM, and CAC score. METHODS:Traditional CV risk fa...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22520
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To investigate the existence and distribution of 2 typologies (termed "factors") of men with rheumatoid arthritis (RA) identified through our previous Q-methodology study (n = 30) in a larger sample of men with RA, and whether differences in psychosocial impact or support preferences exist between the 2 facto...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23422
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To screen for a high risk of preeclampsia in women with systemic lupus erythematosus (SLE). METHODS:A total of 513 antenatal care records of pregnant patients with SLE were obtained, and the data were randomly assigned to either a development set (n = 342) or a validation set (n = 171). Preeclampsia predicto...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24265
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To determine time trends in the incidence and survival of polymyalgia rheumatica (PMR) over a 15-year period in Olmsted County, Minnesota, and to examine trends in incidence of PMR in the population by comparing this time period to a previous incidence cohort from the same population base. METHODS:All cases ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23132
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To assess health-related quality of life (HRQOL) in abatacept-treated children/adolescents with juvenile idiopathic arthritis (JIA). METHODS:In this phase III, double-blind, placebo-controlled trial, subjects with active polyarticular course JIA and an inadequate response/intolerance to ≥1 disease-modifying ...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/acr.20283
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To compare 3 methods for calculating the Bath Ankylosing Spondylitis Metrology Index (BASMI) score using patients who participated in the GO-RAISE study. METHODS:Patients with active ankylosing spondylitis (AS) were randomly assigned in a 1:1.8:1.8 ratio to receive subcutaneous injections of placebo, golimum...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21771
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:In early rheumatoid arthritis (RA), treating to a target is more effective than routine care (RC). Our aim was to determine if treating to a target has better outcomes than RC in established active RA. METHODS:We used a real-world, 18-month cluster-randomized trial in established active RA patients treated w...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22010
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of a 12-session walking skill training program of weight-bearing activities on physical functioning and self-efficacy initiated in patients 3 months after total hip arthroplasty (THA). METHODS:Sixty-eight patients with THA, 35 women and 33 men, with a mean age of 66 years (95% confi...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.20681
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To describe the effect of different exposure classification strategies for disease-modifying antirheumatic drugs (DMARDs) on drug-outcome associations. METHODS:We studied the association between DMARD initiation and all-cause hospitalizations in patients with rheumatoid arthritis (RA), 1995-2005. Initiators ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20087
更新日期:2010-05-01 00:00:00
abstract::Objective: To test the hypothesis that cartilage displays significant longitudinal thickening in the external subregions of the central medial (ecMF) and lateral (ecLF) femur in knees with early radiographic osteoarthritis (ROA) compared with contralateral knees without ROA, and to explore differences in change in oth...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22172
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Symptomatic knee osteoarthritis (OA) is a condition commonly associated with increased pain, disability, and functional limitations. Given the poor correspondence between radiographic evidence and clinical pain, central sensitization has been implicated as a potential mechanism underlying pain facilitation in...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22712
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Osteoarthritis (OA), a chronic degenerative joint disorder, is characterized by joint pain. Emerging research demonstrates that a significant number of patients evidence central sensitization (CS), a hyperexcitability in nociceptive pathways, which is known to amplify and maintain clinical pain. The clinical ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22609
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Fatigue is common among individuals with systemic lupus erythematosus (SLE), but the causes are not well understood. Our objective was to examine perceived stress and depressive symptoms as predictors of fatigue in SLE. METHODS:Data from 2 years of the Lupus Outcomes Study (n = 650 patients), obtained throug...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24052
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of joint-pain comorbidities in individuals with hip or knee osteoarthritis (OA) and to assess the differences in the characteristics of people with and without joint-pain comorbidities. METHODS:In this cross-sectional study, individuals referred to secondary care for treatment of ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20647
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To validate a magnetic resonance imaging (MRI) reference criterion for a positive sacroiliac (SI) joint MRI finding based on the level of confidence in the classification of spondyloarthritis (SpA) by expert MRI readers. METHODS:Four readers assessed SI joint MRIs in 2 inception cohorts (cohorts A and B) of ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21893
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Cognitive function may change over time in patients with SLE, and cognitive function trajectories have not well been studied. We aim to: 1) identify cognitive function trajectories in SLE and describe it with depressive symptoms trajectories and 2) identify baseline factors associated with class membership i...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24349
更新日期:2020-06-11 00:00:00
abstract:OBJECTIVE:To examine the association of socioeconomic status (SES) and delays in disease-modifying antirheumatic drug (DMARD) treatment with clinical measures in rheumatoid arthritis (RA) patients. METHODS:RA patients were recruited from rheumatology practices. We assessed SES based on education, occupation, and incom...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Early detection and preemptive treatment of patients at risk is of great importance in reducing the excess risk of cardiovascular (CV) disease in rheumatoid arthritis (RA). However, it is unclear how much screening is cost-effective in RA. The objective is to assess whether CV screening in RA proves to be cos...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22929
更新日期:2017-02-01 00:00:00