Vascular inflammation and endothelial dysfunction in experimental hypertension.

Abstract:

:Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.

journal_name

Int J Hypertens

authors

Savoia C,Sada L,Zezza L,Pucci L,Lauri FM,Befani A,Alonzo A,Volpe M

doi

10.4061/2011/281240

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

281240

eissn

2090-0384

issn

2090-0392

journal_volume

2011

pub_type

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