Abstract:
OBJECTIVE:To investigate the use of glucocorticoids (GCs) and related adverse events (AEs) in a long-term, geographically defined cohort of patients with polymyalgia rheumatica (PMR). METHODS:Using a population-based inception cohort, details of GC therapy were abstracted from medical records of all patients diagnosed with PMR in 2000-2014. Age- and sex-matched comparators without PMR were identified from the same underlying population. Cumulative and daily dosage of GC, rate of disease relapse, occurrence of GC-related AEs, and rate of GC discontinuation were analyzed. RESULTS:The study included 359 patients with PMR and 359 comparators. The median time to taper below 5 mg/day for 6 months was 1.44 years (95% confidence interval [95% CI] 1.36-1.62), while the median time to permanent discontinuation was 5.95 years (95% CI 3.37-8.88). The mean ± SD cumulative dose of GC at 2 and 5 years was 4.0 ± 3.5 grams and 6.3 ± 9.8 grams, respectively. The mean ± SD daily dose of GC at 2 and 5 years was 6.1 ± 7.6 mg/day and 7.2 ± 9.5 mg/day, respectively. There were no differences in rates of AEs between patients with PMR and comparators for diabetes mellitus, hypertension, hyperlipidemia, or hip, vertebral, or Colles fractures (P > 0.2 for all). Cataracts were more common in patients with PMR than comparators (hazard ratio 1.72 [95% CI 1.23-2.41]). CONCLUSION:Relapse rates in PMR are highest in the early stages of therapy. Despite often protracted therapy, with the exception of cataracts, the rates of studied morbidities linked to GC are not more common in PMR than comparators.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Shbeeb I,Challah D,Raheel S,Crowson CS,Matteson ELdoi
10.1002/acr.23320subject
Has Abstractpub_date
2018-04-01 00:00:00pages
643-647issue
4eissn
2151-464Xissn
2151-4658journal_volume
70pub_type
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journal_title:Arthritis care & research
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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