Abstract:
OBJECTIVE:Pulmonary arterial hypertension (PAH) is a rare but serious complication of systemic lupus erythematosus (SLE). Chronic hypoxia is known to cause PAH resulting from pulmonary vascular remodeling. We investigated the association between anemic hypoxia and PAH in SLE patients. METHODS:Systolic pulmonary artery pressure (PAP) was measured in 132 SLE patients by echocardiography. Increased PAP was defined as resting PAP > 40 mm Hg. Oxygen delivery (DO2) was estimated as the product of cardiac output and arterial oxygen content. RESULTS:Of 132 patients, 17 (12.9%) had increased PAP, and these patients had significantly lower DO2 values than patients with normal PAP (P = 0.002). The DO2 values inversely correlated with PAP values (γ = -0.308, P < 0.001) and plasma N-terminal pro-brain natriuretic peptide levels (γ = -0.323, P = 0.001), but positively correlated with hemoglobin levels (γ = 0.402, P < 0.001). Compared to those with normal PAP, patients with increased PAP had significantly longer durations of anemia over the preceding 6-24 months. Patients with anemia of longer durations (≥3 months) in the preceding 6 months had a higher risk of increased PAP compared to those with shorter durations (P < 0.001). When SLE patients were divided into 3 groups according to hemoglobin and PAP, serum interleukin-6 (IL-6) levels increased across groups with higher PAP (P = 0.001 for trend), but decreased across tertiles of hemoglobin levels (P = 0.008 for trend). CONCLUSION:Our data indicate an association between chronic anemic hypoxia and increased PAP in SLE patients and suggest that increased IL-6 might participate in this process.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Kim KJ,Baek IW,Yoon CH,Kim WU,Cho CSdoi
10.1002/acr.22630subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1702-11issue
12eissn
2151-464Xissn
2151-4658journal_volume
67pub_type
杂志文章,多中心研究abstract:OBJECTIVE:We assessed implementation of the 10-item Patient-Reported Outcomes Measurement Information System (PROMIS) physical function form (PF-10a) in routine practice in a racially and ethnically diverse population with rheumatoid arthritis (RA). Objectives were to determine feasibility of implementing PF-10a in the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22956
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti-NXP-2) antibodies. METHODS:We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employin...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23210
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:Symptomatic knee osteoarthritis (OA) is a condition commonly associated with increased pain, disability, and functional limitations. Given the poor correspondence between radiographic evidence and clinical pain, central sensitization has been implicated as a potential mechanism underlying pain facilitation in...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22712
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To determine whether slower walking speed was associated with an increased risk of incident hip and knee osteoarthritis (OA)-related outcomes. METHODS:After providing informed consent, community-dwelling participants in the Johnston County Osteoarthritis Project completed 2 home-based interviews and an addit...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21655
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To examine the secular trend of hip fracture incidence in Belgium between 2000 and 2007 and the concomitant change in the prescriptions of antiosteoporosis medications. METHODS:The incidence of hip fractures and the number of prescriptions were determined using national databases. A logistic regression inclu...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21607
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:The Psoriatic Arthritis Disease Activity Score (PASDAS) is a composite measure of psoriatic arthritis (PsA) disease activity. The length of its patient-reported components raises concern about questionnaire burden. The PASDAS includes the Medical Outcomes Study Short Form 36 (SF-36) health survey. We undertoo...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23876
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. METHODS:Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20571
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash of DM without objective muscle weakness. Asian studies report that anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in CADM is associated with interstitial lung dis...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22728
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To develop and pilot test a screening tool to identify cases of nephrogenic systemic fibrosis (NSF) among patients exposed to gadolinium-containing contrast agents. METHODS:Sixty English-speaking subjects were enrolled: 10 subjects diagnosed as having NSF, 10 subjects with other fibrosing skin diseases, 20 s...
journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章
doi:10.1002/acr.21877
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:By 2030, the number of permanently homebound individuals in the US will increase by 50% to reach 2 million. However, no medicine subspecialty consult services exist for this rising subset of the population. This pilot program establishes a rheumatology consult service for the Mount Sinai Visiting Doctors, the...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20539
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To validate a magnetic resonance imaging (MRI) reference criterion for a positive sacroiliac (SI) joint MRI finding based on the level of confidence in the classification of spondyloarthritis (SpA) by expert MRI readers. METHODS:Four readers assessed SI joint MRIs in 2 inception cohorts (cohorts A and B) of ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21893
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. We investigated whether women's smoking was positively associated with SLE-associated pro-inflammatory chemokines/cytokines, [stem cell factor (SCF), B-lymphocyte stimul...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24370
更新日期:2020-07-03 00:00:00
abstract:OBJECTIVE:Two surveys were conducted with patients with rheumatologic diseases to evaluate perceptions of different routes of administration (intravenous [IV] or subcutaneous [SC]) for biologic therapy. METHODS:In Survey I, patient preferences toward biologic treatment were evaluated at a rheumatology practice in Buff...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23758
更新日期:2019-09-01 00:00:00
abstract::Objective: To test the hypothesis that cartilage displays significant longitudinal thickening in the external subregions of the central medial (ecMF) and lateral (ecLF) femur in knees with early radiographic osteoarthritis (ROA) compared with contralateral knees without ROA, and to explore differences in change in oth...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22172
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To examine the association between leisure time physical exercise, body mass index (BMI), and risk of fibromyalgia (FM). METHODS:A longitudinal study with baseline assessment of physical exercise (frequency, duration, and intensity) and BMI was used to explore the risk of having FM at 11-year followup in a l...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20118
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:There are few reports on the treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) in children. This study characterizes the use of cyclophosphamide, rituximab, and plasma exchange in children hospitalized with AAV in the US. METHODS:We conducted a retrospective cohort study of childre...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23142
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of magnetic resonance imaging (MRI) osteoarthritis (OA) features in the patellofemoral or tibiofemoral joint (i.e., bone marrow lesions, cartilage lesions, and osteophytes) and/or functional impairments, 1 year following anterior cruciate ligament reconstruction (ACLR), can p...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22761
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:We propose new classification criteria for Sjögren's syndrome (SS), which are needed considering the emergence of biologic agents as potential treatments and their associated comorbidity. These criteria target individuals with signs/symptoms suggestive of SS. METHODS:Criteria are based on expert opinion elic...
journal_title:Arthritis care & research
pub_type: 共识发展会议,杂志文章
doi:10.1002/acr.21591
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:This study was performed to determine the prevalence of elevated C-reactive protein (CRP) levels and the significance of CRP in clinical parameters in systemic sclerosis (SSc; scleroderma) patients. METHODS:Canadian Scleroderma Research Group data were used. Statistical comparisons were made for CRP levels ≤...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21716
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:Little is known about the natural history of knee osteoarthritis (OA). We sought to identify common patterns of joint space narrowing (JSN) in well-characterized knee OA patients in the placebo arm of a 2-year international study. METHODS:We performed secondary data analyses of 622 adults ages 39-80 years in...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.20614
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:This prospective study aimed to determine whether the comprehensive ultrasonographic assessment of synovial inflammation predicts relapse after discontinuation of treatment with a biologic agent in patients with rheumatoid arthritis (RA) in clinical remission. METHODS:RA patients in clinical remission (Disea...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22303
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To evaluate ixekizumab safety in adults with psoriatic arthritis (PsA). METHODS:Safety data from 2 integrated data sets are presented: 1) 24-week, double-blind, placebo-controlled period of SPIRIT-P1 and SPIRIT-P2; and 2) all ixekizumab-treated patients of SPIRIT-P1 and SPIRIT-P2 plus SPIRIT-P3 open-label pe...
journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.23738
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of a 12-session walking skill training program of weight-bearing activities on physical functioning and self-efficacy initiated in patients 3 months after total hip arthroplasty (THA). METHODS:Sixty-eight patients with THA, 35 women and 33 men, with a mean age of 66 years (95% confi...
journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.20681
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Cognitive function may change over time in patients with SLE, and cognitive function trajectories have not well been studied. We aim to: 1) identify cognitive function trajectories in SLE and describe it with depressive symptoms trajectories and 2) identify baseline factors associated with class membership i...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24349
更新日期:2020-06-11 00:00:00
abstract:OBJECTIVE:To investigate whether patients affected by 1 of the 3 subsets of early systemic sclerosis (SSc; scleroderma), i.e., subset I, Raynaud's phenomenon with SSc marker autoantibodies and typical capillaroscopic findings; subset II, autoantibody positive only; and subset III, capillaroscopy positive only and not s...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22304
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Illness behaviors (cognitive, affective, and behavioral reactions) among individuals with systemic sclerosis (SSc; scleroderma) are of clinical concern due to relationships between these behaviors and physical and mental quality of life, such as pain and symptoms of depression. Self-report measures with good ...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21874
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To investigate differences in EMG muscle activity and scapular kinematics during elevation in the scapular plane between healthy controls, participants with multidirectional shoulder laxity (MDL), and patients with multidirectional shoulder instability (MDI) who are diagnosed with hypermobile Ehlers-Danlos sy...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24525
更新日期:2020-11-30 00:00:00
abstract:OBJECTIVE:Hydroxychloroquine (HCQ) has been associated with improved survival among SLE patients from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. METHODS:We conducted a nested case-control study within an incide...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.24255
更新日期:2020-05-14 00:00:00
abstract:OBJECTIVE:We aimed to determine if there were sex differences in lean body mass (LBM) in patients with rheumatoid arthritis (RA) when compared with sex- and race-specific National Health and Nutrition Examination Survey (NHANES) reference data, and to investigate the impact of sex differences in risk factors for LBM de...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22396
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Localized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients. METHODS:We analyzed longitudinal data from a single-center cohort of juvenile localiz...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23101
更新日期:2017-07-01 00:00:00