当前位置： SCI文献检索 > ARTHRITIS CARE & RESEARCH期刊下所有文献 > Effects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adult population.

Effects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adult population.

Abstract：

OBJECTIVE:Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) are markers to rheumatoid arthritis (RA). Smoking and shared epitope (SE) in HLA-DRB1 are associated with the production of these autoantibodies in RA. Detailed distribution and characterization of ACPA and RF in the general population have remained unclear. We aimed to evaluate positivity of ACPA and RF in a general Japanese population and to detect correlates, including genetic components. METHODS:ACPA and RF were quantified in 9,804 Japanese volunteers ages 30-75 years. Logistic regression analyses were performed to evaluate the effects of candidates of correlates on the autoantibody positivity. A genome-wide association study (GWAS) was performed using 394,239 single nucleotide polymorphisms for 3,170 participants, and HLA-DRB1 alleles were imputed based on the GWAS data. RESULTS:A total of 1.7% and 6.4% of subjects were positive for ACPA and RF, respectively, and the 2 markers showed a significant correlation (P = 2.0 × 10(-23) ). Old age was associated with ACPA positivity (P = 0.00062). Sex, smoking, SE, and other candidates of correlates did not have significant effects. Interaction between smoking and SE positivity was not apparent, but smoking showed a significant association with high levels of ACPA (P = 0.0019). CONCLUSION:ACPA and RF could be detected in 1.7% and 6.4% of the Japanese adult population without RA, respectively. ACPA and RF were suggested to share mechanisms even in healthy populations. Old age was associated with increasing ACPA positivity. While positivity of ACPA and RF was not associated with SE and smoking, an association between high ACPA and smoking was observed.

journal_name

Arthritis Care Res (Hoboken)

journal_title

Arthritis care & research

authors

Terao C,Ohmura K,Ikari K,Kawaguchi T,Takahashi M,Setoh K,Nakayama T,Kosugi S,Sekine A,Tabara Y,Taniguchi A,Momohara S,Yamanaka H,Yamada R,Matsuda F,Mimori T,Nagahama Study Group.

doi

10.1002/acr.22385

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1818-27

issue

eissn

2151-464X

issn

2151-4658

journal_volume

pub_type

杂志文章

在线工具

Effects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adult population.