Abstract:
OBJECTIVE:This prospective study aimed to determine whether the comprehensive ultrasonographic assessment of synovial inflammation predicts relapse after discontinuation of treatment with a biologic agent in patients with rheumatoid arthritis (RA) in clinical remission. METHODS:RA patients in clinical remission (Disease Activity Score in 28 joints [DAS28] <2.6) receiving treatment with a biologic agent who agreed to discontinue the treatment were recruited. Patients underwent a comprehensive ultrasound scan on 134 synovial sites in 40 joints and were prospectively followed up for 6 months. Physicians who evaluated the patients during the study period were blinded to the baseline ultrasound findings. RESULTS:Forty-two patients receiving either a tumor necrosis factor antagonist or tocilizumab were enrolled. Using the optimal cutoff values determined by receiver operating characteristic curve analysis, relapse rates were significantly higher in patients whose total ultrasound scores at discontinuation were high than in those whose total ultrasound scores were low (P < 0.001 for both total gray-scale and power Doppler scores), whereas the difference between high and low DAS28 was not statistically significant (P = 0.158 by log rank test). Positive and negative predictive values were 80.0% and 73.3% for the total gray-scale score and 88.9% and 74.2% for the total power Doppler score, respectively. CONCLUSION:In RA patients in clinical remission receiving treatment with a biologic agent, residual synovial inflammation determined by comprehensive ultrasound assessment predicted relapse within a short term after discontinuation of the treatment. Our data provide a rationale and groundwork to conduct a large-scale study for establishment of ultrasound-based strategies to optimize the period of treatment with a biologic agent.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Iwamoto T,Ikeda K,Hosokawa J,Yamagata M,Tanaka S,Norimoto A,Sanayama Y,Nakagomi D,Takahashi K,Hirose K,Sugiyama T,Sueishi M,Nakajima Hdoi
10.1002/acr.22303subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1576-81issue
10eissn
2151-464Xissn
2151-4658journal_volume
66pub_type
杂志文章abstract:OBJECTIVE:To examine the association between weight change from young adulthood to midlife and risk of incident arthritis. METHODS:Using data from the National Health and Nutrition Examination Survey (NHANES), we categorized participants into weight change categories based on their recalled weight during young adultho...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24252
更新日期:2020-05-06 00:00:00
abstract:OBJECTIVE:To describe the experiences and strategies of employees with arthritis to maintain employment, and to use this information to build a conceptual model. METHODS:We conducted a systematic review of qualitative studies that examined the work experiences of employees with arthritis. Published studies on arthriti...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23528
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Interrater variability limits rheumatologic opinion as a reference standard for early inflammatory arthritis (IA) classification. The study objectives were to determine whether rheumatologic opinion is associated with potential early IA classification methods despite high interrater variability, and to compar...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1002/acr.20250
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To examine work absenteeism, job disruptions, and perceived productivity loss and factors associated with each outcome in young adults living with systemic lupus erythematosus (SLE) and juvenile arthritis (JA). METHODS:One hundred forty-three young adults, ages 18-30 years with SLE (54.5%) and JA (45.5%), co...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22601
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:This double-blind randomized controlled trial aimed to test the efficacy of self-administered acupressure for pain and physical function improvement for older adults with knee osteoarthritis (OA). METHODS:Participants were community-dwelling adults with symptomatic knee OA (n = 150, mean age 73 years), rando...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23262
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To determine if baseline 3-dimensional (3-D) biomechanical gait patterns differed between those patients with moderate knee osteoarthritis (OA) who progressed to total knee arthroplasty (TKA) and those that did not, and whether these differences had predictive value. METHODS:Fifty-four patients with knee OA ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22564
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To examine the association between leisure time physical exercise, body mass index (BMI), and risk of fibromyalgia (FM). METHODS:A longitudinal study with baseline assessment of physical exercise (frequency, duration, and intensity) and BMI was used to explore the risk of having FM at 11-year followup in a l...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20118
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To determine if mortality is increased among patients diagnosed as having fibromyalgia. METHODS:We studied 8,186 fibromyalgia patients seen between 1974 and 2009 in 3 settings: all fibromyalgia patients in a clinical practice, patients participating in the US National Data Bank for Rheumatic Diseases (NDB), ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20301
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To determine the clinical manifestations and disease damage associated with discoid rash in a large multiethnic systemic lupus erythematosus (SLE) cohort. METHODS:SLE patients (per American College of Rheumatology [ACR] criteria) ages ≥16 years with a disease duration of ≤10 years at enrollment and defined e...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21581
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:The RhoA/Rho kinase pathway plays a pivotal role in cold-induced vasoconstriction, vascular smooth muscle cells function, and vascular homeostasis. This study evaluates the efficacy of fasudil, a RhoA/Rho kinase inhibitor, to reverse cold-induced vasospasm in patients with Raynaud's phenomenon (RP) secondary ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21622
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:This study was performed to determine the prevalence of elevated C-reactive protein (CRP) levels and the significance of CRP in clinical parameters in systemic sclerosis (SSc; scleroderma) patients. METHODS:Canadian Scleroderma Research Group data were used. Statistical comparisons were made for CRP levels ≤...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21716
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To study the epidemiology of hospitalized serious infections in people with gout. METHODS:We identified people with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract infection (UTI), skin and soft tissue infections (SSTI), or opportunistic infections (OI) in 1998-2016 ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24201
更新日期:2020-04-05 00:00:00
abstract:OBJECTIVE:There are few reports on the treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) in children. This study characterizes the use of cyclophosphamide, rituximab, and plasma exchange in children hospitalized with AAV in the US. METHODS:We conducted a retrospective cohort study of childre...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23142
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To investigate the use of glucocorticoids (GCs) and related adverse events (AEs) in a long-term, geographically defined cohort of patients with polymyalgia rheumatica (PMR). METHODS:Using a population-based inception cohort, details of GC therapy were abstracted from medical records of all patients diagnosed...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23320
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To validate the pediatric Patient-Reported Outcomes Measurement Information System short forms (PROMIS-SFs) in childhood-onset systemic lupus erythematosus (SLE) in a clinical setting. METHODS:At 3 study visits, childhood-onset SLE patients completed the PROMIS-SFs (anger, anxiety, depressive symptoms, fatig...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22927
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To examine clinical characteristics as possible predictors of long-term treatment continuation with adalimumab, etanercept, and infliximab in ankylosing spondylitis (AS) patients who had never taken biologics treated in clinical practice. METHODS:Patients in southern Sweden with active AS starting biologic t...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20258
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:In a pilot study, our group showed that an internet-based self-management program improves self-efficacy in systemic sclerosis (SSc). The objective of the current study was to compare an internet-based self-management program to a patient-focused educational book developed to assess measures of self-efficacy ...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23595
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To explore the link between a patient acceptable symptom state (PASS) and patient-perceived impact in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS:This was a cross-sectional study of unselected patients with definite RA or PsA. Pain, functional capacity, fatigue, coping, and sleep disturb...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23176
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:In early rheumatoid arthritis (RA), treating to a target is more effective than routine care (RC). Our aim was to determine if treating to a target has better outcomes than RC in established active RA. METHODS:We used a real-world, 18-month cluster-randomized trial in established active RA patients treated w...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22010
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) are markers to rheumatoid arthritis (RA). Smoking and shared epitope (SE) in HLA-DRB1 are associated with the production of these autoantibodies in RA. Detailed distribution and characterization of ACPA and RF in the general population have...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22385
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To evaluate if exercise programs in trials for patients with ankylosing spondylitis (AS) have the potential for effectiveness. METHODS:A systematic literature search was performed and randomized trials examining the effectiveness of exercise programs for AS patients were analyzed according to 3 elements: whe...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20415
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. METHODS:All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox pro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22991
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus patients are frequently evaluated for chest pain and may have multiple pulmonary embolism (PE) computed tomography (CT) scans. This study was undertaken to determine the incidence of pulmonary embolism in the University of Michigan Lupus Cohort patients who have undergone PE CT sc...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22684
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To explore patients' knowledge and beliefs about osteoarthritis (OA) and OA risk following anterior cruciate ligament (ACL) injury, to explore the extent to which information about these risks is provided by health professionals, and to examine associations among participant characteristics, knowledge, and ri...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22794
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate the response of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) by ultrasonographic evaluation of changes in the wrist and hand, and to determine whether such assessments during early TCZ treatment predict later clinical outcome. METHODS:Thirty-two RA patients about to receive TCZ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20537
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The role of cardiovascular disease (CVD) risk factors in psoriatic arthritis (PsA) is poorly understood. We examined the prevalence of CVD risk factors at initial onset of PsA and compared the observed incidence of CVD events with that predicted by the Framingham Risk Score (FRS) to determine its applicabilit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22536
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of overweight and obese Canadians with arthritis and to describe their use of arthritis self-management strategies, as well as explore the factors associated with not engaging in any self-management strategies. METHODS:Respondents to the 2009 Survey on Living with Chronic Diseases ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20654
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To examine temporal trends in mortality rates in a large nationwide cohort of patients with end-stage renal disease (ESRD) due to granulomatosis with polyangiitis (Wegener's) (GPA-ESRD). METHODS:We identified cases of GPA-ESRD reported in the US Renal Data System between 1995 and 2014, using coding by nephro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23521
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To examine the association of socioeconomic status (SES) and delays in disease-modifying antirheumatic drug (DMARD) treatment with clinical measures in rheumatoid arthritis (RA) patients. METHODS:RA patients were recruited from rheumatology practices. We assessed SES based on education, occupation, and incom...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00