Abstract:
OBJECTIVE:Cachexia is a disorder characterized by involuntary weight loss in addition to loss of homeostatic control of both energy and protein balance. Despite an abundance of data from other inflammatory diseases, cachexia in SLE remains a largely undescribed syndrome. METHODS:2406 patients in a prospective SLE cohort had their weight assessed at each visit. Patients were categorized into five predetermined groups based on weight. Cachexia was defined based on modified Fearon criteria (5% stable weight loss in 6 months without starvation relative to the average weight in all prior visits AND/OR weight loss >2% without starvation relative to the average weight in all prior cohort visits and a BMI <20). Risk of cachexia within 5 years of cohort entry was based on Kaplan Meier estimates. The association of prior disease manifestations with risk of cachexia adjusted by current steroid use was determined using Cox regression. An analysis of variance test was used to determine whether SLICC/ACR Damage Index scores varied based on cachexia status. RESULTS:Within five years of cohort entry, 56% of patients developed cachexia, 18% of which never recovered their weight during follow up. The risk factors for cachexia development were BMI<20, current steroid use, vasculitis, lupus nephritis, serositis, hematologic, positive anti-dsDNA, anti-Sm, and anti-RNP. Patients with intermittent cachexia had significantly higher SLICC/ACR Damage Index compared to those with continuous cachexia or without cachexia. CONCLUSION:Cachexia is an underrecognized syndrome in patients with SLE. SLE patients with intermittent cachexia have the highest risk of future organ damage.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Stojan G,Li J,Wittmaack A,Petri Mdoi
10.1002/acr.24395subject
Has Abstractpub_date
2020-08-02 00:00:00eissn
2151-464Xissn
2151-4658pub_type
杂志文章abstract:OBJECTIVE:Joint replacement surgery is a proxy of severe joint damage in rheumatoid arthritis (RA). The aim of this study was to assess the impact of the introduction of biologic disease-modifying antirheumatic drugs (bDMARDs) on the incidence rate (IR) of upper limb joint replacements among newly diagnosed RA patients...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23835
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:To establish priority key messages for patients with osteoarthritis (OA). METHODS:A Delphi survey and priority pairwise ranking activity was conducted. Participants included 51 OA experts from 13 countries and 9 patients (consumers) living with hip and/or knee OA. During 3 Delphi rounds, the panel of experts...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22518
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:A relatively common occurrence of spontaneous subarachnoid hemorrhage (SAH) in patients with systemic lupus erythematosus (SLE) has been noted; however, the subsequent studies were conflicting. This nationwide population-based study aimed to evaluate the risk of SAH in patients with SLE. METHODS:We identifie...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21846
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Osteoarthritis (OA), a chronic degenerative joint disorder, is characterized by joint pain. Emerging research demonstrates that a significant number of patients evidence central sensitization (CS), a hyperexcitability in nociceptive pathways, which is known to amplify and maintain clinical pain. The clinical ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22609
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To assess the relative effectiveness of combining self-management and strength training for improving functional outcomes in patients with early knee osteoarthritis. METHODS:We conducted a randomized intervention trial lasting 24 months at an academic medical center. Community-dwelling middle-aged adults (n ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.20013
更新日期:2010-01-15 00:00:00
abstract:OBJECTIVE:To comprehensively evaluate the performance of the Assessment of Quality of Life (AQoL) instrument for measuring health-related quality of life (HRQOL) in people with hip and knee joint disease (arthritis or osteoarthritis). METHODS:Data from 237 individuals were available for analysis from a national cross-...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.22129
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Low-dose aspirin may reduce the risk of developing rheumatoid arthritis (RA) through its effect on cyclooxygenase activity and its antioxidant pathways. Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorect...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20042
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Total knee replacement (TKR) is an effective treatment for end-stage knee osteoarthritis (OA). American racial minorities undergo fewer TKRs than whites. We estimated quality-adjusted life-years (QALYs) lost for African American knee OA patients due to differences in TKR offer, acceptance, and complication ra...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23484
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To identify and describe back pain trajectory groups and to compare indicators of health status, medication, and health care use in these groups. METHODS:A representative sample (n = 12,782) of the Canadian population was followed-up from 1994/1995 to 2010/2011. Participants were interviewed biannually and p...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23811
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To describe long-term physical functioning and its association with somatic comorbidity and comorbid depression in patients with established rheumatoid arthritis (RA). METHODS:Longitudinal data over a period of 11 years were collected from 882 patients with RA at study inclusion. Patient-reported outcomes we...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21950
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23285
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We compared patient-reported outcomes (PROs) in patients with RA treated with tofacitinib or placebo in combination with conventional disease-modifying antirheumatic drugs (DMARDs). METHODS:In a 12-month, phase III ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23004
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To examine the association between socioeconomic status (SES) and delay to a pediatric rheumatology clinic, disease severity, and illness perception in patients with juvenile idiopathic arthritis in England. METHODS:Using the Index of Multiple Deprivation, 923 consecutive children from the Childhood Arthriti...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22466
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To assess the extent and determinants of discordance in scoring between patient global assessment (PtGA) and physician global assessment (PhGA) in patients with psoriatic arthritis (PsA). METHODS:A cross-sectional and longitudinal analysis of data was conducted in patients attending a large PsA clinic. The d...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22401
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To establish the impact of uveitis on the quality of life (QoL) in adult patients with juvenile idiopathic arthritis (JIA). METHODS:Adult patients with a history of JIA, both with (n = 31) or without (n = 51) chronic anterior uveitis, were included. Their scores on 3 validated QoL questionnaires (National Ey...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23224
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of a 12-session walking skill training program of weight-bearing activities on physical functioning and self-efficacy initiated in patients 3 months after total hip arthroplasty (THA). METHODS:Sixty-eight patients with THA, 35 women and 33 men, with a mean age of 66 years (95% confi...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.20681
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. METHODS:Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20571
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine factors that are predictive of incident, recurrent, or resolved shoulder pain in a community-based sample from the general population. METHODS:This study used data from the North West Adelaide Health Study, a cohort study located in the northwestern suburbs of Adelaide, South Australia. Data wer...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22082
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Telemedicine is increasingly being offered to patients for rheumatology care, but few studies have examined factors associated with telemedicine use or outcomes of telemedicine in rheumatology. The objective of this analysis was to determine factors associated with the use of video telemedicine when offered a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24049
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To describe the experiences and strategies of employees with arthritis to maintain employment, and to use this information to build a conceptual model. METHODS:We conducted a systematic review of qualitative studies that examined the work experiences of employees with arthritis. Published studies on arthriti...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23528
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the validity of different spondyloarthritis (SpA) features included in the Berlin diagnostic algorithm and the Assessment of SpondyloArthritis international Society (ASAS) classification criteria in an early SpA cohort. METHODS:This was a longitudinal multicenter study including patients from the...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23017
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Knowledge about systemic lupus erythematosus (SLE) outcomes among US Asians is lacking. We examined SLE disease activity, severity, and damage among Asians of primarily Chinese and Filipino descent in a multiethnic cohort. METHODS:California Lupus Epidemiology Study (CLUES, n=328) data were analyzed. Data we...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24544
更新日期:2020-12-18 00:00:00
abstract:OBJECTIVE:To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA). METHODS:The Cohort Hip & Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n = 1,002) with early OA-related knee and/or hip symptoms, was follow...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20263
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To validate a magnetic resonance imaging (MRI) reference criterion for a positive sacroiliac (SI) joint MRI finding based on the level of confidence in the classification of spondyloarthritis (SpA) by expert MRI readers. METHODS:Four readers assessed SI joint MRIs in 2 inception cohorts (cohorts A and B) of ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21893
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to evaluate changes in knee magnetic resonance imaging (MRI) findings over the course of 18 months in subjects with osteoarthritic change and meniscal tear treated with arthroscopic partial meniscectomy (APM) or nonoperatively with physical therapy (PT). METHODS:We used 18-mo...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23891
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Localized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients. METHODS:We analyzed longitudinal data from a single-center cohort of juvenile localiz...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23101
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To systematically review evidence of the impact of inflammatory arthritis on, or association of inflammatory arthritis with, intimate relationships and sexual function. METHODS:Ovid Medline, Ovid PsycINFO, Ovid Embase, and EBSCO CINAHL databases were searched. Two independent reviewers selected articles, ext...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23857
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations of diffuse idiopathic skeletal hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS:DISH and kyphosis were assessed in 1,500 men from the Osteoporotic Fractures in Men (MrOS) study and in 1,267 women from the Study of Osteoporotic Fr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23115
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Prior investigations demonstrated that autoantibodies recognizing cytosolic 5'-nucleotidase 1A (NT5C1A) are found in 33-76% of patients with inclusion body myositis (IBM) but are observed only rarely in patients with polymyositis (PM). Thus, anti-NT5C1A may help distinguish IBM from PM. Although 4-21% of pati...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22600
更新日期:2016-01-01 00:00:00