Abstract:
OBJECTIVE:The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle-aged individuals with hip or knee pain. Radiographs were assigned Kellgren & Lawrence (KL) scores under different conditions at each follow-up visit for 10 years. We aimed to describe and consolidate each scoring approach, then illustrate implications of their use by comparing baseline KL scores assigned using two of these approaches, and evaluating their respective associations with joint replacement and incident radiographic osteoarthritis (ROA). METHODS:We compared baseline KL scores assigned to hips and knees using two scoring approaches: (i) assigned by senior researchers to baseline images alone, and (ii) assigned by trained readers, read paired and in known sequence with up to 10 years of follow-up radiographs (Poisson regression). We evaluated the associations of baseline ROA (any ≥ KL1, established ≥ KL2) with joint replacement, and of KL1 joints with incident established ROA (survival analysis). RESULTS:Of 1002 participants (79% women, mean (SD) age 55.9 (5.2) years, BMI 26.2 (4.0) kg/m2 ), the second scoring approach had 2.4 (95% CI 1.8-3.1, knees) and 2.9 (2.3-3.7, hips) times higher prevalence of established ROA than the first approach. Established hip ROA had higher risk of joint replacement using the first approach (Hazard Ratio, HR 24.2 (95%CI 15.0-39.8) vs. 7.7 (4.9-12.1), second approach), as did knees (19.3 (10.3-36.1) vs. 4.8 (2.4-9.6)). Risk of incident ROA did not differ by approach. CONCLUSIONS:This study demonstrates that evaluating ROA prevalence and predicting outcomes depends on scoring approach.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Macri EM,Runhaar J,Damen J,Oei EH,Bierma-Zeinstra SMdoi
10.1002/acr.24563subject
Has Abstractpub_date
2021-01-15 00:00:00eissn
2151-464Xissn
2151-4658pub_type
杂志文章abstract:OBJECTIVE:To determine the relationship between biochemical markers involved in bone turnover and bone features on imaging in knees with osteoarthritis (OA). METHODS:We analyzed data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600). Bone ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23121
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To determine the impact of stopping tumor necrosis factor inhibitor (TNFi) treatment on patient-reported outcomes (PROs) of physical and mental health status, health utility, pain, disability, and fatigue in patients with established rheumatoid arthritis (RA). METHODS:In the pragmatic, 12-month POET trial, 8...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23315
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. METHODS:Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20571
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The efficacy and safety of subcutaneous tocilizumab (TCZ-SC) versus subcutaneous placebo (PBO-SC) was evaluated in patients with rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs in the BREVACTA study. METHODS:Patients (n = 656) were randomized 2:1 to receive TCZ-SC...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.22384
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. METHODS:The population-based Framingham Foot Study assessed HV, foot pain...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22391
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23285
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To describe and compare triennial rates of physicians' recommendations for physical therapy (PT), lifestyle counseling, and pain medication for knee osteoarthritis (OA) and to identify patient, physician, and practice factors associated with each treatment recommendation. METHODS:We conducted a cross-section...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24064
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:To investigate whether patients affected by 1 of the 3 subsets of early systemic sclerosis (SSc; scleroderma), i.e., subset I, Raynaud's phenomenon with SSc marker autoantibodies and typical capillaroscopic findings; subset II, autoantibody positive only; and subset III, capillaroscopy positive only and not s...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22304
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the feasibility and effectiveness of neuromuscular electrical stimulation (NMES) with that of high-intensity volitional resistance training for improving muscle structure and function and physical function in patients with rheumatoid arthritis (RA). We also compared pre-in...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.23602
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Competent examination of the pediatric musculoskeletal (MSK) system is a vital component of clinical assessment of children with MSK presentations. The aim was to develop a regional MSK examination for school-age children that is age appropriate and reflects clinical practice. METHODS:Qualitative and quantit...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20569
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To summarize the state of knowledge regarding the economic burden of systemic lupus erythematosus (SLE) and to evaluate the quality of cost-of-illness (COI) studies conducted to date. METHODS:Relevant literature was retrieved from the PubMed database in April 2010. The evaluation of identified articles was b...
journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.20410
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:We assessed implementation of the 10-item Patient-Reported Outcomes Measurement Information System (PROMIS) physical function form (PF-10a) in routine practice in a racially and ethnically diverse population with rheumatoid arthritis (RA). Objectives were to determine feasibility of implementing PF-10a in the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22956
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To examine the effects of individual and local level socioeconomic status (SES) and health care access characteristics on the number of self-report physician visits for systemic lupus erythematosus (SLE). METHODS:Data derived from 755 adult participants from the 2004 to 2007 Lupus Outcomes Study (LOS) result...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20125
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:This prospective study aimed to determine whether the comprehensive ultrasonographic assessment of synovial inflammation predicts relapse after discontinuation of treatment with a biologic agent in patients with rheumatoid arthritis (RA) in clinical remission. METHODS:RA patients in clinical remission (Disea...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22303
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To assess experimental pain sensitivity and compare the inflammatory response to pain in 26 osteoarthritis (OA) patients and 33 age- and sex-matched controls from the general population in order to examine the nature of the association between pain and inflammation in OA. METHODS:The participants underwent p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20373
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To determine the risk of sick leave and work disability in relation to rheumatic diseases and cardiovascular comorbidities among working individuals. METHODS:Employees (n = 12,140) from 45 companies in The Netherlands were prospectively followed up from 1998-2008. Questionnaires were used to assess self-repo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22095
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Although it is common for rheumatologists to initiate biologic agents after failure of methotrexate monotherapy in rheumatoid arthritis (RA), ample data support the initial use of combinations of conventional therapies in this clinical scenario. Our study explores the durability of triple therapy (methotrexat...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23255
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To investigate demographic, symptom-related, and cognitive determinants of cane use for knee osteoarthritis (OA) and prioritize the factors that could facilitate cane use in people with no previous cane use. METHODS:A survey of people ages ≥45 years with a clinical diagnosis of knee OA was conducted. The sur...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23494
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE a...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23009
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA). METHODS:This was an assessor-blinded, 3-arm randomized controlled trial in 22...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.22744
更新日期:2016-05-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,评审
doi:10.1002/acr.22050
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To determine the influence of socioeconomic factors on disease activity in a Latin American (LA) early rheumatoid arthritis (RA) multinational inception cohort at baseline. METHODS:Clinical evaluation, ethnicity, socioeconomic status (SES), 4-variable Disease Activity Score in 28 joints using the erythrocyte...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21680
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Early detection and preemptive treatment of patients at risk is of great importance in reducing the excess risk of cardiovascular (CV) disease in rheumatoid arthritis (RA). However, it is unclear how much screening is cost-effective in RA. The objective is to assess whether CV screening in RA proves to be cos...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22929
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To identify a combination of clinical factors associated with low disease activity and remission in the third trimester during pregnancy in women with rheumatoid arthritis (RA). METHODS:This study is embedded in the Pregnancy-Induced Amelioration of Rheumatoid Arthritis study, a prospective cohort study. The...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23143
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To examine trends in glucocorticoid (GC) use and dosing among patients diagnosed with rheumatoid arthritis (RA) over time. METHODS:A population-based inception cohort of RA patients diagnosed during 1980-2007 was followed longitudinally through their medical records until death, migration, or December 31, 20...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22365
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:A relatively common occurrence of spontaneous subarachnoid hemorrhage (SAH) in patients with systemic lupus erythematosus (SLE) has been noted; however, the subsequent studies were conflicting. This nationwide population-based study aimed to evaluate the risk of SAH in patients with SLE. METHODS:We identifie...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21846
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Digital ulcers represent one of the most frequent complications of systemic sclerosis (SSc; scleroderma); they are very painful, scarcely responsive to treatment, and often responsible for marked limitations on daily activities, including patient self-care. Infectious complications may severely compromise the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20673
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To understand the impact of ankylosing spondylitis (AS) on work disability (WD) over 12 years compared with the general population, and explore factors predicting adverse work outcome, defined as new partial WD or reduction in working hours. METHODS:Source of data was the Outcome Assessments in Ankylosing Sp...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22730
更新日期:2016-04-01 00:00:00
abstract::In this issue of AC&R, Hauser et. al. compare the prevalence of fibromyalgia (FM) in a German population using the 2016 Modified ACR criteria to the prevalence using the new ACTTION-APS Pain Taxonomy (AAPT) criteria. ...
journal_title:Arthritis care & research
pub_type: 社论
doi:10.1002/acr.24198
更新日期:2020-04-05 00:00:00
abstract:OBJECTIVE:To describe 1) a technique that can detect synovial effusions not seen on static ultrasound (US) examination and 2) the characteristics of patients with knee osteoarthritis (OA) for whom this technique proved useful. METHODS:From reviewed records of 76 patients with knee OA (112 knees) that we had seen for U...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.20047
更新日期:2010-05-01 00:00:00