Abstract:
OBJECTIVE:To determine if baseline 3-dimensional (3-D) biomechanical gait patterns differed between those patients with moderate knee osteoarthritis (OA) who progressed to total knee arthroplasty (TKA) and those that did not, and whether these differences had predictive value. METHODS:Fifty-four patients with knee OA had ground reaction forces and segment motions collected during gait. 3-D hip, knee, and ankle angles and moments were calculated over the gait cycle. Amplitude and temporal waveform characteristics were determined using principal component analysis. At followup 5-8 years later, 26 patients reported undergoing TKA. Unpaired t-tests were performed on baseline demographic and waveform characteristics between TKA and no-TKA groups. Receiver operating curve analysis, stepwise discriminate analysis, and logistic regression analysis determined the combination of features that best classified TKA and no-TKA groups and their predictive ability. RESULTS:Baseline demographic, symptomatic, and radiographic variables were similar, but 7 gait variables differed (P < 0.05) between groups. A multivariate model including overall knee adduction moment magnitude, knee flexion/extension moment difference, and stance-dorsiflexion moment had a 74% correct classification rate, with no overtraining based on cross-validation. A 1-unit increase in model score increased by 6-fold the odds of progression to TKA. CONCLUSION:In addition to the link between higher overall knee adduction magnitude and future TKA, an outcome of clear clinical importance, novel findings include altered sagittal plane moment patterns indicative of reduced ability to unload the joint during midstance. This combination of dynamic biomechanical factors had a 6-fold increased odds of future TKA; adding baseline demographic and clinical factors did not improve the model.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Hatfield GL,Stanish WD,Hubley-Kozey CLdoi
10.1002/acr.22564subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1004-14issue
7eissn
2151-464Xissn
2151-4658journal_volume
67pub_type
杂志文章abstract:OBJECTIVE:To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM). METHODS:We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi-square or Fisher's exact tests and used univariate and multivariate lo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22498
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of severe fatigue and fatigue-related limitations among adolescents with juvenile idiopathic arthritis (JIA) and other pediatric rheumatic diseases (PRDs). In addition, we assessed the effect of disease activity and pain on the severity of fatigue. METHODS:This cross-sectional stu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22710
更新日期:2016-01-01 00:00:00
abstract::History of the present illness: A four-year-old female presented to our pediatric rheumatology clinic with chief complaint of periodic fevers and abdominal pain. Fevers began 4 months prior to presentation following a documented streptococcal pharyngeal infection, with a maximum temperature of 104F. They occurred ever...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24428
更新日期:2020-08-19 00:00:00
abstract:OBJECTIVE:Disease activity, organ damage, and treatment burden are often substantial in children and adolescents with systemic lupus erythematous (SLE), and the complex interplay among the developing child, parents, and peers makes effective management difficult. We aimed to describe the experiences and perspectives of...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22749
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To validate the pediatric Patient-Reported Outcomes Measurement Information System short forms (PROMIS-SFs) in childhood-onset systemic lupus erythematosus (SLE) in a clinical setting. METHODS:At 3 study visits, childhood-onset SLE patients completed the PROMIS-SFs (anger, anxiety, depressive symptoms, fatig...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22927
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Despite the high prevalence of depression among vulnerable Hispanics with rheumatoid arthritis (RA), many do not disclose it or seek treatment. This study explored patient perceptions of depression, its association with their primary disease, barriers to disclosure, reasons for low utilization of mental healt...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22462
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Concerns about SARS-CoV-2 infection may have led to changes or discontinuation of immunosuppressive medications among patients with systemic rheumatic disease. Our goal was to assess patients' perspectives regarding medication modifications and deviations from planned uses during the height of the pandemic. ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24489
更新日期:2020-10-21 00:00:00
abstract:OBJECTIVE:To investigate demographic, symptom-related, and cognitive determinants of cane use for knee osteoarthritis (OA) and prioritize the factors that could facilitate cane use in people with no previous cane use. METHODS:A survey of people ages ≥45 years with a clinical diagnosis of knee OA was conducted. The sur...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23494
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The Psoriatic Arthritis Disease Activity Score (PASDAS) is a composite measure of psoriatic arthritis (PsA) disease activity. The length of its patient-reported components raises concern about questionnaire burden. The PASDAS includes the Medical Outcomes Study Short Form 36 (SF-36) health survey. We undertoo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23876
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To determine whether a decline in walking speed during the year prior to disease onset is associated with concurrent changes in cartilage, bone marrow lesions (BMLs), or effusion in adults who develop common knee osteoarthritis (OA), accelerated knee OA, or no knee OA. METHODS:We identified 3 groups from the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23613
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To validate manual muscle testing (MMT) for strength assessment in juvenile and adult dermatomyositis (DM) and polymyositis (PM). METHODS:Patients with PM/DM (73 children and 45 adults) were assessed at baseline and reevaluated 6-9 months later. We compared Total MMT (a group of 24 proximal, distal, and axia...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/acr.20035
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23102
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between exposure to oral contraceptives (OCs) and clinical outcomes in an early arthritis cohort. METHODS:Female patients with early inflammatory arthritis, ages 18-60 years, who were enrolled in an early arthritis cohort and had no exposure to hormone replacement were studied (n ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22667
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To identify and describe back pain trajectory groups and to compare indicators of health status, medication, and health care use in these groups. METHODS:A representative sample (n = 12,782) of the Canadian population was followed-up from 1994/1995 to 2010/2011. Participants were interviewed biannually and p...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23811
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA). METHODS:This was an assessor-blinded, 3-arm randomized controlled trial in 22...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22744
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To establish the impact of uveitis on the quality of life (QoL) in adult patients with juvenile idiopathic arthritis (JIA). METHODS:Adult patients with a history of JIA, both with (n = 31) or without (n = 51) chronic anterior uveitis, were included. Their scores on 3 validated QoL questionnaires (National Ey...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23224
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:Hydroxychloroquine (HCQ) has been associated with improved survival among SLE patients from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. METHODS:We conducted a nested case-control study within an incide...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24255
更新日期:2020-05-14 00:00:00
abstract:OBJECTIVE:To screen for a high risk of preeclampsia in women with systemic lupus erythematosus (SLE). METHODS:A total of 513 antenatal care records of pregnant patients with SLE were obtained, and the data were randomly assigned to either a development set (n = 342) or a validation set (n = 171). Preeclampsia predicto...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24265
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. METHODS:All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox pro...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22991
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Localized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients. METHODS:We analyzed longitudinal data from a single-center cohort of juvenile localiz...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23101
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:The hepatitis B virus (HBV) testing rates and patterns in rheumatoid arthritis (RA) patients starting disease-modifying antirheumatic drugs (DMARDs) have not been well studied. We describe and compare the practice patterns of HBV testing among RA patients in the US and Taiwan. METHODS:We conducted a retrospe...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23241
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To determine if low disease activity state (LDAS)/remission predicts a better health-related quality of life (HRQoL). METHODS:Patients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQoL was measured with the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24009
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To compare the relative effectiveness of anti-tumor necrosis factor (anti-TNF) therapies on health-related quality of life (HRQOL) by inflammatory arthritis types. METHODS:Patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) who had anti-TNF therapy (etanercept,...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22151
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) predominantly affects women. Clinical phenotype and outcomes in SLE may vary by sex and are further complicated by unique concerns that are dependent upon sex-defined roles. We aimed to describe sex differences in disease-specific quality of life (QoL) assessment scores usin...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23588
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:The Veterans Affairs (VA) Rheumatoid Arthritis (VARA) registry and the VA Pharmacy Benefits Management database were linked to determine the association of methotrexate (MTX) adherence with rheumatoid arthritis (RA) disease activity. METHODS:For each patient, the medication possession ratio (MPR) was calcula...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20629
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Immunosuppressive therapy may trigger hepatitis B virus (HBV) reactivation for increased morbidity and mortality. We aimed to describe HBV reactivation in patients receiving treatment for immune-mediated inflammatory diseases (IMIDs) and to evaluate a predefined algorithm for its prevention. METHODS:Physicia...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.21990
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To determine if a pharmacist-initiated multidisciplinary strategy provides value for money compared to usual care in participants with previously undiagnosed knee osteoarthritis. METHODS:Pharmacies were randomly allocated to provide either 1) usual care and a pamphlet or 2) intervention care, which consisted...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22232
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of magnetic resonance imaging (MRI) osteoarthritis (OA) features in the patellofemoral or tibiofemoral joint (i.e., bone marrow lesions, cartilage lesions, and osteophytes) and/or functional impairments, 1 year following anterior cruciate ligament reconstruction (ACLR), can p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22761
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To systematically review evidence of the impact of inflammatory arthritis on, or association of inflammatory arthritis with, intimate relationships and sexual function. METHODS:Ovid Medline, Ovid PsycINFO, Ovid Embase, and EBSCO CINAHL databases were searched. Two independent reviewers selected articles, ext...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23857
更新日期:2020-01-01 00:00:00